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Showing 1 to 17 of 17 for “"Glycolytic Pathway"”.
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Unique glycolytic pathway enzymes as molecular targets for novel anti-cryptosporidial drugs
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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METABOLIC SHIFT AND NICHE DIFFERENTIATION DURING DENITRIFYING PHOSPHORUS REMOVAL IN A TROPICAL CLIMATE
… of partial TCA-glycolysis cycle or complete glycolytic pathway in Accumulibacter affects phosphorus removal efficiency. Accumulibacter has also been shown to utilize nitrate or nitrite as terminal electron acceptor under anoxic conditions. Differences in microbial community structure were …
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DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
… factors in their capability to promote the glycolytic pathway in ovarian cancer cells. We demonstrated that LPA stimulated aerobic glycolysis as well as cell proliferation in ovarian cancer cell lines. The two parallel responses were LPA dose dependent. To determine whether LPA is unique in …
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The effects of sodium cations on rabbit muscle enolase : evidence for the binding of 2PGA to apo-enolase with Na⁺
… (2PGA) to form phosphoenolpyruvate (PEP) in the glycolytic pathway. Studies in the inactivation of rabbit muscle enolase by NaClO$\sb4$ show that both Mg$\sp{2+}$ and 2PGA protect the enzyme from the inactivation. The protection provided by Mg$\sp{2+}$ and 2PGA is attributed to a series of …
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Dichloroacetate, a inhibitor of pyruvate dehydrogenase kinase-1, attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer cells
… dichloroacetate (DCA), an inhibitor of the glycolytic pathway. The expression profile of hypoxia-inducible factor-1α (HIF-1α) and pyruvate dehydrogenase kinase-1 (PDK-1) were analyzed in tissues from 10 patients with gastric cancer who had different responses to adjuvant 5-FU treatment. For …
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Regulation of cellular glucose metabolism by HIV-1 infection
… Primarily because deregulation of this metabolic pathway can lead to either apoptosis or extended life span of the cells involved. Viruses are parasitic in nature, they utilize the host cellular pathways to support their own progeny; hence it is expected that viruses would regulate the central …
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GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE: A NEW MOLECULAR TARGET IN CHEMOTHERAPY
… of tumor cell-specific biochemical and signaling pathways is a pre-requisite for development of new, prospective anticancer drugs. In this study, we concentrated on the energy metabolism which is remarkably different in tumor and healthy cells. Cancer cells generate ATP mainly through the …
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Concurrent Infection of TRYPANOSOMA MUSCULI Kendell, 1906, and SCHISTOSOMA MANSONI Sambon, 1907 in Mice
… tested in this study. Although ablastin inhibits glycolytic pathway enzymes in young trypanosomes, it does not seem to affect those of the blood fluke. Effects of schistosome membrane function must also be ruled out as no reduction in worm burden and no morphological abnormalities were observed. …
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Insights into the Development of Chemotherapeutics Targeting PFKFB Enzymes
… enzymes control the primary checkpoint in the glycolytic pathway and are implicated in a multitude of diseases: from cancer, to schizophrenia, to diabetes, and heart disease. The inducible isoform, PFKFB3, is known to be associated with the upregulation of glycolysis in many cancers. The first …
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Inactivity and overfeeding related changes in skeletal muscle composition and metabolism in captive felids - are they at risk of developing metabolic syndrome?
… (CS), 3-hydroxyacyl CoA dehydrogenase (3HAD) and glycolytic (phosphofructokinase (PFK) and lactate dehydrogenase (LDH) enzyme capacities. The type IIA fibres were the predominant fibre type in both the wild (48%) and captive (44%) lions. No significant differences were evident in the overall fibre …
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Bioenergetics and dynamics of ciliary responses and systems biology of phototaxis in Chlamydomonas reinhardtii
… the enolase enzyme, one of the ciliary glycolytic enzymes that produces ATP in the cilia. Under a high constant-intensity of red light, the BF fluctuation is less than 2%. In the dark, BF of cpc1-2 is about 30 Hz which is lower than 806 probably due to less ATP being available. However, …
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Normal Glycolytic Enzyme Activity Is Critical For Hypoxia Inducible Factor-1A Activity and Provides Novel Targets For Inhibiting Tumor Growth
<p>Normal Glycolytic Enzyme Activity is Critical for Hypoxia Inducible Factor-1α Activity and Provides Novel Targets for Inhibiting Tumor Growth</p> <p>By Geoffrey Grandjean</p> <p>Advisory Professor: Garth Powis, D. Phil</p> <p>Unique to proliferating cancer cells is the observation that their …
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Skeletal muscle composition in various breeds of domestic dogs: (A comparative study)
… type composition, fibre size, oxidative and glycolytic metabolic capacity (citrate synthase (CS), 3-hydroxyacetyl co A dehydrogenase (3-HAD), creatine kinase (CK) and lactate dehydrogenase (LDH) enzyme activities). There was no significant difference between the TB and VL in any of the …
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Investigation of the mechanism of action of pep carboxylase
… reaction was caused by key intermediates in the glycolytic pathway and the Krebs cycle. Although citrate and pyrophosphate inhibited the reaction, these inhibitions were readily reversed by additional Mg⁺⁺ in the reaction mixture. A low concentration of hydroxylamine caused no inhibition of the …
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Investigating HK2 as a potential therapeutic target in glioblastoma
… An approach is to target abnormal metabolic pathways that are universally dysregulated in glioblastoma. The identification of potential targets and the development of therapeutic agents is crucial for the advancement of treatment. Hexokinase 2 (HK2) has a prominent role in glycolysis, acting …
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The anti-diabetic mechanisms by isoflavone genistein
… to an alternation in glucose uptake or the glycolytic pathway. Further, genistein (1-10 μM) induced both INS1 and human islet β-cell proliferation following 24 h of incubation, with 5 μM genistein inducing a maximal 27% increase. The effect of genistein on β-cell proliferation was neither …
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The architectural complexity of the human PDC core assembly
… (PDC) is a key multi-enzyme assembly linking the glycolytic pathway to the TCA cycle via the specific conversion of pyruvate to acetyl CoA and, as such, is responsible for the maintenance of glucose homeostasis in humans. PDC comprises a central pentagonal dodecahedral core of 60 dihydrolipoamide …