Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Glutamate Transporter"”.
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STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER
<p>Glutamate transporters have a homotrimeric subunit structure with a large central water-filled cavity that extends partially into the plane of the lipid bilayer (Yernool et al., 2004). In addition to uptake of glutamate, the transporters also mediate a chloride conductance that is gated by Na+ …
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STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER
<p>Glutamate transporters have a homotrimeric subunit structure with a large central water-filled cavity that extends partially into the plane of the lipid bilayer (Yernool et al., 2004). In addition to uptake of glutamate, the transporters also mediate a chloride conductance that is gated by Na+ …
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PHYSICO-CHEMICAL STUDIES OF THE VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1)
The vesicular glutamate transporter 1 (VGLUT1) is an important membrane protein located in glutamatergic synaptic vesicles. It is responsible for the storage and release of the excitatory neurotransmitter glutamate. VGLUT1 is a highly hydrophobic integral membrane protein with a molecular weight …
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PHYSICO-CHEMICAL STUDIES OF THE VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1)
The vesicular glutamate transporter 1 (VGLUT1) is an important membrane protein located in glutamatergic synaptic vesicles. It is responsible for the storage and release of the excitatory neurotransmitter glutamate. VGLUT1 is a highly hydrophobic integral membrane protein with a molecular weight …
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The vesicular glutamate transporter (VGLUT): heterologous expression, proteoliposome, computational and mass spectral studies
<P>Vesicular glutamate transporters (VGLUTs) are integral membrane proteins that uptake glutamate into synaptic vesicles and are involved in glutamatergic neurotransmission. Since VGLUTs were identified and cloned, efforts have been made to characterize their functional roles. However, due to …
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The vesicular glutamate transporter (VGLUT): heterologous expression, proteoliposome, computational and mass spectral studies
<P>Vesicular glutamate transporters (VGLUTs) are integral membrane proteins that uptake glutamate into synaptic vesicles and are involved in glutamatergic neurotransmission. Since VGLUTs were identified and cloned, efforts have been made to characterize their functional roles. However, due to …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
As the primary excitatory amino acid, glutamate is essential to proper functioning of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
As the primary excitatory amino acid, glutamate is essential to proper functioning of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the …
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Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
Precise regulation of glutamate homeostasis is critical for normal brain function, as its disruption can impair excitatory transmission and result in neurodegenerative and neuropsychiatric disorders. Critical to maintaining glutamate homeostasis is a family of sodium-dependent glutamate …
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The JBS-associated E3 Ligase UBR-1 Maintains Synaptic Glutamate Homeostasis and Regulates Neurotransmitter Balance
… I find that the absence of UBR-1 disrupts glutamate homeostasis, and further identified three components of a UBR-1-regulated signaling pathway - a glutamate metabolic enzyme GOT/GOT-1.2, a vesicular glutamate transporter VGlut3/EAT-4, and a glutamate-gated chloride channel GluCl/AVR-15 - …
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Genomic Discovery of recurrent CD44-SLC1A2 Gene Fusion in Gastric Cancer
… genomic breakpoints in the SLC1A2/EAAT2 glutamate transporter. 5' RACE analysis of a breakpoint-positive cell line (SNU16) revealed expression of a CD44-SLC1A2 fusion transcript, caused by a paracentric chromosomal inversion, which was predicted to produce a truncated but functional …
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Functions of Mediodorsal Thalamic Astrocytes in Cue-Based Learning
… and late stages, the density of astrocytes, glutamatergic nerve terminals, and astrocyte glutamate transporter proteins will be examined. We found that MD astrocytic calcium activity responds to the initial cue and the reward, suggesting that this activity mediates the temporal dynamics of …
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A Role for glutamate and Gaba in attention-deficit/hyperactivity disorder: a study of the spontaneously hypertensive rat
… and inhibitory neurotransmitters in the brain, glutamate and GABA respectively, play a role in the dysregulation of the norepinephrine system in a rat model of ADHD, the spontaneously hypertensive rat (SHR), compared to its control strain, the Wistar-Kyoto rat (WKY), and a third comparator …
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Rapid diffusion in the brain extracellular space - biophysical constraints and physiological implications
… biophysical models have shown that, in central glutamatergic synapses, changes in extracellular diffusivity or glutamate transporter functions exert significant influences on the excitatory transmission. Failures of transporter functions have also been related to neurological disorders. The …
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
… progenitor pools of different aged mice. GltI, a glutamate transporter, was identified as a candidate which was upregulated 10 fold in progenitors from older animals. In astrocytes, GltI and Glast are required to maintain low levels of glutamate to prevent overstimulation of glutamate receptors. …
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Prognostic Significance of Xct Polymorphisms and Expression In Patients With Advanced Pancreatic Cancer Treated With Chemotherapy
… membrane x<sub>c</sub><sup>-</sup> cystine/glutamate transporter mediates cellular uptake of cystine in exchange for intracellular glutamate and is highly expressed by pancreatic cancer cells. The <em>xCT</em> gene, encoding the cystine-specific xCT protein subunit of …
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Characterization of subtypes of precursor cells in the developing central nervous system
… of the antigens RC2, the astrocyte-specific glutamate transporter (GLAST) and the brain lipid-binding protein (BLBP). In addition, from on late neurogenesis GLAST- and BLBP-antisera label precursor cells with non-radial, but stellate morphology and thereby cover almost the entire progenitor …
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The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
Alterations in the strength of glutamatergic synaptic activity shape the synaptic localization of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs), and this process is thought to underlie higher brain functions such as learning and memory. During …
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Effect of metabolic insult on amino acids in the ciliary epithelium, lens, and retina
… cell resolution. The results showed that a glutamate/glutamine cycle exists between the ciliary epithelium and lens, in analogy to the metabolic relationship between neurons and glia in the retina. with the localisation of glutamine synthetase and glutamate transporters, amino acids …
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Longitudinal Metabolic and Proteomic Changes Studied in an Experimental Model of Traumatic Brain Injury
… significant events are increased utilization of glutamate oxidation, perturbations to glucose and one carbon metabolism, energy failure, impairment of antioxidant capacity, blood-brain barrier BBB breach and elevated glial acidic fibirillary protein (GFAP). GFAP levels remain elevated in the …
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