Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 189 for “"Gonadotropin"”.
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Gonadotropin releasing hormone in agnathans
… The regulatory hypothalamic neurohormone, gonadotropin-releasing hormone (GnRH), regulates reproduction in all vertebrates through the hypothalamic-pituitary-gonadal axis. Most vertebrates have at least two forms of GnRH in the brain. In hagfish the primary amino acid structure of GnRH has …
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Gonadotropin releasing hormone receptor ligand interactions
The decapeptide, gonadotropin releasing hormone (GnRH), is the central regulator of reproductive function. It binds to receptors on the gonadotrope cells of the pituitary and stimulates release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Eleven different structural forms of …
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Ligand-receptor interactions of Gonadotropin-releasing hormone antagonists
The interactions of selected GnRH agonists and antagonists with the GnRH receptor were investigated using site directed mutagenesis and photoaffinity cross/inking of the receptor with a labelled GnRH analog. With the aim of identifying residues involved in ligand binding, the relative affinities of …
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A Lamprey Gonadotropin-releasing Hormone in the Bovine Brain
Mammalian gonadotropin release from the anterior pituitary is under control of the hypothalamic luteinizing hormone-releasing hormone (LHRH) and a putative analog, follicle stimulating hormone-releasing factor (FSHRF). Analogs of mammalian LHRH and their receptors have been isolated in various …
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The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… activation of the EGF receptor is important for gonadotropin-induced steroid production in the ovary. Trans-activation of the EGFR is mediated by an increase of cAMP and PKA signaling. However, steroidogenesis in the ovary is dependent on an extracellular ligandindependent mechanism, as MMPs were …
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Time of Day Influences on Gonadotropin Releasing Hormone Neurons
Gonadotropin Releasing Hormone (GnRH) neurons are typically referred to as the final component of the neuronal network that regulated reproduction. Though it has been known since the 1920's that the decapeptide released by these neuroendocrine cells is the fundamental driver of ovulation in …
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Self-assembly of a gonadotropin-releasing hormone antagonist-Teverelix
Peptide and protein aggregation (self-assembly) has been an important topic for many years, since it is implicated in a range of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and Huntington’s Diseases. At the same time, it also represents a significant challenge for the …
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Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)
This thesis explores the relation between gonadotropin-releasing hormone (GnRH) and gastrointestinal symptoms and dysmotility. In primary Sjögren’s syndrome (pSS), a patient group with high levels of GnRH antibodies, associations between objective signs and symptoms of autonomic dysfunction (AD), …
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IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling
Stimulation of gonadotropin-releasing hormone (GnRH) receptors on the surface of anterior pituitary gonadotrope cells is a key signaling event for the hypothalamic-pituitary-gonadal axis. One important downstream component of GnRH receptor signaling is activation of the mitogen-activated protein …
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Development of the induced gonadotropin surge mechanism in the prepubertal heifer
… and GnRH, respectively) to determine at what age gonadotropin surges could be induced. Two-, four-, six-, and eight-month-old heifer calves were challenged with GnRH or estradiol. Blood was sampled from the jugular vein every 15 minutes for 6 hours or hourly for 30 hours, for the two treatments, …
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EGFR Signaling Is Necessary for Gonadotropin-Induced Steroidogenesis and Oocyte Maturation
The mid-cycle luteinizing hormone (LH) surge triggers ovarian processes that are critical for normal female fertility, including steroidogenesis, oocyte maturation, and subsequent ovulation. Studies were designed to examine the LH-induced signaling pathways that regulate ovarian steroidogenesis, as …
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The cloning of novel gonadotropin-releasing hormone receptors by polymerase chain reaction
Gonadotropin-releasing hormone (GnRH), a central regulator of reproductive function in all vertebrates, exerts its effects via binding to the GnRH receptor (GnRHR) in the pituitary gonadotrophs. The GnRHR is a member of the G-protein coupled receptor (GPCR) superfarnily. A second form of the GnRHR …
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Autocrine regulation of gonadotropin-releasing hormone in immortalized hypothalamic GT1-7 neurons
The existence of an ultrashort feedback mechanism regulating GnRH secretion has been supported from in vivo and in vitro studies. However, the complex synaptic connections of GnRH neurons with other neural elements made it difficult to determine whether the regulation was mediated by direct actions …
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Evolution of the structure and function of vertebrate brain gonadotropin-releasing hormone
In this study, the structure and function of gonadotropin-releasing hormone (GnRH) in different vertebrate species, in the classes Aves, Reptilia and Pisces was investigated. Acetic acid extracts were subjected to gel filtration chromatography and semipreparative high performance liquid …
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GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells
Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on …
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Internalisation of the type II gonadotropin-releasing hormone receptor of marmoset monkey
The mammalian type II GnRH receptor has a C-terminal tail unlike the mammalian type I GnRH receptor, which uniquely lacks the cytoptasmic C- terminal domain. lnternalisation of a mammalian type ll GnRH receptor has never been investigated, therefore this thesis studies the internalisation pathway …
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Analysis and characterisation of human chorionic gonadotropin glycoforms in pregnancy and trophoblastic disorders
Human chorionic gonadotropin (hCG) is a heterogeneous glycoprotein hormone with a varying degree of carbohydrate moieties. Its glycosylation arrangements are increasingly recognized as a common and important element of disease pathophysiology and are associated with many disorders including …
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β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor
Over-expression of β-arrestin 1 in COS-l cells revealed that the mammalian type GnRH receptor can internalise in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH …
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On the neuroendocrine regulation of reproduction: Functional characterization and kinetic studies of the lamprey gonadotropin -releasing hormone receptor and cloning and analysis of the cDNA encoding lamprey gonadotropin-releasing hormone-III
… (HPG) axis is regulated by gonadotropin-releasing hormone (GnRH), a decapeptide that is produced and released from the hypothalamus. At the anterior pituitary, GnRH action is mediated through high affinity binding with the GnRH receptor, a rhodopsin-like seven transmembrane …
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Electrochemical immunosensor based on cyclodextrin supramolecular interactions for the detection of human chorionic gonadotropin
… strategies for the detection of human chorionic gonadotropin(hCG) is presented. This involves the modification of a gold surface with a thiolated β-cyclodextrin epichlorohydrin polymer (βCDPSH) to form a supramolecular inclusion complex with ferrocene (Fc)-functionalised carboxymethyl cellulose …
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