Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 118 for “"Glutamate Receptors"”.
-
Functional Analysis of Plant Glutamate Receptors
The plant glutamate receptors (GLRs) are homologs of mammalian ionotropic glutamate receptors (iGluRs) and are hypothesized to be potential amino acid sensors in plants. Since their first discovery in 1998, the members of plant GLRs have been implicated in diverse processes such as C/N ratio …
-
Conformational Changes In The Extracellular Domain of Glutamate Receptors
<p>The family of membrane protein called glutamate receptors play an important role in the central nervous system in mediating signaling between neurons. Glutamate receptors are involved in the elaborate game that nerve cells play with each other in order to control movement, memory, and …
-
Super-resolution imaging of glutamate receptors trafficking at live synapses
… signals (neurotransmitters) from presynapse via glutamate receptors, mainly AMPA receptors and NMDA receptors. Trafficking of AMPA receptors in and out of synapses affect synaptic plasticity, which underlies the molecular mechanism of learning and memory. Lateral diffusion of AMPA receptors near …
-
Contributions of metabotropic glutamate receptors to the pathophysiology of autism
… protein synthesis downstream of metabotropic glutamate receptor 5 (mGluR5) is a shared disruption in these disorders, and therefore may ultimately contribute to the pathophysiology of ASD in general. First, we show that multiple aspects of mGluR-mediated protein synthesis are altered in the …
-
The Effect of L-Proline on Two Recombinant AMPA Glutamate Receptors
… been shown to be a low affinity agonist at glutamate and glycine receptors. Because schizophrenia is thought to arise from glutamate receptor hypofunction and l-proline can act at glutamate receptors, it is necessary to understand whether increase in l-proline can contribute to glutamate …
-
Visualizing the dynamics of ionotropic glutamate receptors using atomic force microscopy
Glutamate is the major excitatory neurotransmitter in the mammalian brain. It binds to three different subclasses of ionotropic glutamate receptors (iGluRs): AMPA, kainate and NMDA receptors, and triggers a cation influx that generates synaptic currents crucial to brain function. Significantly, …
-
GROUP I METABOTROPIC GLUTAMATE RECEPTORS ON SELECTIVE CELLULAR SUBTYPES IN EPILEPTOGENIC MALFORMED CORTEX
… an increased response to group I metabotropic glutamate receptor agonists in the region adjacent to the malformation (PMZ). In addition there was a novel response in low threshold spiking (LTS) interneurons via mGluR5 activation. To determine whether cell specific expression of these receptors …
-
Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
<p>Ionotropic glutamate receptors (iGluRs) found in mammalian brain are primarily known to mediate excitatory synaptic transmission crucial for learning and memory formation. The family of iGluRs consists of AMPA receptors, NMDA receptors and kainate receptors with each member having distinct …
-
Conformational Dynamics of the Glutamate Receptors via single Molecule Förster Resonance Energy Transfer
Glutamate receptors perform a critical role in the nervous system, mediating synaptic transmission through cellular membranes. These proteins have developed a quick response to agonist presence and, when activated, undergo a conformational shift that allows calcium ion transport across the …
-
Axon/dendrite Targeting of Metabotropic Glutamate Receptors by Their Cytoplasmic Carboxy Terminal Domains
The subcellular targeting of neurotransmitter receptors is vital in controlling polarized information flow in the brain. We show here that metabotropic glutamate receptors are differentially targeted when expressed from defective viral vectors in cultured hippocampal neurons: group I mGluR1a and …
-
Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis
… targets for antiepileptic drugs have included glutamatergic ion channels. However, interfering with excitatory signalling at these channels can alter normal neural communication and can have negative side effects, including cognitive dysfunction and fatigue, which are among the most common …
-
The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… of peripheral injury, increased ionotropic glutamate receptor mediated activity results in spinal central sensitization. Extracellular single-unit recordings from all three regions of the spinal cord (lumbar enlargement, thoracic cord, and brachial enlargement) were made on both contused and …
-
Super-resolution imaging of glutamate receptors in cultured hippocampal neurons under basal and LTP conditions
The locations and dynamics of glutamate synaptic receptors—the AMPA receptors (AMPARs) and NMDA receptors (NMDARs)—located on the postsynaptic membrane of nerve cells, are crucial for neuronal health, learning and memory formation. They can exist under basal condition where no synaptic strength …
-
cpg2 encodes a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors
… vesicles, some of which trafficked NMDA receptors, and disrupted the internalization of glutamate receptors. In addition, alterations in its protein levels affected dendritic spine size, supporting a role for CPG2 in regulating membrane trafficking. These data suggest that CPG2 organizes …
-
Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors
… in the mesocorticolimbic system related to glutamate receptors, SAPAPs, and affects drug self-administration. Taking all the previously discussed research studies into consideration, we hypothesized that low-dose cocaine self-administration would yield a significant elevation in drug seeking …
-
THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
Glutamate is the major excitatory neurotransmitter in the brain and is crucial for processes such as learning and memory. Due its importance as a signaling molecule, the extracellular glutamate concentration is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these …
-
THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
Glutamate is the major excitatory neurotransmitter in the brain and is crucial for processes such as learning and memory. Due its importance as a signaling molecule, the extracellular glutamate concentration is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these …
-
Group II Metabolic Glutamate Receptors in the Basal Amygdala Regulate Sleep and Fear-Induced Alterations in Sleep
<p>Glutamate is a major excitatory neurotransmitter in the brain and it has been recognized as playing an essential role in activating and maintaining arousal. Group II metabotropic glutamate (mGlu II) receptors are expressed in the amygdala, a brain structure important in the regulation of stress …
-
Direct neuronal and microglia-mediated effects of group I metabotropic glutamate receptors in neurodegenerative and neuroinflammatory processes
The group I of metabotropic glutamate (mGlu) receptor, mGlu1 and mGlu5 receptors are involved in neurodegenerative and in neuro-inflammatory processes. We have examined the role of mGlu5 receptor in a neuroinflammatory context. This receptor is expressed in glial cells and has been reported to play …
Page 1 of 6