Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Glutamate Toxicity"”.
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Analyzing A-series gangliosides in neurons following exposure to glutamate
… in rat primary cortical neurons exposed to glutamate toxicity. Primary embryonic (E18) rat cortical neurons were cultured to DIV14. Glutamate toxicity was induced for 1, 3, 6 and 24 h. Immunofluorescence was used to stain for GM1 and GM3 species and ESI-MS was used to quantify the …
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Synthetic Studies Towards Mescengricin
… chick primary mesencephalic neurons from L-glutamate toxicity with an EC50 of 6.0 nM. A model study was conducted to obtain the oxazoloindole to attempt the intermolecular aza- Diels-Alder reaction. Treatment of 250 to the Robinson-Gabriel cyclodehydration gratifyingly afforded 259. Though …
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Using Hi-Spots to investigate in vitro network dysfunction in Cysteine String Protein ? knockout mice
… increases with time in culture and is blocked by glutamate receptor antagonists and stimulated by the inhibitory receptor antagonist bicuculline. The validity of its more in vivo-like organization, not observed in more conventional dissociated cultures, is evidenced by a glutamate toxicity …
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Pharmacology of a novel biased allosteric modulator for NMDA receptors
NMDA glutamate receptor is a ligand-gated ion channel that mediates a major component of excitatory neurotransmission in the central nervous system (CNS). NMDA receptors are activated by simultaneous binding of two different agonists, glutamate and glycine/ D-serine1. With aging, glutamate …
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Roles of interleukin-1 beta in glutamate-induced spinal cord injury
Glutamate release contributes to the impairments caused by spinal cord injury (SCI). This study addresses the mechanisms of glutamate toxicity involving activation of interleukin-1â (IL-1â). To assess the effects of glutamate on IL-1â and its natural blocking agent interleukin-1 receptor antagonist …
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Newly Synthesized Pyroglutamate Amide and its Neuroprotective Effect Against Neurotoxicity Induced Cell Death in Alzheimer's Disease
… cell death. The common pathway is the excitotoxicity, a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity leading to the cell death. One of …