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Showing 1 to 20 of 27 for “"GnRH receptor"”.

  1. Dissection of GnRH receptor-G protein coupling

    White, Colin D.The University of Edinburgh2009

    Hypothalamic gonadotropin-releasing hormone (GnRH) (GnRH I) is the central regulator of the mammalian reproductive system. Most vertebrates studied also possess a second form of GnRH, GnRH II. GnRH I acts on its cognate G proteincoupled receptor (GPCR) on pituitary gonadotropes and activates …

    edinburgh Repository record

  2. β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor

    Nkwayana, NonhlanhlaDepartment of Clinical Laboratory Sciences2006

    … in COS-l cells revealed that the mammalian type GnRH receptor can internalise in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH receptor are required for β~arrestin …

    cape-town Repository record

  3. The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation

    Phillips, Pumza SamanthaDivision of Medical Biochemistry2011

    The activation of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive cancer cell lines. The GnRHR couples to Gαq in pituitary gonadotropes. However, the GnRHR expressed in reproductive …

    cape-town Repository record

  4. The contribution of His7.36(305) of the GnRH receptor to ligand binding and receptor activation

    Mayevu, Ntateko Merriam ImmogenDivision of Medical Biochemistry2004

    … of individual amino acid residues of both the GnRH receptor and the GnRH ligand in receptor function. A His7.36(3o5) residue on transmembrane helix seven of the GnRH receptor was investigated for its contribution to the overall function of the receptor.

    cape-town Repository record

  5. The Mutation Analysis of GnRH1 and GnRH Receptor Gene in Korean Girls woth Central Precocious Puberty

    윤, 소영2011

    … 검사 5 3. 환자군과 대조군으로부터 채혈 5 4. Genomic DNA 추출 6 B. GnRH1 와 GnRH-R 유전자 돌연변이 분석 6 1. GnRH1 유전자의 돌연변이 분석 6 2. GnRH-R 유전자의 돌연변이 분석 7 C. GnRH1 와 GnRH-R 유전자의 단일염기다형성 유전자형 분석 7 1. GnRH1 유전자 돌연변이 분석을 통한 단일염기다형성 유전자형 분석 7 2. GnRH-R 유전자 돌연변이 분석을 통한 단일염기다형성 유전자형 분석 8 D. 통계분석 8 III. 결과 11 A. 진성 성조숙증 환자군과 정상대조군의 …

    ajou Repository record

  6. The role of steroidogenic factor-1 (SF-1) in gonadotropin-releasing hormone (GnRH) receptor gene regulation

    Pheiffer, Carmen PDivision of Chemical Pathology1998

    Gonadotropin releasing hormone (GnRH) is a key reproductive hormone in vertebrates and exerts its effects via the GnRH receptor (GnRHR) to result in the synthesis and release of the gonadotropin hormones in the pituitary gonadotrope cells. GnRHR expression is likely to be regulated in a tissue- and …

    cape-town Repository record

  7. An investigation of the role of N102 of the GnRH receptor in determining the potency of C-terminally modified agonist analogs

    Henshall-Howard, Marie-Paule Alix EmilieDivision of Chemical Pathology2000

    Three GnRH receptors with the mutations N102A, N102D and N102K, which were derived from the human GnRH receptor by site directed mutagenesis, were expressed in COS-1 cells. The effects of these mutations on the potency of seven C-terminally modified GnRH agonist analogs for the stimulation of IP …

    cape-town Repository record

  8. Internalisation of the type II gonadotropin-releasing hormone receptor of marmoset monkey

    Ronacher, KatharinaDivision of Medical Biochemistry2003

    The mammalian type II GnRH receptor has a C-terminal tail unlike the mammalian type I GnRH receptor, which uniquely lacks the cytoptasmic C- terminal domain. lnternalisation of a mammalian type ll GnRH receptor has never been investigated, therefore this thesis studies the internalisation pathway …

    cape-town Repository record

  9. Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor

    Coetsee, Marla CatherineDivision of Medical Biochemistry2008

    The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins. In contrast, GnRH receptors at extrapituitary sites induce anti-proliferative effects that do not correlate with Gq/11 activation. We propose that the two endogenous ligands, GnRH I …

    cape-town Repository record

  10. Cloning and characterisation of gonadotropin-releasing hormone (GnRH) receptors in the cichlid (Haplochromis burtoni) and the zebrafish (Danio rerio)

