Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Glucose Intolerance"”.
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FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance
… LA-rich (41:1), or ALA-rich (1:4) for 16 weeks. Glucose intolerance developed in WT mice, with no difference between diets. In HET mice, glucose intolerance was attenuated but this protection was removed by ALA rich diet. TG mice developed more glucose intolerance than WT. TG mice fed high LA …
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Functional responses of cardiac and skeletal muscle mitochondria to short-term obesity: are all obesities the same?
… versus their respective lean controls. Glucose tolerance tests were administered in lean, summer active squirrels (summer); hyperphagic obese, pre-hibernation period squirrels (prehib); and 5-week-old leptin-deficient (ob) and control (WT) C57-BL6J mice prior to sacrifice. …
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THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION
… insulin resistance leading to hyperglycemia and glucose intolerance. In order to maintain glucose tolerance in the insulin resistance state, increased insulin secretion is a requirement and it is because of inadequate islet adaptation that glucose intolerance develops in T2DM. The pathophysiology …
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Flavonol kaempferol in the regulation of glucose homeostasis in diabetes
… mice. Oral administration of kaempferol improved glucose intolerance and insulin sensitivity, and this effect was associated with increased Glut4 and AMPKa expression in muscle and adipose tissues. Consistent with our findings from the in iii vitro study in C2C12 muscle cell line, these findings …
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THE ROLE OF ALPHA OXIDATION IN LIPID METABOLISM
… C15:0 and C17:0 levels with the development of glucose intolerance. We found that the circulating C15:0 and C17:0 levels were not significantly influenced by the presence or absence of intestinal microbiota. The circulating C15:0 levels were significantly and linearly increased when the C15:0 …
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The compounding effects of obesity on the development of Intimal Hyperplasia following vascular intervention : a histopathological analysis
… of the role of obesity as well as progressive glucose intolerance and hyperinsulimaemia. Lean and obese Zucker fatty rats and Zucker diabetic fatty rat (ZDF) were subjected to balloon injury with or without stenting. The development of IH, along with the histological response to injury was …
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The epidemiology of clustered risk factors compatible with Metabolic Syndrome in Hawai‘i
… various cardiometabolic risk factors, including glucose intolerance, abdominal obesity, dyslipidemia and elevated blood pressure. Over the past two decades the world has experienced a sharp increase in the number of people with MetS. It is estimated that around 20--25 percent of the world's adult …
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Testing the metabolic sink postulate: subcutaneous adipose tissue the protective depot
… following intra-abdominal fat removal and glucose homeostasis. Peroxisome proliferator-activated receptor-γ (PPARγ; an activator of adipogenesis) knockout mice and control mice received either Sham surgery or intra-abdominal lipectomy. The inability of cell proliferation following lipectomy …
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Regulation of Glucose Uptake and Transporter Expression in the North Pacific Spiny Dogfish (Squalus suckleyi)
… few carbohydrates and have little reliance on glucose as an oxidative fuel, the one exception being the rectal gland. This has led to a dearth of information on glucose transport and metabolism in these fish, as well as the presumption of glucose intolerance. Given their location on the …
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Exploring the Importance of PREX Proteins in Glucose Homeostasis and Insulin Signalling
… the thermogenic capacity and insulin-stimulated glucose uptake in adipocytes, whereas PREX2 was reported to mediate glucose tolerance, possibly through its adaptor function as an inhibitor of the tumour suppressor PTEN. The aims of this project were to explore the importance of PREX proteins in …
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Childhood Obesity and School-Based Interventions: An Evidence-Based Best Practice Guideline
… and serious in nature. Insulin resistance, glucose intolerance, dyslipidemia, hypertension, metabolic syndromes, fatty liver disease, menstrual abnormalities, gallstones, sleep apnea, poor body image, low self esteem, and discrimination are all potential consequences of childhood obesity. …
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The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis
… tissue depots and liver weights, fed-state blood glucose and plasma insulin, intraperitoneal glucose tolerance, hepatic triacylglyceride (TG) content, plasma alanine transaminase, plasma adiponectin and monocyte chemoattractant protein-1 (MCP-1) levels, as well as the expression of genes …
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The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis
… tissue depots and liver weights, fed-state blood glucose and plasma insulin, intraperitoneal glucose tolerance, hepatic triacylglyceride (TG) content, plasma alanine transaminase, plasma adiponectin and monocyte chemoattractant protein-1 (MCP-1) levels, as well as the expression of genes …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… in driving obesity-associated inflammation and glucose intolerance. Leptin signaling has been shown to directly promote inflammatory T helper 1 (Th1) and T helper 17 (Th17) cell differentiation and function. Since T cells have a critical role in driving inflammation and systemic glucose …
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Role of Ceramide Accumulation in the Ventromedial Hypothalamus in Driving Systemic Metabolic Impairments During Obesity
… in this brain region vital to the control of glucose homeostasis and body weight. We found that ceramide accumulation in the VMH during obesity drives glucose intolerance without changing body weight or insulin sensitivity, and that this effect is due to an increase in glucagon sensitivity. …
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Distinct Functional Properties of Perinatal Versus Adult Adipose Progenitor Subpopulations
… protection against pathologic wat remodeling and glucose intolerance in adult-onset obesity. Thus, factors that alter the adipogenic capacity of perinatal adipose progenitors can have long-lasting effects on progenitor plasticity, tissue expandability, and metabolic health into adulthood.
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Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease
… with ischaemic heart disease and either glucose intolerance or type 2 diabetes. Paper III showed that a Paleolithic diet improved glucose tolerance more than a Mediterranean-like diet, and paper IV showed that a Paleolithic diet was more satiating per calorie than a Mediterranean-like …
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Glucosensing, Hypoglycemia, and the Brain
<p>Glucose homeostasis can be peripherally and centrally mediated. Within the periphery, GLUT4 in muscle and adipose tissue is required for normal glucose homeostasis and disruption of GLUT4 translocation in these tissues leads to glucose intolerance and insulin resistance, hallmarks of Type 2 …
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Adiponectin deficiency leads to hepatic steatosis and contributes to the development of gestational diabetes mellitus
… characterized by hyperglycemia and impaired glucose tolerance with first onset mid-gestation. Genetic predisposition, maternal obesity and diet contribute to development of GDM. In addition, low levels of serum adiponectin are associated with increased risk for GDM. Adiponectin is an adipose …
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Neuropeptide FF and Neuropeptide VF and their control in the regulation of energy homeostasis and glucose metabolism
… (NPVF) in the regulation of energy balance and glucose homeostasis. This study reveals that NPFF signalling plays important roles in fluid and glucose homeostasis, since Npff-/- mice exhibit an increased water intake and improved glucose tolerance, the latter being due to higher insulin …
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