Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Glucuronidation"”.
-
The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans
… to extensive first-pass metabolism, especially glucuronidation, which results in the large amount of glucuronide metabolites but low levels of free EL in human plasma. Hepatocytes and enterocytes express UDP-glucuronosyltransferases (UGT), the enzymes responsible for the conjugation of …
-
Relationship Between Flavonoid Structure And Phase-II Metabolism
… between UGTs and flavonoids for predicting glucuronidation of flavonoids. The goals of this research project were to: 1) identify the major UGT isoform(s) contributing to the glucuronidation of flavonoids and predicting the major organ of metabolism; 2) establish the substrate-selectivity …
-
SYNTHESIS AND CHARACTERIZATION OF RESVERATROL AND ITS CONJUGATED METABOLITES AND CONTRIBUTION OF METABOLISM TO ITS DECREASED BIOVAILABILITY
… Chapter 3 details the results of the glucuronidation kinetics of cis and trans-resveratrol isomers across a wide concentration range chosen to mimic blood levels following high dose consumption. Human tissue microsomes and recombinant supersomes over-expressing the enzymes (UGTs) of …
-
Effects of tannins on protein digestibility and detoxification activity in gray squirrels (Sciurus carolinensis)
… of tannins on digestion and detoxification (glucuronidation) activity. In the Acorn experiment, Northern red oak acorns (Quercus rubra), white oak acorns (Q. alba), or rat chow were fed to squirrels. Levels of phenols, condensed tannins, and hydrolyzable tannins were higher in red oak acorns …
-
A study of the metabolism and metabolomics of polyphenols using isolated rat hepatocytes and liquid chromatography-high resolution mass spectrometry
… sulfated but other transformations such as glucuronidation and glycine conjugation occurred. In addition, the two phenyl propanoid compounds also formed conjugates with glutathione which added across the double bond in the side chain. Quercetin underwent both metabolism and complex …
-
ROLE OF OXIDATIVE REACTIVE SPECIES AND ANTIOXIDANTS IN METABOLISM AND TRANSPORT OF THERAPEUTIC DRUGS
… of Qc and 2Me-E2 could result in decreased glucuronidation of 2Me-E2. Using the LS180 intestinal human colon adenocarcinoma cell line, glucuronidation of 2Me-E2 resulted in formation of only one major glucuronide, 2-Methoxyestradiol-3-glucuronide (2Me-E2-3G). Qc effectively reduced its …
-
Factors affecting the metabolism and toxicity of DEHP
… products, that can be excreted, involves Glucuronidation, which is catalysed by UDP- glucuronyltransferase (UDPGT) in the liver. This hepatic enzyme develops to its adult levels to a large extent after birth. Deficient UDPGT can lead to hyperbilirubinemia as it is responsible for …
-
Exploring the potential application of glucuronides as a prognostic biomarker for disease.
… from xenobiotic molecules that have been through glucuronidation. Since research have not addressed the relation of the fate of glucuronide species and diseases. It is important to clarify the concept for disease prognostics based on glucuronide species in their excretion. Therefore, the aim of …
-
Biosynthesis and function of glucuronic acid substitution patterns on softwood xylan
… insights into the process of conifer xylan glucuronidation and the possible role these branches may be playing in the maintenance of softwood recalcitrance and mechanical properties. In addition to identifying potential mutagenesis targets for improving softwood processing, this work is a …
-
Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
… was estimated as 862 mL/min, primarily due to glucuronidation. Less than 0.01 % of total administered dose of 2ME2 was excreted unchanged in urine, and about 1% was excreted as glucuronides. Plasma protein binding of 2ME2 was studied using equilibrium dialysis. Mean unbound fraction of 2ME2 …
-
Expression and activity of enzymes in the human placenta: pharmacological & toxicological consequences in AZT therapy
… after 4h of perfusion. The low levels of glucuronidation of AZT catalysed by the human placenta (approximately 2% of a dose) are not due to insufficient transport of the co-factor UDPGA and are unlikely to be significant in terms of maternal whole-body clearance. Therapeutic failure of AZT …
-
Xylan chain length and plant cell wall assembly
… more severely stunted when their xylan lacked glucuronidation. This phenomenon was not explained by compositional changes, and solid-state NMR revealed that scarce, short, and non-glucuronidated xylan had unusual hydration levels, suggesting a different cell wall arrangement. Xylan has been …
-
Modulatory effect of EVOO polyphenols and their metabolites on inflammatory response in Adenocarcinoma Colon Cells (Caco-2) and Human Umbilical Vein EC (HUVEC)
… vitro models. In particular, HT and Tyr undergo glucuronidation and sulfonation, and their sulphate and glucuronide metabolites are the prevalent forms found in human plasma and urine where they reach relevant concentrations compatible with biological activity. In this context, the aim of the …
-
Pharmacokinetics of propofol in cats
… Propofol is rapidly metabolized by hepatic glucuronidation in most species and it has also been shown to undergo extrahepatic metabolism9-13, so that total body clearance may exceed liver blood flow in certain species. Because of their highly carniverous diet, cats are little exposed to …
-
Korrelation des Polymorphismus der Uridindiphosphat-Glukuronyltransferase Isoform 1A1 mit der Glukuronidierung von Bilirubin und Paracetamol und der klinischen Diagnose des Gilbert Syndroms
In einer Population von 304 Männern und Frauen konnte die Frequenz der TA-Duplikation im Promotor der Uridin-Diphosphat-Glukuronyltransferase Isoform 1A1 bestimmt werden. Sie beträgt 0,39 in der Gruppe der Männer und 0,30 in der Gruppe der Frauen, in der Gesamtgruppe kommt das Allel mit einer …
-
Characterisation of the sulfotransferases catalysing the sulfation of xenobiotics and steroids in bovine liver
… prepared from bovine liver. It was found that glucuronidation was the main route for estradiol metabolism in cattle since large amount of glucuronide metabolites were detected in microsomes and cryopreserved hepatocytes. In comparison no sulfate metabolites were detected in cytosol and …
-
Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… to SCD pathophysiology, including xenobiotic glucuronidation (GO:0052697, p = 2.3e-03), and drug metabolism - other enzymes (p = 2.1e-02). Further analyses of the 50 genes, identified key genes in human proteinprotein networks: NTSR1, LRMDA, SMAD SMAD4 and CDH2. These four genes also …