Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Glucose sensing"”.
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The development of a minimally invasive glucose sensing system
… this research is to develop a minimally invasive glucose sensing system for diabetic patients. The device will consist of an array of micro-needles that penetrates only the stratum corneum layer of the skin and tests glucose levels in the interstitial fluid (IF). This device does not reach the …
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Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
The brain is the primary organ that senses blood glucose levels and initiates a stress response when blood glucose levels are too low: hypoglycemia). Insulin-dependent people with Type 1 diabetes: T1DM) have an impaired ability to sense hypoglycemia and an impaired ability to activate this …
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Role Of Hyperglycemia, Hypoglycemia, and Glucose Transporter 4 on Brain Glucose Sensing, Counterregulation, and Neuronal Viability
As glucose is the main fuel source for the brain and a major nutrient for peripheral tissues, the brain must sense and respond to changes in blood glucose in order to sustain its own nutritional requirements and maintain whole body energy homeostasis. Disruption of brain glucose sensing results in …
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The Role of Interleukin-6 in the Regulation of Glucose Sensing in Hypothalamic GT1-7 Neurons
… the brain plays in the regulation of whole body glucose homeostasis, including a vital role in mounting the CRR. Detection of hypoglycaemia by specialised glucose-sensing neurons of the hypothalamus is critical for initiating the associated CRR. It is believed that defective CRRs are mediated by …
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Glucosensing, Hypoglycemia, and the Brain
<p>Glucose homeostasis can be peripherally and centrally mediated. Within the periphery, GLUT4 in muscle and adipose tissue is required for normal glucose homeostasis and disruption of GLUT4 translocation in these tissues leads to glucose intolerance and insulin resistance, hallmarks of Type 2 …
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Mechanism of Insulin Release From Islets of Langerhans in a Rat Model of Normal Infants and Infants of Diabetic Mothers
… insulin hypersecretion due to the elevated glucose concentration in utero. The mechanism for the hypersecretion of insulin is not known. The glucose sensing mechanism in the fetal and neonatal IDM and normal control rats was investigated. Pregnant rats were given an i.p. injection of …
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Electrothermal controlled-exposure technology
… biowarfare agent detection and in vivo glucose sensing. Both applications employ sensing mechanisms that can be miniaturized and packaged in an array. These sensors are susceptible to fouling or degradation over time from environmental factors. The controlled-exposure technology …
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SYNTHESIS AND CHARACTERIZATION OF HIGHLY FLUORESCENT TUNABLE AZABORINE PHOTO-INDUCED ELECTRON TRANSFER GLUCOSE SENSOR
<p>The process of detecting glucose is useful in tracking and obtaining rapid results regarding the presence and amount of glucose within a biological system. Over the past decades, boronic acid derivatives such as <em>ortho</em>-aminomethyl phenylboronic acid have been utilized heavily in glucose …
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The role of central IL-6 signalling in the development of Type 2 Diabetes
… 2 diabetes results from a chronic disruption of glucose homeostasis as a consequence of environmental and genetic factors. The regulation of hypothalamic metabolic signalling is understood to be critical to the dynamic and long-term maintenance of glucose homeostasis by virtue of its influence on …
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Functionalized hydrogel systems for molecular sensing and transport
… properties for applications in molecular sensing and transport. There are two focus areas under the hydrogel theme within this dissertation. The first area is focused on the design, synthesis, and characterization of hydrogel glucose sensor materials with a liner fast response, small …
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Investigation of KATP channel function in response to metabolic and pharmacological manipulation, in the hypothalamic GT1-7 cell line
… the brain is involved in regulating whole-body glucose homeostasis, including the CRR to hypoglycaemia. The aim of the current study was to investigate if adaptations occur, following RH, which are intrinsic to glucose-sensing neurons in the absence of synaptic/glial inputs or signals from the …
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Bio-Inspired and Nanotechnology-Enabled Drug Delivery for Diabetes and Brain Cancer
… pH-responsive nanoparticles embedded within a glucose-sensing matrix to mimic the physiological delivery of insulin. To prolong implant lifetime we developed a formulation of highly concentrated insulin, up to 80 mg/mL, which maintained excellent insulin stability for up to 30 days under …
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Radioimmunoassay of insulin and glucagon with studies on the obese hyperglycaemic syndrome in mice
… were characterised by numerous abnormalities of glucose homeostasis, several of which were detected in heterozygous (ob/+) mice. Obese mice exhibited pancreatic alpha cell dysfunction and hyperglucagonaemia. Investigation of this defect revealed a marked insensitivity of an insulin dependent …
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Novel Ni-based Nanostructures: Synthesis and Application in Sensing and Energy Storage
… smart windows, electrochemical (bio)sensing, gas sensing, energy storage and water splitting. Ni(OH)2 and NiO nanostructures can be prepared by various methods. However, some of them require expensive or complex experimental setup which can not be used for large scale production. …
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Optical fibre-based minimally-invasive blood glucose monitoring system.
… can be controlled by tightly monitoring blood glucose levels. Several methods to accomplish this have been proposed over the years. In this thesis, a thorough literature and patent review revealed that blood glucose monitors (BGMs) based on amperometry are one of the most common technologies to …
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Exploring transition metal chalcogenides for bio sensing and environmental remediation
… energy storage, energy conversion, and biosensing. The state-of-the-art noble metal-based electrocatalysts have long been used in full water splitting, non-enzymatic glucose sensing, and supercapacitors. However, scarcity and high cost of noble metals restrict utilization of such …
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Metal-Organic Framework-Based Biosensors for Enzyme-Linked Assays
… performance and cost efficiency. Furthermore, glucose sensing and real-time monitoring were achieved by incorporating glucose oxidase (GOx) into PCN222(Fe), a highly stable iron-modified MOF that acts as a hydrogen peroxidase mimic. The PCN222(Fe)@GOx complex was identified as a promising …
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Bio-interfaced Nanolaminate Surface-enhanced Raman Spectroscopy Substrates
… offering backside-excitation, thereby label-free glucose sensing on a skin-phantom model. Towards reliable quantitative SERS analysis, an electronic Raman scattering (ERS) calibration method was developed. ERS from metal is omnipresent in plasmonic constructs and experiences identical hotspot …
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The Development of Novel Electrochemical Sensors Based on Innovative Materials
… performance and broaden functionality for both sensing and energy-related applications. The first part of this thesis is devoted to the development of laser-induced graphene (LIG)-based electrochemical sensors. It explores the fabrication of three-dimensional (3D) porous laser-scribed graphene …
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In silico testing of glucose controllers : methodology and sample application
… by exogenous insulin to control the plasma glucose concentration. An extracorporeal wearable artificial pancreas (AP) has been a research aim for over three decades. The research is motivated by the need to improve glucose control. Results of a major study, the Diabetes Control and …
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