Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Glutamatergic synapses"”.
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Regulation of Molecular Composition at Glutamatergic Synapses
… is necessary for the formation of functional glutamatergic synapses. Here I examined the clustering of presynaptic (Brain-Specific L-Proline Transporter, PROT) and postsynaptic (N-Methyl-D-Aspartate Glutamate Receptor, NMDAR) molecular markers in rat hippocampal cultured neurons. PROT …
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Synaptome mapping of glutamatergic synapses across the mouse brain
Synapses are specialised contacts between neurons. At postsynaptic terminals of glutamatergic synapses, protein complexes process and transmit the information received from the presynaptic terminal. Scaffolding proteins, among which members of the disc large homologue (DLG) family are the most …
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BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex
Synapses are the fundamental units of communication in the brain, and their proper development and function are critical for cognitive processes and behavior. While the development of glutamatergic synapses has been extensively studied, the mechanisms underlying the formation of the tripartite …
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Uncovering the Connectome
… (AT) in the last decade, our ability to study synapses and their proteometric composition in the mammalian cortex has skyrocketed. However, unlike electron microscopy (EM) data which is the gold standard for synapse detection, AT data presents a variety of challenges in visualizing and …
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Imaging Neuromuscular Synaptogenesis
… coordinate postsynaptic molecular assembly at glutamatergic synapses. Genetic studies demonstrate their role during synaptic maintenance and plasticity. However, it is unclear whether initial synaptogenesis requires PSD-95/Dlg and, if so, how its function collaborates with cell-specific …
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Rapid diffusion in the brain extracellular space - biophysical constraints and physiological implications
… biophysical models have shown that, in central glutamatergic synapses, changes in extracellular diffusivity or glutamate transporter functions exert significant influences on the excitatory transmission. Failures of transporter functions have also been related to neurological disorders. The …
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Screen for Suppressors and Enhancers of Excitotoxic Neurodegeneration
… and is triggered by excessive stimulation of glutamatergic synapses. In spite of extensive studies, the molecular mechanisms involved in excitotoxicity following the over-activation of postsynaptic glutamate receptors are not well understood, and clinical trials based on our partial …
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Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
… occurs at specialised sites, known as synapses. Presynaptic neurotransmitter release from one neuron acts on the postsynaptic receptors of another, facilitating transfer of electrical impulses between neurons. At glutamatergic synapses, ionotropic glutamate receptors (iGluRs) respond to …
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Regulation of Synaptic Vesicle Trafficking at Central Synapses
Synapses are where electrical information is converted to chemical signaling, allowing for careful regulation of inter-neuronal communication in the brain. At presynaptic terminals, synaptic vesicles fuse with plasma membrane in response to electrical stimulation, followed by rapid retrieval to the …
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Genetic Dissection of Synaptic Vesicle Endocytosis
… frequency of spontaneously released events in glutamatergic synapses, I observe no discernable defects in GABAergic neurotransmission. This result suggests inhibitory synapses are better equipped with compensatory mechanisms to deal with the loss of dynamins 1,2 and 3. Overall, my data …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… elimination, maintenance, and plasticity of synapses. During early postnatal development, excess synapses are formed in most neural circuits, which are subsequently pruned during adolescence in a sensory- and activity-dependent mechanism. The brain also exhibits experience-dependent synaptic …
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Touching Autism Spectrum Disorder: Somatosensory Abnormalities in Shank3b and Cntnap2 Mouse Models
… in the structure of the postsynaptic density of glutamatergic synapses. In humans, haploinsufficiency of SHANK3 causes the Phelan-McDermid syndrome, a neurodevelopmental disorder characterised by ASD-like behaviour, developmental delay, intellectual disability and absent or severely delayed …