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Showing 1 to 2 of 2 for “"Glutaminyl cyclase"”.
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The Isolation of Native Glutaminyl Cyclase from Saccharomyces cerevisiae
Glutaminyl Cyclase (QC)(2.5.2.3) catalyzes the cyclization of the N-terminal glutamine residues of peptides and proteins. Recent interest in QC has been generated by studies that have linked QC activity in human neuroendocrine tissue to diseases such as Alzheimer's and osteoporosis. While QC has …
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Mechanisms of Non-Enzymatic Peptide Bond Formation: Thioester and Transamidation Routes
… modular enzyme complex and in the enzyme glutaminyl cyclase were also used for spontaneous peptide (amide) synthesis in a buffered, abiotic solution. Analytical analyses revealed that spontaneous peptide (amide) bond formation occurred under mild prebiotic conditions during both the …