Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Golgi Morphology"”.
-
Investigation of conventional and unconventional protein secretion using galectin-3
… of the ER, proteins are trafficked through the Golgi and remain separate from the cytosol throughout their journey to the outside of the cell. More recently, proteins without a signal sequence have been found outside the cell. These proteins are secreted unconventionally, and avoid the ER-Golgi …
-
Novel Regulators of Cellular Secretion Alter The Tumor Microenvironment to Drive Metastasis
… and poor patient prognosis. (2) Altered Golgi morphology and enhanced Golgi exocytosis during EMT promotes lung cancer metastasis. Zeb1-mediated EMT regulates Golgi dynamics and integrity, thereby enhancing and polarizing Golgi exocytosis to the invasive front of the tumors to promote …
-
Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1
… is found in both endoplasmic reticulum (ER) and Golgi. Similar to yeast Sac1p, human SAC1 (hSAC1) is the major phosphatidylinositol-4-phosphatase (PI(4)P-phosphatase). Distinct localization of hSAC1 in both ER and Golgi membranes suggests that this PI(4)P-phosphatase has compartment specific …
-
The discovery of a role of FBXO7/PARK15 in intracellular trafficking
… Cells with reduced Fbxo7 displayed abnormal Golgi morphology and accumulation of secretion cargo in the Golgi. By complementing Fbxo7 KD cells with transgenic Fbxo7, I rescued the secretion defect and showed that this required the ubiquitin ligase activity of Fbxo7. In addition to Dynein …
-
Einfluss der endo-lysosomalen Qb-SNAREs Vti1a und Vti1b auf die subzelluläre Sortierung sowie auf signalgebende Prozesse im zentralen Nervensystem der Maus
… of the organelle structure revealed strong Golgi abnormalities in Vti1a-/- Vti1b-/- neurons. In vitro, the Golgi in hippocampal Vti1a-/- Vti1b-/- neurons showed a compact morphology and was mostly concentrated in the perinuclear region of the cell, whereas the Golgi of respective control …