Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Glycomics"”.
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Glycomics : an emerging paradigm to protein-carbohydrate interactions
… many challenges in this emerging area of glycomics, by taking an integrated approach that couples biophysical and biochemical methods with a bioinformatics framework to represent and process sequence information content in GAGs. With this motivation the thesis is divided into 4 components …
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REGULATION OF GLYCOSYLATION IN MAMMALIAN CELL LINES: INSIGHTS FROM STRUCTURAL GLYCOMICS, ANALYSIS OF GLYCOSYLATION-RELATED GENES AND FUNCTIONAL RNAI SCREENS
This thesis represents a multifaceted approach to elucidate the regulation mechanism of glycosylation in mammalian cell lines. First, N-linked and O-linked glycan structures of five commonly used mammalian cell lines, namely CHO-K1, BHK-21, HEK293, COS-7 and 3T3, were characterized by a combination …
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Bioinformatics and database tools for glycans
… consortium, the Consortium for Functional Glycomics, is a larger database that also aims to store polysaccharide structure-function information of a broader collection of polysaccharides. The ideas and concepts implemented in developing GlycoBank were instrumental in developing databases …
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Interpretable Supervised Learning and Graph-Based Optimization for Glycan-Lectin Binding
… data from the Consortium of Functional Glycomics, we predict glycan-lectin binding affinity and lectin specificity using an interpretable graph-based supervised learning framework. For the first time, we uncovered both monomers and motifs more precise than the monomer unit critical for …
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Characterization of Glycans Derived from Biological Samples Using LC-MS/MS
… conditions when their expressions are altered, glycomics are becoming leading areas in the development of biomarkers. These biomarkers present unique opportunities to refine clinical diagnostics and achieve more precise disease phenotyping. Such enhanced diagnostics and characterization will …
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Differential Network Analysis based on Omic Data for Cancer Biomarker Discovery
… transcriptomics, proteomics, metabolomics, glycomics etc. Typically, differential expression analysis (e.g., student's t-test, ANOVA) is performed to identify biomolecules (e.g., genes, proteins, metabolites, glycans) with significant changes on individual level between biologically …
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Screening of multi-omics biomarkers for Type 2 Diabetes Mellitus among Chinese population
… design, Study I combined genomics and glycomics factors to investigate the candidate genes and the glycosylation patterns of IgG that lead to increased FPG level among Chinese populations. Study I identified 9 new SNPs located in 5 genetic loci (RPL7AP27, SNX30, SLC39A12, BACE2 and …
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Improving reproducibility and standards in quantitative N-Glycoproteomic data
More than half of all human proteins are glycosylated, making glycosylation one of the most abundant post-translational modifications in proteomics. N-Glycosylation is a prevalent and diverse type of glycosylation with key roles in regulating systems such as protein folding and host-pathogen …
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Analysis of N-Linked Oligosaccharides of Prostate-Specific Antigen and Prostatic Acid Phosphatase in Prostatic Fluids
<p>Presently, prostate cancer is the most common cancer afflicting men in the United States, with serum PSA being the "gold standard" protein biomarker used in the clinic for detecting and diagnosing prostate cancer. Nonetheless, serum PSA levels can also be elevated in non-cancerous conditions as …