Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"Gonadotropin Releasing Hormone"”.
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Gonadotropin releasing hormone in agnathans
… vertebrates. The regulatory hypothalamic neurohormone, gonadotropin-releasing hormone (GnRH), regulates reproduction in all vertebrates through the hypothalamic-pituitary-gonadal axis. Most vertebrates have at least two forms of GnRH in the brain. In hagfish the primary amino acid structure of …
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Gonadotropin releasing hormone receptor ligand interactions
The decapeptide, gonadotropin releasing hormone (GnRH), is the central regulator of reproductive function. It binds to receptors on the gonadotrope cells of the pituitary and stimulates release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Eleven different structural forms of …
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Ligand-receptor interactions of Gonadotropin-releasing hormone antagonists
The interactions of selected GnRH agonists and antagonists with the GnRH receptor were investigated using site directed mutagenesis and photoaffinity cross/inking of the receptor with a labelled GnRH analog. With the aim of identifying residues involved in ligand binding, the relative affinities of …
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A Lamprey Gonadotropin-releasing Hormone in the Bovine Brain
Mammalian gonadotropin release from the anterior pituitary is under control of the hypothalamic luteinizing hormone-releasing hormone (LHRH) and a putative analog, follicle stimulating hormone-releasing factor (FSHRF). Analogs of mammalian LHRH and their receptors have been isolated in various …
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Time of Day Influences on Gonadotropin Releasing Hormone Neurons
Gonadotropin Releasing Hormone (GnRH) neurons are typically referred to as the final component of the neuronal network that regulated reproduction. Though it has been known since the 1920's that the decapeptide released by these neuroendocrine cells is the fundamental driver of ovulation in …
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Self-assembly of a gonadotropin-releasing hormone antagonist-Teverelix
Peptide and protein aggregation (self-assembly) has been an important topic for many years, since it is implicated in a range of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and Huntington’s Diseases. At the same time, it also represents a significant challenge for the …
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Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)
This thesis explores the relation between gonadotropin-releasing hormone (GnRH) and gastrointestinal symptoms and dysmotility. In primary Sjögren’s syndrome (pSS), a patient group with high levels of GnRH antibodies, associations between objective signs and symptoms of autonomic dysfunction (AD), …
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IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling
Stimulation of gonadotropin-releasing hormone (GnRH) receptors on the surface of anterior pituitary gonadotrope cells is a key signaling event for the hypothalamic-pituitary-gonadal axis. One important downstream component of GnRH receptor signaling is activation of the mitogen-activated protein …
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The cloning of novel gonadotropin-releasing hormone receptors by polymerase chain reaction
Gonadotropin-releasing hormone (GnRH), a central regulator of reproductive function in all vertebrates, exerts its effects via binding to the GnRH receptor (GnRHR) in the pituitary gonadotrophs. The GnRHR is a member of the G-protein coupled receptor (GPCR) superfarnily. A second form of the GnRHR …
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Autocrine regulation of gonadotropin-releasing hormone in immortalized hypothalamic GT1-7 neurons
The existence of an ultrashort feedback mechanism regulating GnRH secretion has been supported from in vivo and in vitro studies. However, the complex synaptic connections of GnRH neurons with other neural elements made it difficult to determine whether the regulation was mediated by direct actions …
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Evolution of the structure and function of vertebrate brain gonadotropin-releasing hormone
In this study, the structure and function of gonadotropin-releasing hormone (GnRH) in different vertebrate species, in the classes Aves, Reptilia and Pisces was investigated. Acetic acid extracts were subjected to gel filtration chromatography and semipreparative high performance liquid …
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Internalisation of the type II gonadotropin-releasing hormone receptor of marmoset monkey
The mammalian type II GnRH receptor has a C-terminal tail unlike the mammalian type I GnRH receptor, which uniquely lacks the cytoptasmic C- terminal domain. lnternalisation of a mammalian type ll GnRH receptor has never been investigated, therefore this thesis studies the internalisation pathway …
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β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor
Over-expression of β-arrestin 1 in COS-l cells revealed that the mammalian type GnRH receptor can internalise in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH …
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On the neuroendocrine regulation of reproduction: Functional characterization and kinetic studies of the lamprey gonadotropin -releasing hormone receptor and cloning and analysis of the cDNA encoding lamprey gonadotropin-releasing hormone-III
… (HPG) axis is regulated by gonadotropin-releasing hormone (GnRH), a decapeptide that is produced and released from the hypothalamus. At the anterior pituitary, GnRH action is mediated through high affinity binding with the GnRH receptor, a rhodopsin-like seven transmembrane …
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Ovarian and Pituitary Responses of Seasonally and Postpartum Anestrous Ewes to Gonadotropin Releasing Hormone
… anestrous ewes were treated with saline or gonadotropin releasing hormone (GnRH) either intramuscularly in saline, subcutaneously in carboxymethylcellulose or subcutaneously in a gelatin capsule. Ewes were bled for progesterone determination prior to treatment and up to 13 days after …
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Gene structure, transcripts and transcriptional regulation of primate type II gonadotropin-releasing hormone receptors
Includes bibliographical references.
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The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation
The activation of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive cancer cell lines. The GnRHR couples to Gαq in pituitary gonadotropes. However, the GnRHR expressed in reproductive …
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The relationships between gonadotropin-releasing hormone, luteinizing hormone, and testosterone secretion in the male sheep
… conducted to elucidate the relationships between gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and testosterone (T) in the ram. In the first study, the relationships between GnRH, LH, and T secretion were examined in intact rams in May (during the non-breeding season), September …
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Generation of a FHV-1 Viral Vaccine Against Gonadotropin Releasing Hormone for Immunocontraception of Felines
… Enhanced Green Fluorescent Protein (EGFP), and Gonadotropin Releasing Hormone (GnRH). FliC has been shown to stimulate a heightened antibody response when antigens are expressed as fusion proteins with it. GnRH, a major reproductive hormone responsible for the development of testes and ovaries …
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Efficacy of Synthetic Gonadotropin Releasing Hormone Analogs for Control of Ovulation During Estrus Synchronization Protocols
Two experiments were conducted to determine efficacy of GnRH analogs, Cystorelin (CYS, gonadorelin diacetate tytrahydrate) and Factrel (FAC, gonadorelin hydrochloride), for use in beef timed AI synchronization. In Experiment one 342 beef cows from 7 herds were assigned CYS or FAC treatment as part …
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