Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"GnRH antagonist"”.
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The Effects of a GnRH Antagonist, Cetrorelix, on Ovarian Function in Cattle
… were conducted to determine the effects of a GnRH antagonist, cetrorelix, on the follicular dynamics in cattle during different stages of follicular growth and in different endocrine milieus. The specific objective was to test the hypothesis that cetrorelix would induce regression of the …
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The control of prolactin secretion and the role of gonadotrophin releasing hormone in the production of concordant secretory spikes of luteinizing hormone and prolactin in the luteal phase of the menstrual cycle
… of the menstrual cycle have been proposed and GnRH has been implicated in the genesis of the concordance of these secretory spikes. Using a potent GnRH antagonist an experiment was undertaken to establish the role of GnRH by blocking this hypothalamic peptide and observing the effect that this …
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Ligand-receptor interactions of Gonadotropin-releasing hormone antagonists
The interactions of selected GnRH agonists and antagonists with the GnRH receptor were investigated using site directed mutagenesis and photoaffinity cross/inking of the receptor with a labelled GnRH analog. With the aim of identifying residues involved in ligand binding, the relative affinities of …
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SYNTHESIS OF PHARMACOLOGICALLY ACTIVE MOLECULES THROUGH BIOCATALYTIC APPROACHES: STUDY OF THEIR STEREOCHEMISTRY AND POLYMORPHISM BY MEANS OF SPECTROSCOPIC AND CRYSTALLOGRAPHIC METHODS.
… orally active gonadotropin-releasing hormone (GnRH) antagonist, approved for the treatment of sex hormone-dependent diseases, such as endometriosis and uterine fibroids. This PhD project was focused on this drug, studying its conformational features, and improving the synthetic procedures found …
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Autocrine regulation of gonadotropin-releasing hormone in immortalized hypothalamic GT1-7 neurons
… of an ultrashort feedback mechanism regulating GnRH secretion has been supported from in vivo and in vitro studies. However, the complex synaptic connections of GnRH neurons with other neural elements made it difficult to determine whether the regulation was mediated by direct actions on the …