Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Glucose transporters"”.
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Regulation of glucose transporters in sheep placenta
Transplacental glucose transport is vital to fetal growth. Although the presence of glucose transporter-1 (GLUT1) and GLUT3 has been demonstrated in mammalian placenta, the factors regulating these genes remain unclear. Therefore, the overall aim of these studies was to clone ovine GLUT1 (oGLUT1) …
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The development of a radiolabelled macromolecule as a therapeutic agent for the treatment of cancer
… and iii) induce active targeting through a glucose moiety recognised by the over-expressed glucose transporters on the surface of highly metabolically active cancer cells. The various cyclam functionalisation strategies explored were relatively unsuccessful, but eventually a bis-aminal …
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Developing and utilizing a robust mass spectrometry-based approach to study glucose metabolism and transport in the lens
… However, the delivery of energy sources such as glucose and waste removal cannot occur via the vasculature as this would obstruct the path of light through the lens. Thus, the lens requires a highly developed glucose delivery system to maintain its transparency. This thesis not only examines …
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Effects of Rosemary Extract and Rosemary Extract Polyphenols on Skeletal Muscle Insulin Resistance
… of insulin, accounts for ~80% of postprandial glucose disposal and plays a significant role in the regulation of glucose homeostasis. Insulin increases muscle glucose uptake by increasing the translocation of intracellularly stored GLUT4 glucose transporters to the plasma membrane through the …
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Regulation of Nutrient Metabolism in Equine Skeletal Muscle and Adipose Tissue
Glucose and lipid metabolism are dysregulated in obese horses. Altered glucose metabolism is evidenced by the development of insulin resistance and increased fasting plasma insulin concentrations (hyperinsulinemia) while altered lipid metabolism is evidenced by increased plasma lipid …
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Isolation and characterisation of anti-diabetic pharmacological activities of phytoestrogens and components of Moringa peregrina (Forssk) Fiori
… effect of these six extracts on the uptake of glucose in a human hepatoma cell line (HepG2) using a well-studied fluorescent derivative of glucose, 2-2-[N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino glucose (2-NBDG). The cells can take up 2-NBDG instead of glucose via glucose transporters and …
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Production, characterization and evaluation of anti-diabetes peptides from proteins of improved common bean (Phaseolus vulgaris L.) cultivars using bioinformatic tools, enzymatic systems, and in vitro and in vivo models
… potential to bind and blocking intestinal glucose transporters SGLT1 and GLUT2. Besides, using Caco-2 cells monolayer insert we observed that protein fractions reduce glucose absorption by 6.5 and 24.5 after 30 min and 24 h, respectively. It could be due to protein fractions were also able …
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The Importance of Glucose Transport in Reproductive Events
ABSTRACT OF THE DISSERTATION The Importance of Glucose Transport in Reproductive Events by Katie Lynn Adastra Doctor of Philosophy in Biology and Biomedical Sciences Developmental, Regenerative and Stem Cell Biology Washington University in St. Louis, 2012 Professor Kelle H. Moley, Chairperson …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… increase in protein synthesis with facilitated glucose transport, and was independent of the serotonin and noradrenaline reuptake inhibition produced by sibutramine. Pinitol (a methyl inositol) had an insulin mimetic effect and was an effective glucose-lowering agent in insulinopenic states, …
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Progesterone receptor targets play critical roles in maintaining pregnancy and disease prevention
… promotes expression and membrane localization of glucose transporters (GLUT), allowing for increased glucose movement into the cell to meet the metabolic demands of differentiation. This work provides insight into the metabolic shifts in differentiating stromal cells and the hormone regulated …
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Development and Applications of Opioids Alternatives for Pain Management
… The prodrug utilized facilitated transport by glucose transporters across the perineurium, eliminating the side effects typically caused by capsaicin, such as burning pain, seizures, and respiratory depression. A single injection at the sciatic nerves of rats resulted in nociceptive-selective …
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Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
The brain is the primary organ that senses blood glucose levels and initiates a stress response when blood glucose levels are too low: hypoglycemia). Insulin-dependent people with Type 1 diabetes: T1DM) have an impaired ability to sense hypoglycemia and an impaired ability to activate this …
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The Influence of Chromium Supplementation on the Insulin Pathway, Carcass Traits, and Meat Quality of Feedlot Steers
… protein S6 kinase 1 (p70S6K) abundance and glucose transporters (GLUT) 4 and 1 gene expression. Experiment 1 showed an increase in dressing percentage (DP), KPH, and shear force, but a decrease in marbling for Cr400 steers. Final BW, HCW, 12th rib backfat (BF), LMA, yield grade (YG), or …
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Regulation of Glucose Uptake and Transporter Expression in the North Pacific Spiny Dogfish (Squalus suckleyi)
… few carbohydrates and have little reliance on glucose as an oxidative fuel, the one exception being the rectal gland. This has led to a dearth of information on glucose transport and metabolism in these fish, as well as the presumption of glucose intolerance. Given their location on the …
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Interventions against obesity through increased lipolysis in adipose tissue
… M2 and mazindol were capable of increasing glucose uptake into insulin sensitive tissues. M2 and mazindol can act directly on adipose tissue and skeletal muscle to increase glucose uptake via a pathway involving new protein synthesis and activation of the glucose transporters. The …
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The role of extracellular signal-regulated kinases (ERKs) in T lymphocytes
… proteins included eukaryotic initiation factors, glucose and amino acid transporters, cytokines like IL-2, cytolytic molecules such as granzyme B, surface molecules such as CD25 and transcription factors like EGR1. These results provide a comprehensive understanding of the role of ERK1/2 in …
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Beta-Amyloid oligomeric and monomeric states: implications for Alzheimer's Disease
… endogenous Abetarelease was required to uphold glucose uptake during activation, and exogenously added Abeta monomers caused the translocation of type-3 glucose transporters to the plasma membrane with ensuing glucose uptake. We suggest that pathological aggregation of Abetamonomers, as …
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Glucose metabolism in the outer segments of photoreceptor cells : its involvement in the phototransduction process
The existence and function of glucose metabolism in the outer segments of photoreceptor cells were investigated using biochemical and immunocytochemical approaches. The presence of glycolytic enzymes in photoreceptor outer segments was detected by enzyme activity assays, Western blotting, and …
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Effects of Chronic High Sucrose With Dietary or Drinking Inclusion on the Electrogenic Glucose Absorption in the Intestinal Tract of Mice (Mus musculus)
… on the intestinal electrogenic sodium dependent glucose transport, the first portal of entry for glucose, is unknown. Here female C57bl/6 mice fed a normal standard chow diet, and 20% sucrose in the drinking water for 8 months, or 35% sucrose inclusion in the diet for 12 months were assessed. The …
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Regulation of SNARE-dependent fusion in an in vitro system
Glucose homeostasis depends on the ability of insulin to stimulate glucose uptake into both muscle and adipose tissue by promoting the translocation of glucose transporters (GLUT4) from intracellular sites to the plasma membrane (PM). In individuals with Type 2 diabetes the ability of insulin to …
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