    Morley, Michelle GayeDepartment of Molecular and Cell Biology2003

    … forms of gonadotropin-releasing hormone (GnRH) in a single species is becoming a common occurrence. The highly conserved chicken GnRH II is present along with one or two other GnRHs, composing a combination unique to particular species. This multifunctional peptide is widely distributed …

    cape-town Repository record

  11. The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity

    Fromme, Bernhard JohannesDivision of Medical Biochemistry2001

    … neuropeptide, gonadotropin releasing hormone (GnRH) perferentially inteacts with GnRH type I receptors on the gonadotropes in the anterior pituitary. Activation of the GnRH receptor is required for the biosynthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH), …

    cape-town Repository record

  12. Cloning and characterisation of gonadotropin-releasing hormone receptors from species in non-mammalian vertebrate classes : amphibia and osteichthyes

    Troskie, Brigitte EliseDivision of Chemical Pathology1998

    … or more forms of gonadotropin-releasing hormone (GnRH) have been isolated from most vertebrate species. In most species, GnRH variants have been shown to occur in distinct areas of the peripheral and central nervous systems, the gonads and other peripheral organs. Although GnRH is a primary …

    cape-town Repository record

  13. A mutational analysis of the roles of cytoplasmic domains of the gonadotropin-releasing hormone receptor in coupling and internalization

    Pawson, Adam JamesDivision of Chemical Pathology1999

    The G protein-coupled receptor (GPCR) family is the largest group of homologous proteins in the human genome. GPCRs are of prime physiological and medical importance as the actions of a wide range of hormones and drugs are mediated by these receptors. The gonadotropin-releasing hormone (GnRH) …

    cape-town Repository record

  14. On the neuroendocrine regulation of reproduction: Functional characterization and kinetic studies of the lamprey gonadotropin -releasing hormone receptor and cloning and analysis of the cDNA encoding lamprey gonadotropin-releasing hormone-III

    Silver, Matthew Ren

    … is regulated by gonadotropin-releasing hormone (GnRH), a decapeptide that is produced and released from the hypothalamus. At the anterior pituitary, GnRH action is mediated through high affinity binding with the GnRH receptor, a rhodopsin-like seven transmembrane G-protein coupled receptor …

    unh-thes Repository record

  15. Ligand-receptor interactions of Gonadotropin-releasing hormone antagonists

    Assefa, DanielDepartment of Pathology1999

    The interactions of selected GnRH agonists and antagonists with the GnRH receptor were investigated using site directed mutagenesis and photoaffinity cross/inking of the receptor with a labelled GnRH analog. With the aim of identifying residues involved in ligand binding, the relative affinities of …

    cape-town Repository record

  16. The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes

    Wehmeyer, LanceDepartment of English Language and Literature2015

    Reciprocal modulation between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH …

    cape-town Repository record

  17. Gonadotropin releasing hormone receptor ligand interactions

    Flanagan, Colleen ADivision of Chemical Pathology1995

    The decapeptide, gonadotropin releasing hormone (GnRH), is the central regulator of reproductive function. It binds to receptors on the gonadotrope cells of the pituitary and stimulates release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Eleven different structural forms of …

    cape-town Repository record

  18. A Lamprey Gonadotropin-releasing Hormone in the Bovine Brain

    Warner, Kara E.Southwest Texas State University2001

    … (FSHRF). Analogs of mammalian LHRH and their receptors have been isolated in various animals; of these, the lamprey-gonadotropin-releasing hormone-IH (lampreyGnRH-IH) analog seems the most likely candidate as a possible independent FSHRF in the mammalian system. On the basis of these studies, …

    texas-state Repository record

  19. IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling

    Alqahtani, Huda A., author, Amberg, Gregory, advisor, Clay, Colin, committee member, Tamkun, Michael, committee member, DeLuca, Jennifer, committee memberColorado State University. Libraries2023

    Stimulation of gonadotropin-releasing hormone (GnRH) receptors on the surface of anterior pituitary gonadotrope cells is a key signaling event for the hypothalamic-pituitary-gonadal axis. One important downstream component of GnRH receptor signaling is activation of the mitogen-activated protein …

    colostate Repository record

  20. GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells

    Wormald, Patricia JDivision of Chemical Pathology1988

    Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on …

    cape-town Repository record

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