Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Glycoprotein VI"”.
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Platelet Receptor Glycoprotein VI in Ischaemic Stroke
… it is established that platelet surface receptor glycoprotein (GP) VI-dimer binds to exposed sub-endothelial collagen, initiating the signalling required to cause platelet activation. Then, separate platelet-fibrin interactions cause the thrombus to grow, culminating in distal tissue ischaemia; …
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Cellular regulation of platelet glycoprotein VI : in vivo and in vitro studies in mice
… with collagen, either indirectly through glycoprotein (GP) Ib-V-IX receptor complex, or directly through the major collagen receptor on the platelet surface, GPVI. The work presented here focused on studying the cellular regulation of GPVI. In addition, a possible role for GPVI in thrombus …
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In vitro and in vivo studies on the activating platelet collagen receptor glycoprotein VI in mice
… of the murine platelet collagen receptor glycoprotein (GP) VI and was performed to evaluate its potential as an antithrombotic target. The first mAb against (mouse) GPVI, JAQ1, was generated and used to demonstrate that GPVI requires the FcRgamma-chain for its expression and function and …
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Rheumatoid arthritis and atherosclerosis: common pathogenic mechanisms explored
… co-localise with CX3CR1 in human RA synovium, providing further evidence of the chemotactic effects between monocytes and the FKN/CX3CR1 axis and the significance of CX3CR1 in RA pathogenesis. Finally, I describe an association between seropositive RA and soluble Glycoprotein VI (sGPVI), …
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NOVEL REGULATORS OF GPVI-MEDIATED PLATELET ACTIVATION
… interaction with sub-endothelial collagen is Glycoprotein VI (GPVI). The activation of platelets leads to platelet shape change, granular secretion, thromboxane A2 (TXA2) synthesis, and integrin IIb3-mediated platelet aggregation and thrombus formation. In the past, a lot of effort has been …
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Regulation of Syk activity in GPVI-mediated platelet activation
… a signaling cascade is initiated, mediated by Glycoprotein VI (GPVI), which results in platelet activation. A major signaling protein in GPVI signaling is Spleen tyrosine kinase (Syk). It undergoes phosphorylation and activation following GPVI stimulation. Syk's central role in this …
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Molecular Mechanisms Underlying Differential Regulation of Platelet Dense Granule Secretion by Protein Kinase C delta
… of protease-activated receptors (PAR)s and glycoprotein VI (GPVI) receptors. We evaluated the role of PKCδ in platelets using two approaches - pharmacological and molecular genetic approach. In human platelets pretreated with isoform selective antagonistic RACK peptide (δV1-1)TAT, and in the …
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Adiponectin : a novel circulating anti-thrombotic factor in humans?
… was characterised. While it had been previously noted that gAd stimulated platelet aggregation through a tyrosine kinase-dependent mechanism, in this thesis we further elaborated the mechanisms underlying gAd-induced platelet aggregation by investigating the role of platelet secondary …
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The Regulation of Phosphorylation Events in Platelets
Platelets play a vital role in processes of hemostasis and thrombosis under physiological and pathological conditions. Following vascular damage, platelets will accumulate and stably adhere to exposed subendothelial matrixes. The binding of platelet surface receptor Glycoprotein VI (GPVI) to …