Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Glyceraldehyde-3-phosphate dehydrogenase"”.
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GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE: A NEW MOLECULAR TARGET IN CHEMOTHERAPY
… of tumor cells through the cell cycle. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) occupies a central position in the glycolytic pathway thus playing a critical role in the energy metabolism of cancer cells. Along with its enzymatic activity, GAPDH is a multifunctional protein which …
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Molecular characterization and promoter analysis of the maize cytosolic glyceraldehyde 3-phosphate dehydrogenase gene family
… and protein synthesis. Maize cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been identified as one of the anaerobic polypeptides and mRNAs corresponding to a member of the gpc multi-gene family, gpc3, increase under anaerobiosis. This study extends further analysis of the …
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Biophysical characterisation of the interaction between the S.mansoni G4LZI3 protein and the NAD binding domain of glyceraldehyde-3 phosphate dehydrogenase
… for schistosomiasis. Key words: G4LZI3, glyceraldehyde 3-phosphate dehydrogenase, molecular dynamic simulations, Praziquantel, Schistosoma mansoni, .
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The Study of Glyceraldehyde -3 -Phosphate Dehydrogenase (Gapdh) Function Targeted by Estrogen and Progesterone in the Central Nervous System: Physiological Implications
Finally, the epilogue summarizes the results and describes a proposed model for the membrane action of estradiol on GAPDH in the hippocampus that reflects recent interesting reports from other laboratories as well as my own contributions to these novel functions of GAPDH.
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Tyrosine nitration and altered protein pool levels of glyceraldehyde-3-phosphate dehydrogenase following ischemia/reperfusion: The influence of aging in glycolytic skeletal muscle
… that the expression of the glycolytic\r\nenzyme glyceraldehyde-3-phosphate dehydrogenase may be altered following I/R. We\r\nfurther hypothesized that aging would enhance the oxidative stress and oxidative damage\r\nexperienced by the muscle. GAPDH protein levels were measured by Western …
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Glucose metabolism in the outer segments of photoreceptor cells : its involvement in the phototransduction process
… hexokinase, phosphofructokinase, aldolase, glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase, pyruvate kinase, and lactate dehydrogenase, were found to be present in purified rod outer segment preparations in quantities similar to that found in human red blood cells. …
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Serine/threonine phosphorylation in mycobacterium tuberculosis : identification of protein kinase B (PknB) substrates
… identified a previously unknown phosphoprotein glyceraldehyde 3-phosphate dehydrogenase encoded by the ORF Rv1436, which demonstrates autophosphorylation activity and which phosphorylation is independent of PknB. Overall, the current study has contributed to advance our understanding of the …
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Physiological and Biochemical Response of Saccharomyces cerevisiae to Desiccation and Rehydration
… response. Molecular analysis focused on glyceraldehyde-3-phosphate dehydrogenase (GAPDH, E.C. 1.2.1.13), a multifunctional protein that is involved in several cellular processes other than glycolysis, including nuclear translocation under stress and intracellular sensing of oxidative …
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Gene expression profile of ethanol-stressed yeast in the presence of acetaldehyde
… from accumulated NADH. This, in turn, stimulates glyceraldehyde-3- phosphate dehydrogenase activity and might account for the acetaldehyde-mediated increased expression levels of pyruvate decarboxylase genes; elevated levels of pyruvate would potentially increase the need for PDC activity. …
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Functional analysis of the CP12 gene family in Arabidopsis
… two enzymes of the Calvin-Benson cycle, namely glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase (PRK). The regulation of these enzymes is achieved by the reversible formation of this multiprotein complex in response to a change in light intensity. In Arabidopsis, there …
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Enzyme Analysis of Oxidatively Modified Proteins Post-TBI
… of energy related and salvage related enzymes, glyceraldehyde-3-phosphate dehydrogenase, pyruvate kinase, lactate dehydrogenase, aspartate aminotransferase, malate dehydrogenase, cytochrome C oxidase, ATP synthase, and hypoxanthine-guanine phosphoribosyltransferase, that have been identified as …
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Genetic association between schizophrenia and type-2 diabetes
… (HKGs), beta-actin (ACTB) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) were used as the internal controls to normalize the Ct values of the target genes. Fisher’s combining probability test was used to determine the combined p values from the Student’s t-tests for two …
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The synthesis and in vitro evaluation of siRNAs modified at the backbone with a novel triazole-based internucleotide linkage and abasic alkyl-chain linkages of varying length
… gene firefly luciferase and the endogenous gene glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in a dose-dependent manner. In addition, modifying the 3′- overhangs of siRNAs with the triazole backbone linkage, gave rise to increased nuclease resistance well beyond that of wild-type siRNA. …
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A novel system to study seed recalcitrance and dormancy - comparative proteomics between two Spartina species
… chaperones, antioxidants, cystatin, and glyceraldehyde-3-phosphate dehydrogenase. These data suggest that LEA prevention pathways, molecular chaperone rescue pathways, ubiquitin-proteasome and autophagy degradation pathways and ROS-antioxidant systems may account for the desiccation …
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Cellular Responses in ESCHERICHIA COLI to Lethal and Sublethal Doses of Ozone
… plasmid DNA, remained intact. The enzymes malate dehydrogenase, lactate dehydrogenase and glutathione disulfide reductase were unaffected, while glyceraldehyde-3-phosphate dehydrogenase activity decreased significantly. Glutathione and total sulfhydryl compounds were also very sensitive to ozone …
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Copper as an Antibacterial Agent and Disruptor of Protein Stability
… protein targets such as the metabolic enzymes glyceraldehyde-3-phosphate dehydrogenase and isocitrate dehydrogenase, whose activities were confirmed to be inhibited by PT-induced copper toxicity in enzymatic assays. Finally, the impact of Cu on the proteome was further investigated in a …
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Molecular adaptation to low-temperature in New Zealand stick insects
… identifying two (phosphoglucose isomerase and glyceraldehyde 3-phosphate dehydrogenase) that encode branch-point enzymes linking glycolysis to the pentose phosphate pathway as under positive selection. These results indicate adaptation to stressful lifestyles requires a balance between …
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Protein Set for Normalization of Quantitative Mass Spectrometry Data
… cellular functions such as actin, tubulin and glyceraldehyde-3-phosphate dehydrogenase, are frequently utilized as internal controls in biological experiments. However, recent studies have shown that the expression level of such commonly used housekeeping proteins is dependent on cell type, …
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Proteomic Analysis of Human Mesenchymal Stem Cell Aging during serial sub-culture
… searching. It was observed that Calreticulin, Glyceraldehyde-3-phosphate dehydrogenase, and alpha-crystallin B chain were up regulated in protein expression while Moesin (C-terminal frag), ii Poly (rc)-binding protein, Alpha-tropomyosin, Annexin A2, and Galectin 3 were down regulated. …
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Incomplete concerted evolution in the non-hybrid diploid Clematic fremontii S. Watston (Rananculaceae)
… same populations using single-copy nuclear gene glyceraldehyde 3-phosphate dehydrogenase (G3pdh) sequence data. While the data set for this gene region is incomplete, it appears that G3pdh is single copy in Clematis fremontii and variable enough to get at the original goals of this thesis …
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