Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Goblet cells"”.
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SNARE-mediated exocytosis of MUC2 from intestinal goblet cells
… threats from the single layer of epithelial cells. Replenishment and maintenance of the mucus layer is facilitated by goblet cells that produce and store MUC2 mucin within secretory granules. Release of mucin occurs constitutively to maintain the barrier and is inducibly when goblet cells …
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High MUC2 Biosynthesis and Production Augment Pro-Inflammatory Responses in Colonic Goblet Cells
Goblet cells are specialized secretory epithelial cells whose primary function is to secrete mucins into the lumen of the gastrointestinal tract to form the mucus layer, which acts as a physical barrier separating luminal contents from the underlying epithelium. During amoebiasis, caused by the …
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Pathogenic effects of Mycoplasma hyopneumoniae on porcine tracheal organ cultures and neutrophils in vitro, and porcine respiratory goblet cells in vivo
… airway mucin and the morphology of epithelial cells of pigs was studied. Bronchial goblet cell sulphomucin and sialomucin were quantitated by image analysis of lung sections stained with high iron diamine/Alcian blue. Goblet cells in bronchi of infected pigs contained significantly less total …
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A Cytological Study of the Secretory Activity of the Goblet Cells of the Intestine of the Golden Hamster, Cricetus Auratus, With Special Referenceto the Golgi Apparatus and Mitochondria
Made available in DSpace on 2014-12-04T22:45:52Z (GMT). No. of bitstreams: 1 0013456.pdf: 7043578 bytes, checksum: 596716faa76711f363b52d709259797d (MD5) Previous issue date: 1952
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Clinical and Molecular Analyses of Intestinal Goblet Cell Acidomucins and Cysteine Metabolism
Goblet cells are key contributors to intestinal mucosal barrier function through their role in production of mucins and other important secretory products, which include trefoil factor 3 (TFF3) and resistin like molecule β (RETNLB). Goblet cell mucins show great structural heterogeneity but can be …
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Dietary protein ameliorates goblet cell loss and modifies inflammatory responses in the colon of hnRNPI knockout mouse
… specifically knockout in intestinal epithelial cells (IECs) develop spontaneous colitis at an early age. Moderate dietary protein has been demonstrated to exert beneficial effects for individuals with colitis, however, mechanisms of how dietary protein impacts inflammation development and immune …
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Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… coupling mucus (MUC2) secretion in colonic goblet cells in situ, using an ex-vivo 3D model native human colonic crypt model system. Immunohistochemistry revealed the presence of cholinergic neurons in close proximity to the basal membrane of the crypts, where the muscarinic receptor (M3AchR) …
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The regulation of allergic airway disease by type V collagen-induced tolerance
… complement activation, were down regulated on goblet cells in murine allergic airway disease. Conclusions: Anti-col(V) immunity correlates with asthma pathogenesis, and col(V)-induced tolerance may be a novel therapeutic for asthma. Decreased expression of Crry/CD46 and CD55 on goblet cells may …
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Use of transgenic mice to study the role of autophagy protein ATG16L1 in Crohn’s Disease
… mice exhibited an enlargement of colonic goblet cells. In contrast, CD patients expressing *300A displayed smaller colonic goblet cells. Infected Atg16L1ΔIEC mice also exhibited colonic crypt atrophy and a reduced number of ileal villi; however there was no evidence of increased …
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Characterization of Ocular Surface Pathology and Tear Film Dysfunction Due to Type 1 and Type 2 Diabetes Mellitus
… and its various components like tear film, goblet cells and glycocalyx, has not yet been investigated. These pathological changes can potentially cause dry eye and corneal injury including epithelial erosion, impaired wound healing and keratopathy. As the mainstay treatment option for the …
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Childhood Asthma Deaths in North Carolina: 1999-2012
… l therapy. With exacerbations of asthma, the goblet cells of the airway mucosa also relea se mucous secretions into the airways, which can further obstruct the airway lumen. Severe exacerbations of asthma with significantly reduced airflow can potentially compr omise gas exchange in the …
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Pathogenesis of Dry Eye in Graft Versus Host Disease (GVHD): Role of Ocular Mucins and Conjunctival Fibrosis
… immunological attack by donor engrafted immune cells to host organs, including the eye surface. Mostly based on the time of disease onset after transplantation, GVHD is divided into the acute and chronic phase. The eyes may be involved in both acute and chronic GVHD, although ocular involvement …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
… IgE, airway hyperreactivity (AHR), inflammatory cells, and mucus-producing goblet cells. When rapamycin was administered after systemic sensitization, but just prior to allergen exposure to the lung, many key responses including increases in IgE, AHR, goblet cells, lung T cells, and IL-13 and …
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Mechanisms of virus infection of human airway epithelium cultured at an air-liquid interface (HAE-ALI)
… and gene delivery of airways. Primary epithelial cells isolated from tracheobronchial airways, grown in transwell at an air-liquid interface (ALI), undergo media-induced mucociliary differentiation. This process reproduces a bronchi tissue-like structure, resembling the morphology and physiology …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… fluid were evaluated.Human eosinophil EOL-1 cells were treated with LTE4 with or without pre-treatment of P113. Intracellular expression of ECP was evaluated by Western blot, secreted levels of ECP in cell culture supernatant were measured by ELISA. RESULTS: P113 treatment decreased AHR to …
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Delayed access to feed affects broiler small intestinal morphology and intestinal cell ontogeny
… to DAF. The Olfm4 mRNA can clearly identify stem cells in the intestinal crypt, which allows VH and CD to be measured, while Ki-67 marks the proliferating cells. The peptide transporter PepT1 is located on intestinal epithelial cells and plays a critical role in transporting di- and tripeptides. …
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A comparison of the pathological effects on the midgut of the European corn borer treated with Bacillus thuringiensis and Bacillus subtilis
… swelling and vacuolation of the epithelial cells, cellular disruption, and complete breakdown of the epithelial tissue and subsequent bacteremia. It was observed that the degree of pathology increased with an increase in the bacterial spore concentration.Electron microscopic examination of …
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Influence of infant milk formula processing on protein digestion and gut barrier health in vitro and in vivo
… < 0.05). MEM-IMF fed pigs had a higher number of goblet cells, acidic mucus and mucin-2 protein in the jejunum compared to pigs fed HT-IMF (P < 0.05). In the duodenum, MEM-IMF fed pigs had higher trypsin activity in the gut lumen, higher mRNA transcript levels of claudin-1 in the mucosal scrapings …
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Spatial-Temporal Regulation of the Atonal Homolog 1 Gene
… correct development of the cerebellar granule cells, the dorsal interneuron 1 population, gut goblet cells and the cochlear and vestibular hair cells of mice. The purpose of these studies was to determine how atonal homolog 1 is regulated by analyzing the activity of atonal homolog 1 regulatory …
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Local Inflammatory Responses in Pseudomyxoma Peritonei
… neoplastic disease arising from MUC2 producing goblet cells of the appendix and is characterized by the accumulation of massive amounts of mucinous ascites. Little is known about the tumor microenvironment that might give insight into the local inflammatory processes in the peritoneal cavity. …
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