Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Glyoxalase system"”.
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Loss of function of Gene X protects against α-dicarbonyl stress through the skn-1 pathway in C. elegans
… and DNA and, are regulated by a conserved glyoxalase system (<em>GLO1</em> and <em>DJ-1</em>) in humans. Utilizing the conserved glyoxalase system, we were able to establish within a <em>C. elegans </em>model that when this glyoxalase system is impaired, the damages of α-dcs are reminiscent …
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The role of lactate in CD4+ T cell differentiation and function
… from methylglyoxal’s detoxification through the glyoxalase system. Although under homeostasis tissular lactate levels are low, during the course of inflammatory processes and cancer development concentrations of both lactates can considerably increase. While L-lactate has been already studied in …
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Nucleotide Inhibition of Glyoxalase II
The glyoxalase system mediates the conversion of methylglyoxal, a toxic ketoaldehyde, to D-lactic acid. The system is composed of two enzymes, glyoxalase I (Glo-I) and glyoxalase II (Glo-II), and exhibits an absolute requirement for a catalytic quantity of glutathione (GSH). Glo-I catalyzes the …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… α-dicarbonyls are detoxified by a set of glyoxalase enzymes, glyoxalase I (GLO1) and glyoxalase II (GLO II), that are responsible for catalyzing MGO into D-lactate preventing the formation of AGEs. Therefore, preventing the formation of excessive AGE buildup is essential for limiting the …