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Showing 1 to 20 of 27 for “"Glyco"”.
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Discovery of Glyco-biomarkers for Diabetes and Complications in Diabetes
… hypothesis of this study was that the protein N-glycosylation pathway in diabetes might be influenced by elevated hexosamine flux in diabetes elevating sugar nucleotide levels. This, in turn, might affect the N-glycan branching pathway and result in detectable changes in plasma glycoprotein …
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Magnetic glyco-nanoparticles : a new tool to detect bacteria, cancer and atheroschlerosis
Thesis (Ph. D.)--Michigan State University. Dept. of Chemistry, 2010
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Development of Glyco-RNA Technologies & Elucidating the Roles of miRs in Head and Neck Cancer Metastasis
… project discusses the development of a novel glyco-RNA enrichment method that utilizes lectins. A method which is essential for the field of glyco-RNA research to progress faster. Currently there is only one way for glyco-RNA enrichment which both time and resource intensive. We developed a …
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A Study of the Structure of Bovine Casein Micelles and the Secondary Phase of Milk Coagulation Using Immobilized Enzymes
… micelles, and specifically the distribution of glyco- and carbohydrate-poor (kappa)-casein, has been studied by treating isolated casein micelles with soluble and immobilized proteases, (chymosin and pepsin) and soluble and immobilized (neuraminidase). Analysis of the reaction products gave us …
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Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers
… effective at detecting neutral sugars as well as glyco- and phospholipids. In solutions at physiologically relevant pH the fluorescent lanthanum complex binds neutral sugars with apparent binding constants comparable to those of arylboronic acids. Interference from commonly occurring anions is …
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Beiträge zur Glykobioinformatik Entwicklung von Software-Werkzeugen für die Glykobiologie
… Dabei entstanden die Programme findYSeries, Glyco-Fragment und peakAssign, die eine schnellere Auswertung von Massenspektren im Bereich der Glykobiologie gestatten. So kann mit diesen Programmen die glykosylierte Aminosäure, die Komposition, die Anzahl der Antennen eines Glykans oder sogar …
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Bounded Dynamic Source Routing in Mobile Ad Hoc Networks
A mobile ad hoc network (MANET) is a collection of mobile platforms or nodes that come together to form a network capable of communicating with each other, without the help of a central controller. To avail the maximum potential of a MANET, it is of great importance to devise a routing scheme, …
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Isolierung und Charakterisierung Neuromelanin-assoziierter Proteine aus Neuromelanin-Granula des menschlichen Gehirns mittels subzellulärer Proteomanalyse
… Proteasen, Proteinen des Metabolismus von (Glyco-)Lipiden und Glycoproteinen, aber auch Proteinen des Cytosols und des vesikulären Verkehrs. Entscheidend war die Anwesenheit von Proteinen des Endoplasmatischen Reticulums (ER); Calnexin gilt als ein melanogenes Chaperon, das nicht in …
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To the Frontier of RNA Glycosylation: Novel Insights from Metabolic Labelling
The recent discovery of glycosylated RNA (glycoRNA) has redefined our comprehension of the glyco-conjugate universe, uncovering an unprecedented link between glycans and RNA. The pioneering exploration of this novel biopolymer was driven by the metabolic carbohydrate reporter, per-O-acetylated …
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The Biophysical Role of the Cellular Glycocalyx: Engineering Glycoproteins to Control Cell-Surface Properties
The glycocalyx is the sugary coating on the surface of essentially all mammalian cells. Despite being a major class of biomolecules, research into carbohydrates has lagged behind other classes of biomolecules such as nucleic acids and proteins. The constituent parts of the glycocalyx are not …
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A Critical Evaluation of Screening versus Sample-by-Sample Analysis of Protein Aggregation using a Variety of Chromatographic and Spectroscopic Techniques
… out to assess the stability of this protein. Glyco-analysis was carried out to determine the glycan profile of the IgG1 protein and to ensure for consistency in product glycosylation. The stability of the glycoform was also examined in terms of length of storage under, different storage …
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Purification of glycoproteins from herpes simplex virus
The aim of this work was to purify type-specific glycoproteins from herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) for diagnostic use. The most likely candidate for a type-specific glycoprotein of HSV-1 is glycoprotein C (gC), although it has recently been shown to contain some type-common …
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Heparan sulfate glycosaminoglycan regulation of vasculogenesis
… in stem cell differentiation. Heparan sulfate glycosaminoglycans (HSGAG) are a crucial part of the dynamic extracellular matrix and have been shown to regulate multiple signaling cascades, including vasculogenic specific growth factors VEGF and FGF. The goal of this thesis is to elucidate the …
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Comparative study of rare- earth based ferrites for flammable and volatile organic compound gas sensors
… x ≤ 0.4) nanoparticles have been produced by the glyco-thermal technique and characterised by X-ray diffraction, electron microscopy, X-ray photoelectron spectroscopy, Mössbauer spectroscopy and gas sensing analyses. The X-ray diffraction results indicated that a pure cubic spinel phase was formed …
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STUDY OF COLLOIDAL INTERACTIONS MEDIATED BY BIOMOLECULAR RECOGNITION AND BY ELECTROKINETIC FLOWS.
… particular we have studied particles coated with glyco-lipids, so that the colloids are effectively coated with sugar groups. In agreement with previous literature we have found attractive interaction in carbohydrate-coated colloidal dispersions when calcium ions are present in the solution. The …
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Novel Poly(N-substituted glycine)s : synthesis, post-modification, and physical properties
… photo-initiators, and facilitated in the first glyco-peptoid prepared under environmentally benign conditions. Furthermore, poly(N-allyl glycine) demonstrated thermo-responsive behavior and could be prepared as a semi-crystalline bio-relevant polymer from solution (ie. annealing). Initial …
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Sequence-structure-function relationships of glycosyltransferases in families GT43, GT47, and GT64
… In eukaryotes, extracellular glycans and glyco-conjugates are synthesised or matured by glycosyltransferase enzymes in the Golgi apparatus. Most glycosyltransferases catalyse the formation of unique glycosidic bonds; thus, the activities of these enzymes are responsible for controlling the …
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The Role of the Stereociliary Glycocalyx in Hair Bundle Cohesion
… I demonstrated that the stereociliary glycocalyx acts as a negatively charged polymer brush, necessary for the soundness of the glyco-tethering hypothesis. I found by force-fiber photomicrometry that when the distal tips of stereocilia were brought together they formed elastic …
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Analysis and characterisation of human chorionic gonadotropin glycoforms in pregnancy and trophoblastic disorders
… chorionic gonadotropin (hCG) is a heterogeneous glycoprotein hormone with a varying degree of carbohydrate moieties. Its glycosylation arrangements are increasingly recognized as a common and important element of disease pathophysiology and are associated with many disorders including gestational …
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ENGINEERING WATER-SOLUBLE VARIANTS OF THE SINGLE-SUBUNIT OLIGOSACCHARYLTRANSFERASE
… in the asparagine-linked (N-linked) protein glycosylation pathway. OSTs exist in all domains of life and are capable of transferring a preassembled glycan from lipid carrier to an acceptor peptide. Bacterial OSTs are an single-subunit enzyme that are amenable to recombinant expression in …
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