Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Glucotoxicity"”.
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Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
… signalling pathway in both lipotoxicity and glucotoxicity. Rosiglitazone (ROZ) effectively counteracted the deleterious effects of palmitate but not that of high glucose on the islet function. Glucose-induced expression of iNOS with subsequent β-cell dysfunction was markedly counteracted by …
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The impact of glucotoxicity on pancreatic β-cell function
… main causative factors in the pathogenesis of glucotoxicity. The GPR40 protein is interactively modulated by both hyperlipidemia and hyperglycemia. Taken together, these contributing signaling factors are promising targets for pharmacotherapy in different variants of type 2 diabetes.
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Mechanisms of High Glucose-induced Decrease in β-cell Function
… can decrease β-cell function and mass (β-cell glucotoxicity); however, the mechanisms are incompletely understood. The objective was to examine the mechanisms of β-cell glucotoxicity using in vivo and ex vivo models. The hypothesis is that oxidative stress plays a causal role in high …
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Islet Dysfunction In Diabetes
… rodent and human islets strongly suggest that glucotoxicity induced pancreatic beta cell damage involves the degradation of nuclear lamins A and B, via ER stress-mediated activation of executioner caspases 3 and 6. We confirmed this by employing pharmacological approaches [inhibitors of -ER …
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Small gtp-binding proteins in insulin secretion
… of Arf6 and Rac1 in beta-cells exposed to glucotoxicity and their abnormal response to physiological concentrations of glucose. This evidence indicates that defective insulin secretion seen in progressive beta-cell failure even after normalization might be at the level of abnormal …
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Investigation of insulinotropic and cytoprotective effects of selected amphibian skin peptides
Type 2 diabetes mellitus (T2DM) accounts for over 90% of all cases of diabetes. It is characterized by persistently high blood sugar levels, insulin resistance, and ongoing pancreatic β-cell failure, primarily due to oxidative stress and lipotoxicity. Current treatments face several issues, such as …