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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Glycosaminoglycans (GAGs)"”.
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Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells
… isolated from shellfish. However the effect of GAGs on normal lymphocyte populations is still unknown, identifying this action is essential in order to evaluate any potential use of GAGs as a cancer chemotherapy treatment in children. Aim: In order to further understand the potential use of GAGs …
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CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF CHONDROITIN SULFATE DISACCHARIDES
Glycosaminoglycans (GAGs) are heterogeneous polysaccharides comprising of repeating uronic acid and amino sugar disaccharide units. Recently, it was shown that the sulfate groups present in chondroitin sulfate GAGs (CS) encode important functional information for the regulation of physiological …
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GLYCOSAMINOGLYCAN COATED GOLD NANOPARTICLES FOR TARGETED BREAST CANCER THERAPY
… types of cancer cells, including breast cancer. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA) and chondroitin sulfate A (CSA), are known as binding ligands of CD44 receptor and were used as non-toxic targeting ligands in targeted cancer therapy. Gold nanoparticles have been demonstrated …
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Decellularized cartilage as a chondroinductive material for cartilage tissue engineering
… the extracellular matrix (ECM) such as collagen, glycosaminoglycans (GAGs), and ECM-based matrices have emerged as an essential subset of biomaterials for tissue engineering scaffolds. The objective of this research was to develop and evaluate decellularized cartilage (DCC) as a chondroinductive …
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Glycosaminoglycan regulation of cell function
Glycosaminoglycans (GAGs) are complex polysaccharides that exist both on the cell surface and free within the extracellular matrix. The intrinsic sequence variety stemming from the large number of building blocks that compose this biopolymer leads to substantial information density as well as to …
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Characterization Of The Skeletal Phenotype In Idua-W392X Knock-In Mice: Bone Metabolism Biomarkers
… IDUA catalyzes the degradation of the two glycosaminoglycans (GAGs); heparin sulfate (HS) and demantan sulfate (DS). The accumulation of HS and DS makes MPS I progressive with inevitable degeneration of multiple organ systems. Accumulated excess of GAGs on the skeletal system causes …
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Structural and Metabolic Studies of Glycosaminoglycans (Sulfatase, Hydrazine, Mucopolysaccharidosis)
A method for chemical cleavage of glycosaminoglycans (GAGs) at N-acetylhexosamine residues was developed. The reaction scheme involved N-deacetylation of the N-acetylhexosamine residues with hydrazine (N(,2)H(,4)) followed by nitrous acid (HONO) cleavage of the polymer at pH 4.0. Initial studies …
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Bioinformatics and database tools for glycans
… active role in modulating cellular activities. Glycosaminoglycans (GAGs) are one such family of polysaccharides that play a very important role in regulating the functions of numerous important signaling molecules and enzymes in the cell. Developing bioinformatics tools has been integral to …
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Enzymatic and analytical tools for the characterization of chondroitin sulfate and dermatan sulfate glycosaminoglycans
Glycosaminoglycans (GAGs) are complex polysaccharides that reside in the extracellular matrix and on the surfaces of all cells. The same complexity that contributes to the diversity of GAG function has also hindered their chemical characterization. Recent progress in coupling bacterial …
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Host response in sepsis
… studies have shown that increased levels of glycosaminoglycans (GAGs) inhibit the action of AMPs in chronic wounds. We found increased plasma levels of GAGs in sepsis patients correlating to mortality and level of circulatory derangement. GAGs at concentrations relevant to sepsis patients …
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Glycomics : an emerging paradigm to protein-carbohydrate interactions
Glycosaminoglycans (GAGs) are a family of complex carbohydrates whose known biological roles have dramatically increased over the recent years. It is now becoming increasingly evident that sequence specific GAG-protein interactions play critical roles in cell growth, development, angiogenesis, …
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MODELING OF THE CHEMOMECHANICAL INTERACTIONS BETWEEN CELLS AND THE EXTRACELLULAR MATRIX
… interactions. First, we examine the role of glycosaminoglycans (GAGs) within ECM. We show that due to their hydrophilic properties and contribution to the ECM’s mechanical integrity, GAGs can modulate the anisotropic strain-stiffening behavior of the ECM and further impact cellular force …
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Investigating the anti-proliferativeproperties and their mechanism(s) of actionof marine derived glycosaminoglycans fromtwo marine sources
… chemotherapeutic properties of marine derived glycosaminoglycans (GAGs) and investigate their mechanism(s) of action. The secondary purpose was to investigate differences between the already studied cockle derived GAGs and prawn derived GAGs. Nuclear magnetic resonance (NMR) spectroscopy was …
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Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development
… environment. Complex polysaccharides called glycosaminoglycans (GAGs) are part of this environment and they are known to modulate tumor development. One of these GAGs, dermatan/chondroitin sulfate (CS/DS), is attached to proteins either bound to the cell surface or secreted in the …
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Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification
… and were found to deplete the tumor of sulfated glycosaminoglycans (GAGs). This, in turn, increased the hydraulic conductivity of these tumors, enhancing the distribution and efficacy of infused oncolytic HSV. Genetic mutations were employed to enhance the activity of these enzymes, but impaired …
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Development of a Cellular Model for Morquio A Syndrome
… (GALNS), resulting in the accumulation of glycosaminoglycans (GAGs) such as keratan sulfate (KS) (Northover et al., 1996) and chondroitin-6-sulfate. There is no applicable animal model or appropriate cell lines currently available for the study of MPS IVA. Furthermore, patient-specific …
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Analysis of the Proteoglycan Content in Fresh and Cryopreserved Porcine Cardiovascular Tissues
… tissues with collagenase, elastase, and papain. Glycosaminoglycans (GAGs) of the PGs were isolated and quantitated. Gdn-HCl extracted about 61% and 62% of the total GAG (proteoglycan) material from cryopreserved and fresh tissues, respectively. Collagenase solubilized proteoglycans from …
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Human studies evaluating dGEMRIC as a prognostic tool for knee osteoarthritis
… disease, the articular cartilage is depleted of glycosaminoglycans (GAGs), which are responsible for cartilage load distribution and compressive stiffness. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage, abbreviated dGEMRIC, can be used to estimate the GAG content of …
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Examination of Microsporidia Spore Adherence and Host Cell Infection <em>In Vitro</em>.
… <em>Encephalitozoon intestinalis</em> binds glycosaminoglycans (GAGs) associated with the host cell surface, and that the divalent cations manganese (Mn<sup>2+</sup>) and magnesium (Mg<sup>2+</sup>) augment spore adherence to host cells by activating a constituent on the spore surface. These …
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An investigation into the effects of inorganic element status on the accumulation and deposition of amyloid in various diseases.
… such as serum amyloid P component (SAP), glycosaminoglycans (GAGs) may be involved, and metals such as aluminium, copper, zinc and calcium have also been implicated. Metals have been shown to induce aggregations of amyloid and accelerate amyloid deposition. The present study involved the …
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