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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 111 for “"Glycosaminoglycans"”.
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Measurement of urinary glycosaminoglycans in dogs
… increased urine concentrations of sulfated glycosaminoglycans (GAGs). Differences exist between normal patients, those with glomerulonephritis (GN), and those with amyloidosis thus potentially allowing differentiation without a renal biopsy. Aims of this study were to validate a simple …
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Circulating proteoglycans and glycosaminoglycans during critical illness
… are the proteoglycans with their attached glycosaminoglycans. At this location these molecules contribute to the adhesion and transport of leucocytes to inflamed tissue, the anticoagulation as well as the transport of fluid across the vessel wall. All these functions are disturbed during …
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Toward the automated synthesis of carbohydrates and glycosaminoglycans
Glycosaminoglycans are crucial components of the extracellular matrix and cell surface and access to define sequences is required to fully appreciate their role in biology. As is the case with most complex polysaccharides, the chemical synthesis of glycosaminoglycan structures is challenging. This …
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Glycosaminoglycans and proteoglycans in the developing rat brain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Nano-Mechanics of Cartilage Glycosaminoglycans Using Molecular Dynamics Methods
… of AC. This work focuses on the study of glycosaminoglycans (GAGs), a molecule known to be primarily responsible for the compressive stiffness of AC, using molecular dynamics methods. First, a single chain simulation is run to establish a chain length to use for the rest of the study. Then …
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Structural and Metabolic Studies of Glycosaminoglycans (Sulfatase, Hydrazine, Mucopolysaccharidosis)
A method for chemical cleavage of glycosaminoglycans (GAGs) at N-acetylhexosamine residues was developed. The reaction scheme involved N-deacetylation of the N-acetylhexosamine residues with hydrazine (N(,2)H(,4)) followed by nitrous acid (HONO) cleavage of the polymer at pH 4.0. Initial studies …
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Novel tools for sequence and epitope analysis of glycosaminoglycans
… heparinum that degrade heparan/heparan sulfate glycosaminoglycans (HSGAGs) were cloned and characterized. These exolytic enzymes enabled the exo-sequencing of a HSGAG oligosaccharide. Phenylboronic acids (PBAs) were specifically reacted with unsulfated chondroitin sulfate (CS) disaccharides from …
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Investigations into therapeutic discovery and delivery of heparin-like glycosaminoglycans
Heparin-like glycosaminoglycans (HLGAGs) are complex polysaccharides found both in extracellular matrix (ECM) and at the cell surface where they, in a sequence-specific manner, bind to and regulate the biological activity of numerous proteins. Due to a lack of effective tools to study …
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The Characterization of Glycosaminoglycans and Metallic Dianions in the Gas Phase
… disaccharide molecules of the Heparin family of Glycosaminoglycans (GAGs) have been studied in the gas phase to investigate their geometric structures and intrinsic stabilities. Low energy Collision Induced Dissociation (CID) in a quadrupole ion trap was used to investigate the relative …
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Towards embryonic scaffolds for regenerative medicine. Glycosaminoglycans, effector molecules and collagen
Contains fulltext : 182800.pdf (Publisher’s version ) (Open Access)
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The role of glycosaminoglycans in vascular stiffness and non-osmotic sodium storage
… was to investigate the interplay between sodium, glycosaminoglycans, vascular stiffness, and hypertension. In contrast to the traditional view of salt-dependent hypertension, recent studies have found that sodium accumulation can occur without commensurate fluid retention. Researchers hypothesise …
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Measuring the electrostatic repulsion forces between glycosaminoglycans using the atomic force microscope
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1999.
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Molecular interactions of glycosaminoglycans with fibroblast growth factor and with heparinase I
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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Analysis of the Structural Units of Sulfated Glycosaminoglycans by High Performance Ion Exchange Chromatography
The structural units of heparin produced by nitrous acid deamination were stoichiometrically reduced with NaB('3)H(,4) and analyzed by high performance ion exchange chromatography to obtain resolution of the four primary disaccharide units of heparin; 4-O-((beta)-D-glucopyranosyluronic …
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Enzymatic and analytical tools for the characterization of chondroitin sulfate and dermatan sulfate glycosaminoglycans
Glycosaminoglycans (GAGs) are complex polysaccharides that reside in the extracellular matrix and on the surfaces of all cells. The same complexity that contributes to the diversity of GAG function has also hindered their chemical characterization. Recent progress in coupling bacterial …
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Mechanical properties of selectively degraded cartilage explaints : correlation to the spatiotemporal distribution of glycosaminoglycans
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1996.
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Investigating the anti-proliferativeproperties and their mechanism(s) of actionof marine derived glycosaminoglycans fromtwo marine sources
… chemotherapeutic properties of marine derived glycosaminoglycans (GAGs) and investigate their mechanism(s) of action. The secondary purpose was to investigate differences between the already studied cockle derived GAGs and prawn derived GAGs. Nuclear magnetic resonance (NMR) spectroscopy was …
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Cartilage mechanobiology : the effects of loading on the fine structure and function of chondroitin sulfate glycosaminoglycans
Chondroitin sulfate is a critical component of articular cartilage due to its contribution to the tissue's resistance to compressive deformation. Alterations in the biosynthesis of this molecule over time could impact the ability of the tissue to perform its necessary functions. Several factors …
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