Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Glutamine Metabolism"”.
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Myc influences glutamine metabolism to induce autophagy in tumorigenesis
… cells. The direct connection between Myc, glutamine metabolism and autophagy and their role in competitive events between cancerous cells and wild type cells have not been clearly explained; therefore, the main purpose of this project is to determine a plausible link between Myc and …
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Targeting Glutamine Metabolism in Kidney Development and Polycystic Kidney Disease
… Lkb1 mutant cells and embryonic kidneys require glutamine for growth while wild-type cells and kidneys did not. Subsequent studies demonstrated that Pkd1 embryonic kidneys phenocopied Lkb1 mutant kidneys in respect to their reliance on glutamine for growth. Further investigation into defining …
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Reductive Carboxylation Is a Novel Pathway of Glutamine Metabolism That Supports the Growth of Tumor Cells with Metabolic Defects
In growing cancer cells, oxidative metabolism of glucose and glutamine in the mitochondria provide precursors needed for de novo synthesis of proteins, nucleic acids and lipids. Yet, a subset tumors harbor genetic mutations in the electron transport chain or tricarboxylic acid cycle that disable …
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Antioxidant Programs Are Essential for Enzalutamide-Resistant Prostate Cancer
… Unbiased metabolomic evaluation identified that glutamine metabolism was consistently upregulated in enzalutamide-resistant PCa cells and CRPC tumors. Stable isotope tracing studies suggest that this enhanced glutamine metabolism drives an antioxidant program that allows these cells to tolerate …
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Glutamine Antagonism and Its Utlity [sic] as a Therapeutic Modality in Cancer
Glutamine metabolism is important in cancer as it fuels the TCA cycle, plays a role in redox homeostasis, and contributes to the production of nucleotides, amino acids, and lipids for survival, making glutamine metabolism a promising target in cancer therapy. The work outlined in this dissertation …
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The Contextual Roles of Isocitrate Dehydrogenase-1 and Isocitrate Dehydrogenase-2 in Electron Transport Chain Complex III Deficiency
Inborn errors of metabolism provide excellent opportunities in translational research, because individual clinical cases can stimulate insights that lead to a deeper understanding of human metabolism and sometimes inform personalized patient care. Our clinical genetics team identified a female …
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Elucidating the Target and Selectivity of a Non-Small Cell Lung Cancer Toxin
… content of aspartate formed via reductive glutamine metabolism promotes resistance to mitochondrial inhibition. Altered metabolism is an important feature of cancer and there is significant interest in understanding how differences in tumor metabolism can be exploited for therapy. NSCLC …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… enzyme activity, and underscore cellular metabolism. When redox poise fails and cells are overcome by oxidation, cellular death soon follows. Redox biology is an especially important aspect of cancer cell biology, because oncogene-induced hyperproliferation results in pro-oxidant tumor …
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Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer
… therapeutic options are limited. A dependence on glutamine metabolism, <em>via </em>the enzyme glutaminase (GLS), is a known mechanism of adaptive resistance.</p> <p><strong>Purpose: </strong>To assess the efficacy of a glutaminase inhibitor as a means of exploiting the metabolic vulnerability of …
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Integrated characterization of cellular physiology underlying hepatic metabolism
… approach for the characterization of hepatic metabolism. First, we implemented a novel method for functional genomics. The metabolic response of hepatoma cells to the depletion and repletion of glutamine was characterized in time course measurements of metabolic fluxes and metabolite pool …
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The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… normal adipose tissue, FOXC2 regulates adipocyte metabolism by promoting the expression of genes associated with energy turnover, insulin sensitivity, differentiation, and mitochondrial biogenesis. I hypothesized that similar to its regulatory role of adipocyte metabolism, FOXC2 dictates metabolic …
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Zein films as substrates for cell attachment
… CTC’s from the blood stream. Numerous studies on glutamine metabolism in cancer indicate that many tumors are avid glutamine consumers in vivo and in vitro. Prolamins are a group of plant seed proteins having high glutamine content. A main example is corn zein. Zein has been reported to support …
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A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death
… implications of these data and the role of metabolism in prostate cancer incidence, we evaluated resveratrol in an in vitro disease progression model of prostate cancer and found that castration-resistant human prostate cancer C4-2 cells are more sensitive to resveratrol-induced apoptosis …
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Mitochondrial metabolism in cancer transformation and progression
… undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological implications and clinical relevance are unclear. In this study, I systematically analysed …
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In Vivo Kinome Screen Reveals Non-Canonical Cdk-Driven Metabolic Adaptation In Brain Metastasis
… a potential link between PCTK1 expression and glutamine metabolism and I demonstrated that the growth advantage conferred by PCTK1 was due to increased glutamine consumption by the cancer cells. Knockdown of PCTK1 in the brain metastatic HCC1954Br breast cancer cell line increased mouse …
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… reprogramming, wherein cancer cells rewire their metabolism for growth and survival, is a critical area of interest. Developing anti-metabolic drugs is an emerging field that targets the upregulated metabolic dependence of cancer. The liver X receptors (LXR) are ligand-modulated nuclear receptors. …
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Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype
… stem cells (CSCs) and de-regulated cellular metabolism have become appreciated for their crucial roles in the development, growth, and therapy resistance of tumors, and are now being pursued as therapeutic targets for the treatment of cancer. To better understand how these oncogenic events …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… activation, immunosuppression, and enhanced glutamine metabolism. IACS-010759 treatment and treatment with the novel glutaminase inhibitor CB839 significantly improved the survival of mice bearing High-OXPHOS, MAPKi-resistant ICr xenografts.</p> <p>Together these studies indicate that the …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… We found that SCLC cells are dependent on glutamine metabolism for cell viability and proliferation, in a HIF-independent fashion. The SCLC cells used here are MYC and MYCL amplified and MYC overexpression is known to stimulate glutaminolysis and lipogenesis. In HIF1A repressed cells that …
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