Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)"”.
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The Study of Glyceraldehyde -3 -Phosphate Dehydrogenase (Gapdh) Function Targeted by Estrogen and Progesterone in the Central Nervous System: Physiological Implications
… model for the membrane action of estradiol on GAPDH in the hippocampus that reflects recent interesting reports from other laboratories as well as my own contributions to these novel functions of GAPDH.
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Molecular characterization and promoter analysis of the maize cytosolic glyceraldehyde 3-phosphate dehydrogenase gene family
… and protein synthesis. Maize cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been identified as one of the anaerobic polypeptides and mRNAs corresponding to a member of the gpc multi-gene family, gpc3, increase under anaerobiosis. This study extends further analysis of the …
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Physiological and Biochemical Response of Saccharomyces cerevisiae to Desiccation and Rehydration
… response. Molecular analysis focused on glyceraldehyde-3-phosphate dehydrogenase (GAPDH, E.C. 1.2.1.13), a multifunctional protein that is involved in several cellular processes other than glycolysis, including nuclear translocation under stress and intracellular sensing of oxidative …
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Functional analysis of the CP12 gene family in Arabidopsis
… two enzymes of the Calvin-Benson cycle, namely glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase (PRK). The regulation of these enzymes is achieved by the reversible formation of this multiprotein complex in response to a change in light intensity. In Arabidopsis, there …
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The synthesis and in vitro evaluation of siRNAs modified at the backbone with a novel triazole-based internucleotide linkage and abasic alkyl-chain linkages of varying length
… gene firefly luciferase and the endogenous gene glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in a dose-dependent manner. In addition, modifying the 3′- overhangs of siRNAs with the triazole backbone linkage, gave rise to increased nuclease resistance well beyond that of wild-type siRNA. …
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Genetic association between schizophrenia and type-2 diabetes
… (HKGs), beta-actin (ACTB) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) were used as the internal controls to normalize the Ct values of the target genes. Fisher’s combining probability test was used to determine the combined p values from the Student’s t-tests for two …
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Protein glycosylation by NleB and the secretion of therapeutic nanobody fusions
… fas-associated protein with death domain (FADD), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and tumor necrosis factor receptor type 1-associated death domain protein (TRADD), were then studied. Results detected that all three mammalian substrates were glycosylated by NleB on arginine …
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Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma
… and analysed using the comparative Ct method and glyceraldehyde 3-phosphate dehydrogenase (Gapdh) as the standard. Of the matched samples investigated, 75% showed increased expression of one or more of the DNA repair genes analysed, however, there was no clear pattern of expression and a wide …
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Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
… The mRNA level of the common house-keeping gene, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was found to be the same in control and sheared cells. The fact that GAPDH was unregulated indicates selectively in cellular response to shear stress in addition to validating the PCR technique. …
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Mechanisms of monohalogenated acetic acid induced genomic DNA damage
… when no damage accumulated in acellular DNA. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was investigated as a possible molecular target for the monoHAAs; each of the monoHAAs inhibited GAPDH with variable efficacy. The ability to inhibit GAPDH correlated strongly with multiple …
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Toxicity mechanism of anthropogenic water contaminants: drinking water disinfection by-products (haloacetic acids) and particle associated contaminants from sealcoats (polyaromatic hydrocarbons) in lake sediments
… that monoHAAs were the strongest inhibitors of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) where, di-, and triHAAs were weaker inhibitors. MonoHAAs greatly reduced the ATP contents of the cells. Unlike monoHAAs, triHAAs increased the cellular ATP levels as compared to the negative controls. …
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Role of Staphylococcus aureus GapC and GapB in immunity and pathogenesis of bovine mastitis
… It has been reported that proteins with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity might be used as such antigens to induce protection against parasitic and microbial infections. Previous study in our laboratory on mastitis-causing streptococci indicates that GapC proteins …
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GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE: A NEW MOLECULAR TARGET IN CHEMOTHERAPY
… of tumor cells through the cell cycle. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) occupies a central position in the glycolytic pathway thus playing a critical role in the energy metabolism of cancer cells. Along with its enzymatic activity, GAPDH is a multifunctional protein which …
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Investigation of the Structure and Kinetics of Heme-Containing Proteins Using Magnetic Circular Dichroism and Rapid-Scan, Stopped-Flow Spectroscopy
… ligands critical for binding the heme cofactor. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme recently implicated in a new role for eukaryotic systems: heme transport protein. Different spectroscopic techniques (UV-Vis and MCD) were employed to identify the axial binding site for …
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Human Papillomavirus DNA extraction and genotype analysis by multiplex real time polymerase chain reaction from formalin fixed paraffin wax-embedded cervical carcinoma specimens
… by endpoint PCR using standard primers for glyceraldehyde 3-phosphate dehydrogenase (GAPDH) sequences to determine the quality and integrity of extracted DNA for downstream PCR amplification experiments. HrHPV DNA amplification was optimised using a touchdown PCR technique with L1 consensus …
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TUMOR PROMOTING FUNCTIONS FOR THE METABOLIC REGULATOR SIRT5
… pathways. One substrate of SIRT5 is carbamoyl phosphate synthase 1 (CPS1), an enzyme involved in the rate-limiting step of the urea cycle. By deacylating CPS1, SIRT5 promotes urea cycle function and clearance of toxic ammonia. Sirt5-deficient mice fail to up-regulate CPS1 activity and show …
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Immune function alterations in Asian elephants (Elephas maximus) infected with Mycobacterium species
… transforming growth factor (TGF)-beta, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and beta actin were determined. Sequence information was then utilized to design elephant-specific, quantitative, real time RT-PCR and in situ hybridization assays for measurement of cytokine mRNA …