Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Glutamates"”.
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A New Synthesis of enantiopure C-3-substituted Glutamates by Utilization of Ortho Ester protected (S)-Pyroglutamic acid
… generate various enantiopure C-3-substituted pyroglutamates as well as C-3-substituted glutamates, and furthermore to ameliorate the serious drawback of the bad atom-economy in the reaction sequence of previously published silylether-mediated procedures. To meet these requirements, the ortho ester …
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Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
… members of the superfamily, rings of glutamates (and, more rarely, aspartates) that line the ion-permeation pathway are responsible for increasing the single-channel conductance. Among these rings, one in particular, at the intracellular mouth of the pore, catalyzes the movement of …
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Functional Characterization of the HIV-1 NEF Acidic Cluster
… at least one or more of the four acidic cluster glutamates are involved not only in MHC-I downregulation, but also Pak2 activation and infectivity enhancement. However, because partial activity is observed with one acidic residue and full activity with only two acidic residues, these data lead to …
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Novel Fluorescent Sensors for Dynamic Intracellular Signalling
… These were mutated systematically to alanines or glutamates. Comparison of responses from the different mutants showed a) that one specific serine in KCP-1 was necessary and sufficient to produce a maximal response and b) that these three amino acids contributed differently to the FRET change. …
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Characterization of neural progenitor cells of the embryonic and adult dorsal root ganglia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Assessment of potential antibacterial drug targets
… protein for the synthesis of folyl-poly-glutamates, a reference pathway for drug development. A new enzymatic assay, using malachite green, has been identified and used to confirm <i>Y. pestis</i> FolC activity. Such an assay could be used to determine kinetic parameters and to develop a …
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Mechanistic studies of class II lanthipeptide synthetases and yeast surface display of lanthipeptide leader peptides
… that they are typically rich in aspartates and glutamates. The leader peptide is believed to be recognized by the biosynthetic enzymes and guide the process of the post-translational modifications. Moreover, it is proposed that the binding of leader peptides to the enzymes shifts the equilibrium …
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Sortases: Keystones to Virulence and Targets for Anti-Infective Therapy
… is likely catalyzed by adjacent conserved glutamates. A direct nucleophilic attack mechanism, starting from an inverse protonation state, is supported in this study. Of note, there appears to be temporal regulation of isopeptide bond formation in the different domains of <italic>S. …
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The Evolution of Photosystem II Subunit S across the Green Lineage
… to Q183 in Arabidopsis) as well as two glutamates in the lumenal loops which are closely situated to the two already identified in previous studies to be instrumental to function. Excitingly, mutation to the ancestral state, glycine (Q183G), significantly reduced the maximal NPQ, while …
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Elucidation of the Specificity of S. meliloti Chemoreceptors for Host Derived Attractants
… aspartate 155 and aspartate 182 are changed to glutamates. The periplasmic region of wild type McpU was purified and demonstrated to directly bind proline with a dissociation constant (Kd) of 104 μM. The variant McpU proteins show a reduction in binding affinity confirming McpU as a direct …