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Showing 1 to 7 of 7 for “"Glycan binding proteins"”.
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Directed Evolution of Glycan-Binding Proteins
Glycan-binding proteins (GBPs) are commonly used reagents for the study of glycans. They do not require specialized equipment or time-consuming experimental methods, making them widely used tools for basic research and clinical applications. Existing glycan recognition reagents,antibodies and …
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DESIGNING A PLATFORM FOR DEVELOPING NOVEL GLYCAN-BINDING PROTEINS USING YEAST SURFACE DISPLAY
Glycans are sugar molecules present ubiquitously in all living organisms. Their abnormal expression in diseases such as cancer, use by pathogens to infect host cells, and roles in the immune system makes them important targets for the design of therapeutics and diagnostics. However, a major …
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Study of Glycan-Mediated Interactions by Photocrosslinking GlcNAc and GalNAc Analogs
Glycans, along with nucleic acids, proteins and lipids, are essential elements of life. Glycans are involved in multiple biological processes, such as cell signaling, cell adhesion and host pathogen interactions, many of which are achieved through interactions with other molecules, especially …
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Interpretable Supervised Learning and Graph-Based Optimization for Glycan-Lectin Binding
Non-linear biological macromolecules, such as glycans, participate in a wide range of key structural, metabolic, and regulatory functions in all living organisms. Many of these essential roles involve interactions with glycan-binding proteins called lectins. As a result, there is particular …
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Decoding structure-function relationships of glycans
Glycans are an important class of biological molecules that regulate a variety of physiological processes such as signal transduction, tissue development and microbial pathogenesis. However, due to the structural complexity of glycans and the unique intricacies of glycan-protein interactions, …
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Development of Chemical Tools to Discover and Characterize Sialic Acid Mediated Interactions
… refers to the addition of carbohydrates onto proteins, lipids, and other biomolecules. Proteins and lipids on the cell surface are frequently found to be glycosylated. This glycosylation can have a number of functions, one of which is to mediate specific binding interactions between the …
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The Role of Galectin-3 in Pathogen Sensing and Cell Autonomous Defense
… to the host cytosol. Galectins, cytosolic host glycan binding proteins, are then able to recognize the exposed sugars and bind them. Subsequently, host defense proteins including the guanylate binding proteins (GBPs) are recruited to the damaged membrane. I propose that this damage sensing …