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Showing 1 to 20 of 166 for “"Glycans"”.
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Decoding structure-function relationships of glycans
Glycans are an important class of biological molecules that regulate a variety of physiological processes such as signal transduction, tissue development and microbial pathogenesis. However, due to the structural complexity of glycans and the unique intricacies of glycan-protein interactions, …
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Bioinformatics and database tools for glycans
… in modulating cellular activities. Glycosaminoglycans (GAGs) are one such family of polysaccharides that play a very important role in regulating the functions of numerous important signaling molecules and enzymes in the cell. Developing bioinformatics tools has been integral to advancing …
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Harnessing N-glycans as Next Generation Prebiotics
N-linked glycans are structurally diverse carbohydrate moieties that are covalently boundto dietary glycoproteins. Upon ingestion, N-glycans from dietary glycoproteins escape absorption in the small intestine and travel to the colon for fermentation. Ample evidence has indicated that certain …
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Analysis of glycans and glycoproteins by mass spectrometry
… herein to obtain structural information from glycans. There are two common ways of characterizing glycans by mass spectrometry. The first method involves releasing glycans from protein, purification followed by mass spectrometric analysis. The second approach involves the analysis of …
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Mucin and mucin glycans alter behaviorof mucosal pathogens
… devices. Additionally, I discover that the glycans cleaved from the mucin protein backbone also block K. pneumoniae attachment to abiotic surfaces, suggesting the possibility of mucin mimetics to prevent biofilm formation on medical devices. My second project examines the primary pathogen …
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The regulation of bacterial virulence by mucin glycans
… that forms the mucus gel. Upon sensing the O-glycans displayed mucin, opportunistic pathogens can alter their gene expression, and are less likely to engage in virulence behaviors like biofilm formation and toxin production. Therefore, mucin gels can be considered a sophisticated bioactive …
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Role of oviduct glycans in sperm binding and fertilization
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Some non-cellulosic b-D-Glycans from plant sources
The structures of some non-cellulosic β D-Glycans from three plant sources have been investigated and each was found to be characterised by linked D-pyranosyl a main chain consisting of β -(1-44)- sugars. The polysaccharides were, however, different in structural features in a manner apparently …
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Chemical Biology Tools to Study Bacterial Cell Surface Glycans
Cell surface glycans are ubiquitous and serve as the first point of contact between a cell and the surrounding environment. Many of the carbohydrate-mediated interactions that occur at this interface regulate key signaling processes such as cell-cell recognition, communication, and adhesion. …
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Glycans in host-pathogen interactions : an integrated biochemical investigation
… matrix interface primarily comprises of complex glycans and glycoconjugates. The widespread distribution of these glycans on the epithelial cell surface makes them ideal targets for interaction with microbial pathogens. In this thesis, a framework of integrated approaches was developed to …
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The influence of mucin glycans on microbial virulence and competition
… I study the ability of mucin and their attached glycans to regulate interactions between a clinically-important opportunistic pathogen, Pseudomonas aeruginosa, and its host. I then investigate the underlying genetic mechanisms that enable P. aeruginosa to sense and respond to the mucus …
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Methods for the structural modification and characterization of bacterial glycans
… processed, and displayed in cellular glycans in the early 1990s led to the development of metabolic incorporation probes for mammalian and microbial organisms. Taking advantage of the development of rapid, bioorthogonal chemistries these probes have provided valuable insight into …
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Characterization of Glycans Derived from Biological Samples Using LC-MS/MS
… types of cancer. Given the essential nature of glycans in crucial biological functions and their association with various health conditions when their expressions are altered, glycomics are becoming leading areas in the development of biomarkers. These biomarkers present unique opportunities to …
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Analyzing the Role of Mucin O-Glycans in Regulating Microbial Virulence
… by investigating how mucins and their associated glycans influence microbial physiology in the opportunistic fungal pathogen, Candida albicans, and the gram-negative bacterial pathogen, Vibrio cholerae. First, I purify and characterize libraries of mucin-attached glycans and establish their role …
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Roles for cell surface glycans in guiding human pluripotent stem cell fate
Cell-surface polysaccharides are a fundamental component of the stem cell microenvironment. They are known to modulate developmental signals- critical for pluripotency and differentiation. Nevertheless, the architecture of the cellular glycocalyx and how these structures direct the fate of human …
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The Development of Novel Tools for the Metabolic Labelling of Glycans in Cancer
Aberrant cell surface glycosylation is key in tumour proliferation, metastasis, and immune evasion, with hypersialylation one of the alterations most observed in tumour cells. Changes in the glycome can be monitored by incorporating unnatural sugars bearing bioorthogonal chemical reporters. …
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Porcine sperm binding to oviduct cells and glycans as supplements to laboratory semen analysis
Made available in DSpace on 2017-09-29T16:39:04Z (GMT). No. of bitstreams: 2 WINTERS-THESIS-2017.pdf: 2139345 bytes, checksum: fefd923307c810e3b0ef703e67f7f783 (MD5) LICENSE.txt: 4212 bytes, checksum: 2f272282614c94c4f29c0cea4830b940 (MD5) Previous issue date: 2017-05-30
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Understanding the role of different strain types of Fusobacterium necrophorum: biofilms, glycans and metabolic pathways
… resistant to penicillin and ciprofloxacin. As glycans are implicated in biofilm formation, bacterial adhesion to host cells and pathogenicity, the cell surface glycans and cell extracts of F. necrophorum were investigated using enzyme-linked lectin assays (ELLA) and lectin histochemical …
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Emerging out of the “blur”: exploration, evaluation and significance of 3D N-glycans’ structure through molecular dynamic studies
… stability and dynamics, and function. Complex N-glycans are a class of glycans found in eukaryotes, sharing a common pentasaccharide core structure. The functionalization of the arms and the branching patterns are specific to different species, while the complexity of the cellular biosynthetic …
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