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Showing 1 to 20 of 154 for “"GnRH"”.

  1. Receptor activation in GNRH receptors

    Ott, Thomas RuthardDivision of Chemical Pathology2000

    Includes bibliographical references.

    cape-town Repository record

  2. Dissection of GnRH receptor-G protein coupling

    White, Colin D.The University of Edinburgh2009

    Hypothalamic gonadotropin-releasing hormone (GnRH) (GnRH I) is the central regulator of the mammalian reproductive system. Most vertebrates studied also possess a second form of GnRH, GnRH II. GnRH I acts on its cognate G proteincoupled receptor (GPCR) on pituitary gonadotropes and activates …

    edinburgh Repository record

  3. Progesterone Regulation of the GnRH Pulse Generator

    Wall, EllenUniversity of Cambridge2024

    … represent the gonadotrophin- releasing hormone (GnRH) pulse generator responsible for driving the pulsatile release of GnRH and luteinising hormone (LH) secretion. In a healthy menstruating woman, following the mid-cycle ovulation, progesterone (P4) levels dramatically increase and exert a …

    cambridge Repository record

  4. Expression des Gonadotropin-Releasing-Hormon (GnRH)-Rezeptors in primären humanen Osteoblasten und Effekte des GnRH-Agonisten Triptorelin auf die Expression osteoblastärer Gene

    Klompen, Julia2012

    … die Brustdrüse. Darüber hinaus ist bekannt, dass GnRH eine Rolle bei der Brustkrebsmetastasierung in den Knochen spielt. Seine antiinvasive Wirkung bei der Kokultivierung von Brustkrebszellen mit primären humanen Osteoblasten (hOB) wurde bereits gezeigt. Daher stellte sich die Frage, ob GnRH …

    goettingen Repository record

  5. Structure-activity study of GnRH analogs having conformational constraints

    Tian, Zhenping1990

    This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

    iupui Repository record

  6. Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)

    Hammar, OskarInternal Medicine Research Unit2013

    … relation between gonadotropin-releasing hormone (GnRH) and gastrointestinal symptoms and dysmotility. In primary Sjögren’s syndrome (pSS), a patient group with high levels of GnRH antibodies, associations between objective signs and symptoms of autonomic dysfunction (AD), impaired gastric emptying …

    lund Repository record

  7. Mechanismen der Durchbrechung der sekundären Antiöstrogenresistenz durch GnRH-Analoga in Mammakarzinomzellen

    Block, Martin2012

    … Analoga von Gonadotropin-Releasing Hormon (GnRH)-I und -II stellen die Wirksamkeit von Tamoxifen in diesen Zellen wieder her. In der vorliegenden Arbeit sollten nun die mechanistischen Grundlagen der Antiöstrogenresistenz und ihrer Durchbrechung analysiert werden. Es wurde gezeigt, dass in …

    goettingen Repository record

  8. Design and characterisation of novel GnRH analogues conjugated to hapten carriers

    Ratcliffe, Karen E.The University of Edinburgh2003

    edinburgh Repository record

  9. The role of Ca²⁺ and cAMP in GnRH-stimulated LH release

    Wakefield, Ian KurtDivision of Chemical Pathology1991

    … this thesis a detailed study of the kinetics of GnRH-stimulated LH release was made. GnRH stimulated LH release in a biphasic manner. During the first 3 minutes of stimulation, there was a transient spike phase of release followed by plateau phase of lower amplitude. Both phases of release are …

    cape-town Repository record

  10. The Effects of a GnRH Antagonist, Cetrorelix, on Ovarian Function in Cattle

    Farmer, Dylan RUniversity of Saskatchewan2024

    … were conducted to determine the effects of a GnRH antagonist, cetrorelix, on the follicular dynamics in cattle during different stages of follicular growth and in different endocrine milieus. The specific objective was to test the hypothesis that cetrorelix would induce regression of the …

    sask Repository record

  11. Ovulatory response to GNRH agonist during early and late fall in mares

    Spencer, Kianna M.University of Illinois at Urbana-Champaign2022

    Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms

    uiuc Repository record

  12. GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells

    Wormald, Patricia JDivision of Chemical Pathology1988

    Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on …

    cape-town Repository record

  13. β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor

    Nkwayana, NonhlanhlaDepartment of Clinical Laboratory Sciences2006

    … in COS-l cells revealed that the mammalian type GnRH receptor can internalise in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH receptor are required for β~arrestin …

    cape-town Repository record

  14. Einfluss von GnRH Analoga auf die Metastasierung humaner Mammakarzinomzellen in vitro und in vivo

    Schubert, Antje2012

    … % der humanen Mammakarzinome eine Expression von GnRH Analoga aufweisen, ist eine direkte Rezeptor-vermittelte Therapie mit GnRH Analoga in diesen Karzinomzellen von großer Bedeutung. Es wurde gezeigt, dass GnRH Analoga in der Lage sind die Knochen-gerichtete Invasion von Mammakarzinomzellen in …

    goettingen Repository record

  15. Role of GnIH and GnRH in Paracrine Control of Gametogenesis in Zebrafish (Danio rerio)

    Pourmohammadi Fallah, HamidehScience2020

    … It is well established that hypothalamic GnRH (Gonadotropin-Releasing Hormone) and GnIH (Gonadotropin-Inhibitory Hormone) are key peptides involved in the neuroendocrine control of gonadal function. However, the role of GnRH and GnIH as paracrine regulators of testicular and ovarian …

    calgary Repository record

  16. NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS

    AMORUSO, FEDERICAUniversità degli Studi di Milano2025

    … the secretion of gonadotropin-releasing hormone (GnRH), a neuropeptide that stimulates the release of gonadotropins from the pituitary, driving gametogenesis and sex steroid production. GnRH-secreting neurons originate from the olfactory placode during embryogenesis and migrate into the forebrain …

    milano Repository record

  17. The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation

    Phillips, Pumza SamanthaDivision of Medical Biochemistry2011

    … of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive cancer cell lines. The GnRHR couples to Gαq in pituitary gonadotropes. However, the GnRHR expressed in reproductive cancer …

    cape-town Repository record

  18. The contribution of His7.36(305) of the GnRH receptor to ligand binding and receptor activation

    Mayevu, Ntateko Merriam ImmogenDivision of Medical Biochemistry2004

    … of individual amino acid residues of both the GnRH receptor and the GnRH ligand in receptor function. A His7.36(3o5) residue on transmembrane helix seven of the GnRH receptor was investigated for its contribution to the overall function of the receptor.

    cape-town Repository record

  19. The impact of GnRH-agonist triggers on autologous in vitro fertilization outcomes: A retrospective analysis

    Oosthuizen, LizleDepartment of Obstetrics and Gynaecology2020

    … maturation before ultrasound guided aspiration. GnRH-agonists have been utilized as an alternative to hCG for oocyte maturation prior to follicle aspiration. GnRH-agonist triggers are proven to lower ovarian hyperstimulation syndrome risk, a condition that can be life threatening. Lower pregnancy …

    cape-town Repository record

  20. GnRH- und Galanin-Expression in der menschlichen Plazenta im Verlauf der Schwangerschaft und nach Galanin-Stimulation

    Bracknies, Vera KerstinUniversität Ulm

    ulm-diss Repository record

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