Global ETD Search
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Showing 1 to 7 of 7 for “"Glucolipotoxicity"”.
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Mitochondrial Involvement in Pancreatic Beta Cell Glucolipotoxicity
… failure. The molecular mechanisms of this β-cell glucolipotoxicity are yet to be established conclusively. In this thesis by exploring mitochondrial energy metabolism in INS-1E insulinoma cells and isolated pancreatic islets, a role of mitochondria in pancreatic β-cell glucolipotoxicity is …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
Prolonged exposure of pancreatic beta cells to excessive levels of glucose and fatty acids is postulated to contribute to beta cell dysfunction and beta cell death in type 2 diabetes. Nicotinamide, via its major metabolite NAD+, is involved in a wide range of biological processes, including the …
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Stress-inducible Mig6 promotes pancreatic beta cell destruction in the pathogenesis of diabetes
… assaults (e.g., endoplasmic reticulum stress, glucolipotoxicity, and pro-inflammatory cytokines) attenuate the activation of beta cell pro-survival signaling pathways via a stress-inducible molecule called Mitogen-inducible gene 6 (Mig6). We discovered that the overabundance of Mig6 exacerbates …
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Advancing Dynamic Imaging for Microfluidic Stimulated Tissues: Biology, Techniques, and Applications
… with a mixed nutrient condition associated with glucolipotoxicity. This observation suggests a glucose-mediated shift in lipid partitioning away from fatty acid oxidation. Furthermore, we found that excess branched-chain amino acid leucine prematurely turns off fatty acid oxidation despite the …
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Studies on the mechanism of insulin signaling reduction in high glucose/palmitate-induced INS-1 beta cell death
… 정의 1 2. 당뇨병 발병 원인과 베타세포 양적 조절 1 3. 포도당/지방산 독성 (Glucolipotoxicity) 2 B. 고농도 포도당과 지방산이 INS-1 베타세포에 미치는 영향 2 1. 대사관점 2 2. 유전자 발현 2 3. 신호 전달 3 C. 고농도 포도당과 지방산에 의한 IRS-1 tyrosine 기 감소의 원인 4 1. IR (insulin receptor) 에 의한 IRS-1 tyrosine기 인산화 감소 4 2. IRS-1 Serine 인산화가 증가시킴으로 인해 IRS-1 tyrosine 인산화 를 감소 5 …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… triglyceride accumulation, was termed beta cell glucolipotoxicity. The cellular mechanisms involved in FFA-induced beta cell apoptosis are not fully understood. FFAs are usually non-toxic to beta cells if they are oxidized. However, the accumulation of long chain acyl-CoAs or lipid derivatives, …
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Einfluss von Glucolipotoxizität auf die Funktion der β-Zellen diabetessuszeptibler und –resistenter Mausstämme
Ziel der vorliegenden Arbeit war es, die Auswirkungen von Glucose- und Lipidtoxizität auf die Funktion der β-Zellen von Langerhans-Inseln in einem diabetesresistenten (B6.V-Lepob/ob, ob/ob) sowie diabetessuszeptiblen (New Zealand Obese, NZO) Mausmodell zu untersuchen. Es sollten molekulare …