Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Glycopeptide antibiotics"”.
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Understanding the Genome-Wide Response of Streptomyces coelicolor to the Glycopeptide Antibiotic Teicoplanin
The glycopeptide antibiotics vancomycin and teicoplanin are clinically important as a second-line therapy to treat nosocomial infections caused by Gram-positive pathogens. Glycopeptide antibiotics universally target the terminal residues, D-Alanyl-D-Alanine on the cell wall peptidoglycan …
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(S) y (R) -N-BOC, O-Isopropiliden-Alfa-Metilserinales: utilización como precursores de productos de interés biológico
… 4-epi-L-vancosamina, carbohydrate of different glycopeptide antibiotics. Finally, we have attempted to extend this methodology to all sorts of compounds with a quaternary stereocentre that include an amine group. For this reason, we have developed a new synthetic strategy to achieve different …
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Organocatalytic synthesis of chiral non-racemic aziridines, labelled with 2H, 15N, 13C stable isotopes
… compounds such as vancomycin and teicoplanin glycopeptide antibiotics. Successful incorporation of 2H or 13C stable isotopes at α- or β-positions of enantiomerically enriched N-Cbz protected α-arylglycinols is reported with > 95% isotopic enrichment, yields of up to 73% and up to 98% e.e. …
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Detection of Vancomycin resistant Enterococci from clinical specimens at University Teaching Hospitals
… to Enterococcus species difficult. Resistance to glycopeptide antibiotics, especially Vancomycin is of special concern as Vancomycin resistant genes are encoded on plasmids which can be transferred to other organisms. Currently, there is no documented information relating to the occurrence and …
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Detection of Vancomycin resistant Enterococci from clinical specimens at University Teaching Hospitals
… to Enterococcus species difficult. Resistance to glycopeptide antibiotics, especially Vancomycin is of special concern as Vancomycin resistant genes are encoded on plasmids which can be transferred to other organisms. Currently, there is no documented information relating to the occurrence and …
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Remote asymmetric induction in the organocatalytic azaDarzens synthesis of peptide aziridines: towards the assembly of new glycopeptide antibiotic analogues
… development of bacterial resistance to antibiotics is an ongoing process which represents a growing problem for modern medicine. Vancomycin is used as a drug of last resort against methicillin-resistant Staphylococcus aureus (MRSA), but the increasing prevalence of vancomycin-resistant …
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Structural studies on the biosynthesis and biological functions of natural products
… by bacteria and plants. Teicoplanin is a glycopeptide antibiotic produced by Actinoplanes teichomyceticus and has been shown to be potent against many vancomycin-resistant strains. Such improved efficacy is mainly attributed to two special tailoring modifications that are unique for …
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Efforts Toward Production of Novel Natural Products From Uncultured Soil Microbes
… has led to the identification of many of the antibiotics currently in use today. Within the last 25 years, in fact, natural products (and their derivatives) account for almost three quarters of all antibiotic discoveries (Newman and Cragg). The discovery of novel natural product antibiotics, …
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Overexpression, purification and ligand interaction studies of intact membrane sensory kinases from enterococci: towards agonist and antagonist screening
… resistance to both vancomycin and teicoplanin antibiotics. VanSAsenses an unknown signalling ligand, which may either be the glycopeptide antibiotics them selves or more indirect ligands such as cell wall intermediates that accumulate in response to antibiotic inhibition of its cell wall target …