Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Glycogen synthase kinase 3 (GSK3)"”.
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Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
<p>The phosphatidylinositol 3-kinase (PI3K) pathway, through its major effector node AKT, is critical for the promotion of cell growth, division, motility and apoptosis evasion. This signaling axis is therefore commonly targeted in the form of mutations and amplifications in a myriad of …
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Gsk3 Mediates Signaling Upstream of Akt
The phosphatidylinositide 3 kinase (PI3K)/Akt signaling network plays a pivotal role in multiple cellular functions. PI3K links the extracellular growth factor receptors to the serine-threonine kinase Akt which, through phosphorylation of numerous intracellular proteins, mediates increased cell …
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DEVELOPMENT AND APPLICATION OF CHEMOENZYMATIC TOOLS TO VISUALIZE MAMMALIAN PHOSPHOLIPASE D SIGNALING
… screen to identify regulators of protein kinase C (PKC)-dependent PLD signaling. Combining these two modern chemical tools has proven to be extremely powerful and allowed us to identify a new role for glycogen synthase kinase 3 (GSK3) in regulating the transcription of PKC and PLD. This …
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Cellular mechanisms of environmental enrichment: Novel discovery-based strategies for target identification for neuropsychiatric disorders
… we knocked down the downstream target of AKT, glycogen synthase kinase 3 (GSK3) beta, with a novel adeno-associated viral (AAV) vector in the nucleus accumbens shell (NAcSh) of rats and found increases in depression-like and cocaine taking behaviors. Additionally, GSK3 beta knockdown …
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Can low-dose lithium supplementation protect against sarcopenic obesity in ovariectomized mice?
… and weakness that is associated with age. Glycogen synthase kinase 3 (GSK3) is a well-known negative regulator of muscle mass, strength, and the oxidative fibre type, and has been associated with weight gain and obesity. Our lab has found that inhibiting GSK3 using low-dose lithium (Li) …
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Partial GSK3 knockdown improves muscle performance in mdx mice: investigating the cellular mechanisms
… has recently shown that knocking down the enzyme glycogen synthase kinase 3 (GSK3) improved muscle strength and fatigue resistance in a preclinical model for DMD, the mdx mouse. However, the exact cellular mechanisms leading to these benefits remain unknown and is the purpose of the present …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… circuit of competitive inhibition between glycogen synthase kinase 3 (GSK3) and Akt, which promote the activity of the transcription factors FoxO1 and CREB, respectively. Super-low-dose LPS mildly activated FoxO1 and pro-inflammatory gene transcription without inducing anti-inflammatory …
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Regulation of sterol regulatory element binding protein-1 in bovine mammary epithelial cells
… known SREBP1-target genes SREBP1, fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD) were first validated in a bovine mammary epithelial cell line (MacT) and in bovine mammary tissues. At least one or two SRE binding sites in 24 selected lipogenic genes were identified within 50,000 …
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Presynaptic signalling in Huntington’s disease
… BDNF signalling molecules dynamin1 (Dyn1) and glycogen synthase kinase 3 (GSK3) in HttQ140/+ hippocampal neurons compared to Htt+/+. Thus the increase in ADBE exhibited by HttQ140 neurons is not due to the dysregulation of phospho-Dyn1 or phospho-GSK3. Akt1, which is known to be dysregulated in …
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INTEGRATING CHEMICAL, BIOLOGICAL AND PHYLOGENETIC SPACES OF AFRICAN NATURAL PRODUCTS TO UNDERSTAND THEIR THERAPEUTIC ACTIVITY
… for the survival of the trypanosome e.g. glycogen synthase kinase 3 (GSK3) and rhodesain. We also identified the biological processes predicted to be perturbed by the compounds e.g. “glycolysis”, “cell cycle”, “regulation of symbiosis, encompassing mutualism through parasitism” and …
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PKB/Akt : a critical regulator of lymphocyte, development and function
Protein kinase B (PKB), a serine threonine kinase, is highly involved in the regulation of cellular proliferation and survival. To characterize PKB’s function in lymphocyte development and activation, transgenic (tg) mice that express a membrane targeted constitutively active form of PKBa (myr PKB) …
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Altered Expression of Metabolic Proteins Contributes to Neuropathological Disease
… affect several downstream molecules including glycogen synthase kinase 3 (GSK3), glucose transporters (GLUTs), and ATP dependent potassium (KATP) channels. We first examined GSK3 and pTau and found that both GSK3β and pTau were increased in aged 3xTg-AD mice. Next we looked at the translocation …