Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Glycogen Synthase Kinase-3"”.
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Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
<p>The phosphatidylinositol 3-kinase (PI3K) pathway, through its major effector node AKT, is critical for the promotion of cell growth, division, motility and apoptosis evasion. This signaling axis is therefore commonly targeted in the form of mutations and amplifications in a myriad of …
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Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes
… resistance is an increasing problem. Protein kinases are well validated drug targets for a variety of human diseases with many inhibitors under development or in the clinic. The T. brucei kinome has been annotated and there is evidence of essentiality of some of the members of this family. …
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
… 2040-2305 enthielt. Dies konnte durch in vitro Kinase assays gezeigt werden. Die Ergebnisse zeigen, das GSK3-b in die Regulation des Glucagongens involviert ist.
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Bioengineering of a TAT-conjugated Peptide to Modulate the Activity of Glycogen Synthase Kinase-3 in Adult and Embryonic Stem Cells
… development of TAT-eIF2B, a peptide-inhibitor of glycogen synthase kinase-3 (GSK-3). TAT-eIF2B was found to be specific for GSK-3 and had a significant positive effect on the formation of neurospheres in embryonic stem cell cultures and on the survival of myeloid progenitors in cytokine-starved …
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
… molecule screen targeting GSCs, we identified glycogen synthase kinase 3-beta (GSK3ß) inhibitors as likely candidates. We observed that pharmacological and genetic knockdown of GSK3 induced apoptosis and differentiation, preferentially in the CD133-expressing tumor-initiating fraction. In …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… regulation of EZH2 activity by tumor suppressor kinase is not well understood. Glycogen synthase kinase 3 beta (GSK3b), a multifunctional serine/threonine kinase, is involved in many cellular processes. GSK3b also participates in neoplastic transformation, tumor development and regulate cancer …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… factors (BDNF). Lithium is also an inhibitor of glycogen synthase kinase-3 beta (GSK-3-β). We analyzed biomarkers obtained from participants in a randomized placebo-controlled trial of lithium in ART-treated individuals with moderate or severe HAND. We assayed markers at baseline and 24 weeks …
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Gsk3 Mediates Signaling Upstream of Akt
The phosphatidylinositide 3 kinase (PI3K)/Akt signaling network plays a pivotal role in multiple cellular functions. PI3K links the extracellular growth factor receptors to the serine-threonine kinase Akt which, through phosphorylation of numerous intracellular proteins, mediates increased cell …
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Targeting troubled translation : investigating novel therapeutic targets in mouse models of fragile X and 16p1 1.2 deletion syndrome
… of two novel targets, [beta]-arrestin2 and glycogen synthase kinase 3[alpha] (GSK3[alpha]) are able to independently modulate translation downstream of mGlu₅ Avoiding dose-limiting consequences and unwanted side effects of globally targeting mGlu₅ signaling, pharmacological inhibition of …
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DEVELOPMENT AND APPLICATION OF CHEMOENZYMATIC TOOLS TO VISUALIZE MAMMALIAN PHOSPHOLIPASE D SIGNALING
… screen to identify regulators of protein kinase C (PKC)-dependent PLD signaling. Combining these two modern chemical tools has proven to be extremely powerful and allowed us to identify a new role for glycogen synthase kinase 3 (GSK3) in regulating the transcription of PKC and PLD. This …
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Can low-dose lithium supplementation protect against sarcopenic obesity in ovariectomized mice?
… and weakness that is associated with age. Glycogen synthase kinase 3 (GSK3) is a well-known negative regulator of muscle mass, strength, and the oxidative fibre type, and has been associated with weight gain and obesity. Our lab has found that inhibiting GSK3 using low-dose lithium (Li) …
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De-Risking PET Radioligand Discovery for Neurodegenerative Diseases
… stimulating factor-1 receptor (CSF-1R); 2) glycogen synthase kinase-3 (GSK-3); and 3) transactivation response DNA-binding protein with molecular weight of 43 kDa (TDP-43). Utilizing autoradiography, a putative CSF-1R binding radioligand, [3H]CPPC, did not localize to microglia in the brain …
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Role of the PI-3K/Akt and ERK pathways in phencyclidine-induced neurotoxicity in neonatal rats and the protection by lithium and BDNF
… action of PCP on the phosphatidylinositol-3 kinase (PI-3K)/Akt and extracellular regulated kinase (ERK) pathways and suppressed activation of the pro-apoptotic factor, glycogen synthase kinase-3â (GSK-3â), evoked by PCP. Furthermore, blocking either the PI-3K/Akt or the ERK pathway …
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Cellular mechanisms of environmental enrichment: Novel discovery-based strategies for target identification for neuropsychiatric disorders
… we knocked down the downstream target of AKT, glycogen synthase kinase 3 (GSK3) beta, with a novel adeno-associated viral (AAV) vector in the nucleus accumbens shell (NAcSh) of rats and found increases in depression-like and cocaine taking behaviors. Additionally, GSK3 beta knockdown …
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Targeting protein kinases to manage or prevent Alzheimer’s disease
… One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta …
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Partial GSK3 knockdown improves muscle performance in mdx mice: investigating the cellular mechanisms
… has recently shown that knocking down the enzyme glycogen synthase kinase 3 (GSK3) improved muscle strength and fatigue resistance in a preclinical model for DMD, the mdx mouse. However, the exact cellular mechanisms leading to these benefits remain unknown and is the purpose of the present …
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Roles of GSK-3beta and PYK2 signaling pathways in synaptic plasticity
… examines the role of two signaling pathways, glycogen synthase kinase 3 beta (GSK- 3beta) and proline-rich tyrosine kinase 2 (PYK2), in LTD at rat hippocampal synapses. GSK-3beta, a serine/threonine kinase implicated in the pathophysiology of schizophrenia, mood disorders, and Alzheimer's …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… circuit of competitive inhibition between glycogen synthase kinase 3 (GSK3) and Akt, which promote the activity of the transcription factors FoxO1 and CREB, respectively. Super-low-dose LPS mildly activated FoxO1 and pro-inflammatory gene transcription without inducing anti-inflammatory …
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