Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"Glutamate Receptor"”.
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Glutamate Receptor-Mediated Taurine Release From The Hippocampus During Oxidative Stress
… also suggest that the excitatory amino acid glutamate plays an important role in both brain tissue swelling and in cell volume regulation. We examined relationships between oxidative stress, glutamate receptor activation, cell swelling, and volume regulation in acutely prepared slices of rat …
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A study of glutamate receptor function in the rat barrel cortex
Bibliography: leaves 137-156.
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Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
Metabotropic glutamate receptor 5: mGlu5) has been suggested to play a role in the development and maintenance of chronic pain. mGlu5 is expressed at synapses throughout the pain neuraxis where it is believed to modulate the function of ion channels that underlie nociceptive transduction and …
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Understanding the activation-deactivation mechanism of glutamate receptor proteins at the single molecule level
Ionotropic glutamate receptor proteins form ion channels at the neuronal membrane and mediate excitatory synaptic neurotransmission in the mammalian central nervous system. These receptor proteins, such as NMDA and AMPA receptors, are structurally diverse and house multiple extracellular and …
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INVESTIGATION OF THE STRUCTURE AND FUNCTION OF GLUTAMATE RECEPTOR GLUR2 USING SOLUTION NMR SPECTROSCOPY
Glutamate receptors are the most widespread neurotransmitter binding proteins in the vertebrate nervous system, and have been implicated in a variety of higher brain functions and pathological conditions. A better understanding of the structure and function of these receptors is highly desirable …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
… presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and nucleus accumbens (NAc), consequently facilitating drugseeking behavior. Metabotropic glutamate receptor 5 (mGluR5) has been implicated in cocaine …
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Role of Medial Prefrontal Cortical Group II Metabotropic Glutamate Receptor in the Development of Cocaine Sensitization
… prefrontal cortical (mPFC) group II metabotropic glutamate receptors (mGluR<sub>2/3</sub>) in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR<sub>2/3</sub> receptor agonist, APDC, dose-dependently reduced acute behavioral response to …
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Dopamine Transporter (DAT) and Metabotropic Glutamate Receptor 5 (MGLU5) Irreversible Probes for Identifying Anti-Psychostimulant Therapeutics
… transporter (DAT) inhibitors and metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) possess promising anti-addiction therapeutic properties. However, the lack of human DAT (hDAT) and mGlu5 X-ray crystal structures makes it difficult to understand how these promising …
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Investigating the dependency of metabotropic glutamate receptor 1 signaling for sustaining rapid proliferation of hemangiosarcoma cells
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING
Group I metabotropic glutamate receptors (mGluRs) - mGluRl and mGluR5 - are believed to contribute to neuronal death upon overstimulation and may be neuroprotective under other conditions. To develop treatment for mGluRs, we must identify proteins involved in their signalling. We have identified …
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Role of group II metabotropic glutamate receptor subtype 2 (mGluR2) in appetitive and consummatory aspects of ethanol reinforcement
<p>Background: Group II metabotropic glutamate receptors (mGluR2/3) are predominately presynaptically located G<sub>i/o</sub> coupled receptors that are highly expressed in the cortex, nucleus accumbens, amygdala, and hippocampus. Previous studies suggest that group II mGluRs are involved in …
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Metabotropic glutamate receptor 5 : a therapeutic target in Fragile X and a regulator of plasticity in visual cortex
… retardation protein (FMRP) and metabotropic glutamate receptor 5 (mGluR5) act in functional opposition to regulate local translation of synaptic mRNAs. Fragile X is the most common form of inherited intellectual disability and autism, and is expressed by a loss of FMRP. Previous studies have …
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INTERACTION BETWEEN ESTROGEN RECEPTOR AND METABOTROPIC GLUTAMATE RECEPTOR 1 MEDIATES THE DUAL EFFECT OF ESTROGEN IN NEUROPROTECTION AND NEURODEGENERATION
Estrogen receptors (ER) are known to exert important action in the central nervous system, including neuroprotection. These effects are due to interaction of estrogen with membrane localized receptors that signal through rapid transduction pathways. How membrane ERs initiate rapid signal …
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Dopamine Transporter (DAT), Nicotinic Acetylcholine Receptor (nAChR), and Metabotropic Glutamate Receptor 2 (mGlu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics
Numerous in vitro and in vivo studies implicate that certain ligands that interact with DAT, nAChRs, and mGlu2 have tremendous potential as anti-addiction therapeutics. However, understanding how these promising anti-addiction compounds interact with their major drug targets at the molecular level …
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Pre-clinical Targets for Ischemic Brain Injury
… has shown that there is extensive vesicular glutamate release during ischemia, causing excitotoxic injury to oligodendrocytes, resulting in demyelination. Glutamate receptor antagonists have been trialled in stroke patients but fall short due to adverse side effects from high dose …
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The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… of peripheral injury, increased ionotropic glutamate receptor mediated activity results in spinal central sensitization. Extracellular single-unit recordings from all three regions of the spinal cord (lumbar enlargement, thoracic cord, and brachial enlargement) were made on both contused and …
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The Effect of L-Proline on Two Recombinant AMPA Glutamate Receptors
… been shown to be a low affinity agonist at glutamate and glycine receptors. Because schizophrenia is thought to arise from glutamate receptor hypofunction and l-proline can act at glutamate receptors, it is necessary to understand whether increase in l-proline can contribute to glutamate …
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Ionic dysregulation in white matter damage
… Particular attention was paid to consequences of glutamate receptor activity. Using the oxygen glucose deprivation model of ischaemia, in the mouse brain slice, it was found that ischaemia-induced potassium release is greater in cortical grey than in corpus callosum white matter. This distinction …
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