Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Glutathione synthetase"”.
-
Glutathione synthetase: Conserved residues of the substrate loop
The important antioxidant tripeptide glutathione (GSH) is synthesized in two ATP-dependent steps; the second enzyme in the biosynthetic pathway, glutathione synthetase (GS), ligates glycine to γ-glutamylcysteine (γ-GC). Human glutathione synthetase (hGS) deficiency causes hemolytic anemia, …
-
The Role of Glutathione Synthetase in Trypanothione Biosynthesis in Trypanosoma brucei
… a novel cofactor termed trypanothione instead of glutathione for protection against reactive oxygen species. Trypanothione is formed by the conjugation of two molecules of glutathione to spermidine forming a link between the polyamine and thiol biosynthetic pathways. My work has investigated the …
-
Untersuchungen zur Struktur und Funktion der Glutathionsynthetase bei der Spalthefe Schizosaccharomyces pombe
In the literature the enzyme glutathione synthetase of the fission yeast S. pombe had been described - in contrast to the homodimeric enzymes of other eucaryotic organisms - as a heterotetramer composed of two „large” 33 kDa and two „small” 26 kDa subunits. The „large” subunit had been assigned to …
-
Metals in Chemistry and Biology: Computational Chemistry Studies
… and describes modeling studies performed on glutathione synthetase. (1) Copper nitrene complexes were computationally characterized, as these complexes have yet to be experimentally isolated. (2) Multireference calculations were carried out on a symmetric C2v chromium dimer derived from the …
-
A study of the beneficial role of thiol antioxidant supplementation in various forms of glutathione deficiency
… to protect cells from the harmful effects of glutathione depletion in two different models of oxidative stress. The first model represented oxidative stress processes in age-related macular degeneration. This part of the study focused on the protective effects of NACA on t-butyl hydroperoxide …
-
Digestible methionine + cysteine:digestible lysine ratio in diets for broilers submitted to inflammatory challenge
… mRNA content of nuclear factor kappa-B (NF-Κb), glutathione peroxidase (GPX), superoxide dismutase (SOD), glutathione synthetase (GSS), methionine adenosyltransferase (MAT2), cystathionine β-synthase (CBS), relative weights of liver and spleen, and dual-energy x-ray absorptiometry (DEXA) …
-
Redox Homeostasis in Cyanobacteria
… photosynthetic organisms from the threat of ROS. Glutathione: GSH) is a multifunctional molecule that is involved in core metabolism, detoxification of xenobiotics and in maintenance of cellular redox poise. The ubiquitous nature of glutathione and its importance to cellular metabolism has been …
-
Glutathione metabolism of Plasmodium falciparum
… of resistance in the future. The tripeptide glutathione (GSH) or γ-glutamylcysteinyl-glycine is the most abundant low molecular weight thiol in most eukaryotic organisms and serves a number of important functions as sulfhydryl-buffer, cofactor for enzymes and for the detoxification of …