Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Glycopeptide"”.
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Structure and Function of Macromolecular Antifreezes (Peptide, Glycopeptide, Fish)
… fishes are protected from freezing by peptide or glycopeptide antifreezes which inhibit ice growth. The relationship between the structures of these molecules and the mechanism by which they work in investigated in this thesis.
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"Characterization of an antifreeze glycopeptide gene from the Antarctic cod, Notothenia neglecta, and a functional study of the ""pre-"" sequence of this antifreeze glycopeptide"
… a series of 8 different-sized antifreeze glycopeptides (AFGP 1 to 8) which lower the freezing point of its body fluids below that of sea water. I report here the sequence of one of its AFGP genes. The structural gene contains 46 tandemly repeated segments, each coding for one mature …
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Understanding the Genome-Wide Response of Streptomyces coelicolor to the Glycopeptide Antibiotic Teicoplanin
The glycopeptide antibiotics vancomycin and teicoplanin are clinically important as a second-line therapy to treat nosocomial infections caused by Gram-positive pathogens. Glycopeptide antibiotics universally target the terminal residues, D-Alanyl-D-Alanine on the cell wall peptidoglycan …
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Studies on the mechanism of action of the antimicrobial S-linked glycopeptide sublancin
Infectious diseases are a continuing threat to human health. In particular, the rapid development of bacterial antibiotic resistance not only decreases the effectiveness of known antibiotics, but also increases the need for the ongoing discovery of novel drugs. Since the discovery of penicillin, …
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NEW METHODS TO QUANTIFY METHIONINE OXIDATION AND PROTEIN GLYCOSYLATION AND A DE NOVO GLYCOPEPTIDE DECOY GENERATOR
Protein post-translational modifications (PTMs) produce complex, heterogeneous species that can best be identified and analyzed using mass spectrometry (MS). The ever-growing number of protein bioetherapeutics need effective MS tools to characterize PTMs and ensure drug safety and efficacy. …
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Vitamin A and glycoproteins of rat corneal epithelium
… of labeled precursors into a single specific glycopeptide in the rat intestinal mucosa was depressed significantly in vitamin A deficiency (De Luca et al ., 1970). A very similar pattern to the intestinal glycopeptide pattern was obtained from the rat corneal epithelium; namely, the …
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Remote asymmetric induction in the organocatalytic azaDarzens synthesis of peptide aziridines: towards the assembly of new glycopeptide antibiotic analogues
… of publications reporting the synthesis of glycopeptide analogues and derivatives in the last decade, highlighting the successful approaches which have brought new pharmaceutical drugs to the market. The results and discussion section of this work focusses first on the synthesis of a triaryl …
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Modulating activity of vancomycin and daptomycin on the expression of gene involved in reduced glycopeptide susceptibility in Staphylococcus aureus
Negli ultimi dieci anni l'aumentato uso di vancomicina e teicoplanina (glicopeptidi), come antibiotici di prima linea nel trattamento di infezioni causate da Staphylococcus aureus meticillino-resistenti (Methicillin Resistant S.aureus-MRSA), ha portato all'insorgenza di ceppi con ridotta …
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GLYCOPEPTIDE ANALYSIS OF HIV-1 ENVELOPE PROTEIN USING HPLC/ESI-FTICR MS AND MALDI-TOF MS WITH ASIALOFETUIN ENRICHMENT AND SEPARATION TECHNIQUES
… exhibits. Methodologies in characterization of glycopeptides often include a proteolytic digest followed by purification of the digested protein with liquid chromatography. Mass spectrometers are sensitive to salts and buffer contents, thus a purification of the sample before analysis is vital …
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Organocatalytic synthesis of chiral non-racemic aziridines, labelled with 2H, 15N, 13C stable isotopes
… compounds such as vancomycin and teicoplanin glycopeptide antibiotics. Successful incorporation of 2H or 13C stable isotopes at α- or β-positions of enantiomerically enriched N-Cbz protected α-arylglycinols is reported with > 95% isotopic enrichment, yields of up to 73% and up to 98% e.e. …
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Beta-o-glicosilación de péptidos que incorporan aminoácidos no naturales
… acids and their corresponding model beta-O-glycopeptides, are reported. From this study, it can be concluded that the incorporation of non-natural amino acids allows us to modulate as desired the conformational space of the model glycopeptides. The different conformations exhibited by these …
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Efforts Toward Production of Novel Natural Products From Uncultured Soil Microbes
… relevant small molecule antibiotics (glycopeptides), but also to develop, in conjunction with new strategies, improvements on existing metagenomics approaches. My work towards the discovery of novel glycopeptide antibiotics has led to the identification of six novel glycopeptide …
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The Ontogeny of Vaccine-Induced HIV-1 Glycan-Reactive Antibodies
… macaques following immunization with a synthetic glycopeptide mimic of the epitope bound by antibodies that target the first and second variable loops plus glycan (V1V2-glycan bnAb epitope). This V1V2 glycopeptide induced robust plasma antibody binding responses to HIV Env that contained the same …
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New insights into molecular recognition of epitopes related to MUC1 human mucin by lectins
… is a convenient cancer biomarker. Mucin-like glycopeptides and glycoproteins, in particular MUC1, incorporate this structure in their sequence. While in normal cells this O-glycosylated protein carries complex oligosaccharides, in cancer cells, MUC1 expression is increased and its glycans are …
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(S) y (R) -N-BOC, O-Isopropiliden-Alfa-Metilserinales: utilización como precursores de productos de interés biológico
… 4-epi-L-vancosamina, carbohydrate of different glycopeptide antibiotics. Finally, we have attempted to extend this methodology to all sorts of compounds with a quaternary stereocentre that include an amine group. For this reason, we have developed a new synthetic strategy to achieve different …
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Detection of Vancomycin resistant Enterococci from clinical specimens at University Teaching Hospitals
… to Enterococcus species difficult. Resistance to glycopeptide antibiotics, especially Vancomycin is of special concern as Vancomycin resistant genes are encoded on plasmids which can be transferred to other organisms. Currently, there is no documented information relating to the occurrence and …
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Detection of Vancomycin resistant Enterococci from clinical specimens at University Teaching Hospitals
… to Enterococcus species difficult. Resistance to glycopeptide antibiotics, especially Vancomycin is of special concern as Vancomycin resistant genes are encoded on plasmids which can be transferred to other organisms. Currently, there is no documented information relating to the occurrence and …
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A Biochemical and Biophysical Comparison of Fetal and Adult Bovine Liver Plasma Membranes.
… qualitatively different in both polypeptide and glycopeptide composition and that unique qualitative differences in polypeptide and glycopeptide composition existed between the adult and fetal plasma membranes. The differences observed in the protein composition of the adult and fetal cells …
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Synthesis of mannosylated peptides as components for synthetic vaccines
… either manual or microwave assisted solid phase glycopeptide synthesis (SPGS) on pre-loaded WANG resin. The mannosylated peptides thus prepared can be tested for their ability to bind mannose receptors on human APCs in vitro. In order to prepare compounds that could be analysed in biological …
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