Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"Glycogen synthase"”.
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Structure and regulation of yeast glycogen synthase
Glycogen is a major energy reserve in most eukaryotes and its rate of synthesis is controlled by glycogen synthase. The activity of eukaryotic glycogen synthase is regulated by the allosteric activator glucose-6-phosphate, which can overcome the inhibitory effects of phosphorylation. The effects of …
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Cloning and characterization of glycogen synthase from Dictyostelium discoideum
In Dictyostelium, glycogen metabolism plays a major role in development. Undifferentiated cells contain stores of glycogen that are broken down and converted to structural components in differentiated cells. The enzyme that synthesizes this developmentally important pool of glycogen is glycogen …
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Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
… and amplifications in a myriad of malignancies. Glycogen synthase kinase 3 (GSK3) was first discovered as the kinase responsible for phosphorylating and inhibiting the activity of glycogen synthase, ultimately antagonizing the storage of glucose as glycogen. Its activity counteracts the effects …
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Rabbit muscle glycogen synthase: primary structure and regulation by synergistic phosphorylation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes
… thesis aims at evaluating the essentiality of Glycogen Synthase Kinase 3 (TbGSK3 short; Tb927.10.13780) and chemically validating it as a potential drug target in T. brucei. TbGSK3 recombinant protein was biochemically characterised and screened against a focussed kinase library using the …
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Discovery of Novel Glycogen Synthase Kinase-3beta Inhibitors: Molecular Modeling, Virtual Screening, and Biological Evaluation
Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine protein kinase which is engaged in a variety of signaling pathways, regulating a wide range of cellular processes. Due to its distinct regulation mechanism and unique substrate specificity in the molecular pathogenesis of …
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
Insulin reguliert über seine Bindung an den Insulin Rezeptor in a-Zellen des endokrinen Pankreas eine Signalkaskade, die in einer Hemmung der Glucagongen-Transkription resulitert. In der vorliegenden Promotionsarbeit wurde dieser bis jetzt nicht vollständig aufgeklärte Mechanismus in Hinblick auf …
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
… molecule screen targeting GSCs, we identified glycogen synthase kinase 3-beta (GSK3ß) inhibitors as likely candidates. We observed that pharmacological and genetic knockdown of GSK3 induced apoptosis and differentiation, preferentially in the CD133-expressing tumor-initiating fraction. In …
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Mechanisms by Which Exercise Training Attenuates Blood Pressure in Animals: Roles of Cytokines, Oxidative Stress, and Glycogen Synthase Kinase-3â
Hypertension is a chronic multifactorial condition with high morbidity and mortality rates, currently affecting about one billion people worldwide. Currently available anti-hypertensive medications are found to be effective in reducing blood pressure (BP), but still more than 50% of those diagnosed …
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Bioengineering of a TAT-conjugated Peptide to Modulate the Activity of Glycogen Synthase Kinase-3 in Adult and Embryonic Stem Cells
… development of TAT-eIF2B, a peptide-inhibitor of glycogen synthase kinase-3 (GSK-3). TAT-eIF2B was found to be specific for GSK-3 and had a significant positive effect on the formation of neurospheres in embryonic stem cell cultures and on the survival of myeloid progenitors in cytokine-starved …
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Neuroprotective effects of the dual glycogen synthase kinase-3b and phosphodiesterase 7 inhibitor VP3.15 and of an enriched environment in germinal matrix-intraventricular hemorrhage
… thiadiazole family, with a dual action as a glycogen synthase kinase-3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitor. It has demonstrated neuroprotective and antiinflammatory effects in other neurodegenerative disorders. Given its promising properties, VP3.15 may represent a potential …
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Effect of Metabolic Enzymes on Amylopectin Content and Infectivity of Cryptosporidium parvum
… substrates: glucose, glucose-1-phosphate, and glycogen synthase were investigated to determine if they can be used to increase amylopectin stores and thus increase infectivity to aid in detection/storage of oocysts. Oocysts of Cryptosporidium parvum were suspended in 1mg/ml glycolytic enzymes …
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A study of the regulation of glycogen metabolism in Dictyostelium discoideum
This work discusses the regulation of glycogen metabolism in Dictyostelium discoideum during its developmental cycle. Specifically, the possible cAMP dependent regulation of glycogen phosphorylase and glycogen synthase was examined. In other systems, cAMP can regulate at the level of the gene …
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Glucose dynamics in rat skeletal muscle : recovery from osmotic stress
… media and analyzed for metabolite content and glycogen synthase percent activation. To determine glucose uptake during iso-osmotic recovery, muscles (n=6 per group) were incubated for sixty minutes in either hypo-, iso-, or hyper-osmotic media immediately followed by five minutes of iso-osmotic …
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Molecular and Cellular Signaling Mechanisms Elucidating Aldose Reductase Mediated Ischemia-Reperfusion Injury in the Myocardium
… mediated I/R injury is linked to changes in glycogen synthase kinase 3β (GSK3β) phosphorylation, and whether an increased flux via AR and resultant I/R injury is mediated by changes in autophagy.
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Identification of Substrates and Pathways Regulated by PAS Kinase
… two enzymes in the pathway for the synthesis of glycogen: UDP-glucose pyrophosphorylase and glycogen synthase. Genetic and biochemical data provide evidence that both of these enzymes are inhibited by PASK-dependent phosphorylation. We next examined the role of PASK in mammalian cells. With the …
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The Impact of Candida albicans Glycogen on Fitness, Virulence and Host Response
… Although largely unexplored in C. albicans, the glycogen metabolism pathway is a vital carbon assimilation and utilization system shown to be metabolically important in the model yeast Saccharomyces cerevisiae. Aside from the soluble glycogen that potentially contributes to Candida metabolism, …
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