Global ETD Search
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Showing 1 to 11 of 11 for “"Glyoxalase."”.
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Nucleotide Inhibition of Glyoxalase II
The glyoxalase system mediates the conversion of methylglyoxal, a toxic ketoaldehyde, to D-lactic acid. The system is composed of two enzymes, glyoxalase I (Glo-I) and glyoxalase II (Glo-II), and exhibits an absolute requirement for a catalytic quantity of glutathione (GSH). Glo-I catalyzes the …
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Population Frequencies of Carbonic Anhydrase (CA II), Esterase D (EsD), and Glyoxalase I (GLO) in the Metropolitan Birmingham Area.
The identification of individual source is one of the main objectives of the forensic serologist when analyzing blood, bloodstains, or other body fluids. Certainly, the more we know about a specific blood sample, the more we can learn about an alleged criminal act. All individuality is due to …
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Loss of function of Gene X protects against α-dicarbonyl stress through the skn-1 pathway in C. elegans
… and DNA and, are regulated by a conserved glyoxalase system (<em>GLO1</em> and <em>DJ-1</em>) in humans. Utilizing the conserved glyoxalase system, we were able to establish within a <em>C. elegans </em>model that when this glyoxalase system is impaired, the damages of α-dcs are reminiscent …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… α-dicarbonyls are detoxified by a set of glyoxalase enzymes, glyoxalase I (GLO1) and glyoxalase II (GLO II), that are responsible for catalyzing MGO into D-lactate preventing the formation of AGEs. Therefore, preventing the formation of excessive AGE buildup is essential for limiting the …
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Design and synthesis of potential inhibitors of enzymes involved in the biosynthesis and utilisation of mycothiol
… cloning and expression of active Mycobacterial glyoxalase I, in order to generate enzymes on which to assay the synthesised molecules, are also described. Linking of the quinone functionalities to the mycothiol-like scaffold, phenyl-1-thio-Dglucosamine, was envisaged to facilitate delivery of …
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The role of lactate in CD4+ T cell differentiation and function
… from methylglyoxal’s detoxification through the glyoxalase system. Although under homeostasis tissular lactate levels are low, during the course of inflammatory processes and cancer development concentrations of both lactates can considerably increase. While L-lactate has been already studied in …
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Structure-function studies of the Parkinsonism-linked protein DJ-1
… A107P mutation on DJ-1 structure and glyoxalase activity. The A107P variant abrogates the ability of DJ-1 to protect against glyoxal-induced cytotoxicity and carboxymethyllysine protein modification. A crystal structure of DJ-1 C106S variant with glycerol and sulphate bound in the …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
… <p>Finally, I explored the potential of imaging glyoxalase-1 (Glo-1) activity with [2-<sup>13</sup>C]Methylglyoxal for detecting metabolic heterogeneity between breast and ovarian cancer PDXs. However, Glo-1 activity did not differ between ovarian or breast cancer subtypes and therefore while …
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Role of Oxidative Stress in Behavioral, Cognitive and Biochemical Impairment in a Rat Model of Social Stress
… cellular pool of key antioxidant enzymes such as glyoxalase-1, glutathione reducatse-1 and superoxide dismutases in specific regions of the brain including the hippocampus and amygdala. Next, utilizing an in-vitro model of oxidative stress, we examined contribution of Quercetin (Q), Resveratrol …
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Metallo-β-lactamase-like enzymes from non-pathogenic organisms: an illustration of functional promiscuity
… with N-acyl homoserine lactonases (AHLases) and glyoxalase II (GLX-II). Steady-state kinetic assays using a series of lactone substrates confirm that MIM-1 and MIM-2 are indeed efficient lactonases, with catalytic efficiencies resembling those of well-known AHLases. Interestingly, unlike their …