Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Glymphatic"”.
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The Role of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy
<p>In healthy brain tissue, toxic amyloid-β (Aβ) proteins are transported by the pulsatile flow of cerebrospinal fluid (CSF) along perivascular drainage pathways. Ischemic stroke may disrupt this process, leading to a perivascular build-up of Aβ, termed cerebral amyloid angiopathy (CAA). I …
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Clearance systems at brain borders
… of Doctor of Philosophy in Neuroscience. The glymphatic movement of fluid through the brain powerfully clears metabolic waste. We observed multisensory 40 Hz stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of …
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Glymphatic flow diurnal variation in the brain inhibited by circadian rhythm disruption and recovered by arginine vasopressin administration
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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DTI-ALPS REFLECTS WHITE MATTER DIFFUSION ANISOTROPY AND MICROSTRUCTURAL HETEROGENEITY RATHER THAN GLYMPHATIC FLOW: INSIGHTS FROM MULTI-MODAL MRI
The glymphatic system plays a critical role in the clearance of metabolic waste and pathological proteins such as amyloid-β and tau from the brain, and its dysfunction has been increasingly implicated in the pathogenesis of neurodegenerative diseases, making its in vivo characterization a major …
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A holistic multi-scale mathematical model of the murine extracellular fluid systems and study of the brain interactive dynamics
… the intramural periarterial drainage system, glymphatic system and meningeal lymphatic system. Impairment of these systems can potentially contribute to the onset of neurological disorders. The goal of this thesis is to contribute to the understanding of brain fluid dynamics and to the role of …
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The Role of Interstitial Fluid Flow in the Progression of Glioblastoma and Alzheimer's Disease
… a variety of changes including a reduction in glymphatic waste clearance and increase in glial reactivity. Two neurological conditions that affect individuals over the age of 65 include glioblastoma (GBM) and Alzheimer's disease (AD). Interestingly, patients with GBM do not present with AD and …
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Advancements in MRI-based quantitative measurement of slow physiological flows: Applications in neurological and vascular disease
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01