Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Glucocorticoid Resistance"”.
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Glucocorticoid resistance in COPD patients and lung cancer
… surrounding microenvironment in the lung tissue. Glucocorticoids are the main treatment for many inflammatory diseases, however, the majority of COPD patients are resistant to glucocorticoids, so a better understanding of the exact mechanism of glucocorticoid resistance in COPD patients and lung …
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Integrated Multimodal Genomic Analyses Reveal Novel Mechanisms of Glucocorticoid Resistance in Acute Lymphoblastic Leukemia
… affect patients both acutely and chronically. Glucocorticoids (GCs) are essential components of modern chemotherapeutic intervention for ALL. Resistance to glucocorticoids is an important factor in determining early treatment response and overall patient survival. Reduction of glucocorticoid …
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Analysis of drug resistance and the role of the stem cell niche in leukaemia
Glucocorticoids and etoposide are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoblasts through the glucocorticoid receptor (GR) and p53. However, glucocorticoid resistance, cell death mechanisms and the contribution of the bone marrow microenvironment to drug …
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Electronic Cigarette Exposure: Inflammatory and Immunological Implications in Structural Lung Cells and the Potential Public Health Consequences
… response induced by dual exposure was glucocorticoid resistant. Glucocorticoid resistance is one of the hallmarks of COPD, and thought to contribute to uncontrolled inflammation in pre-COPD (symptomatic smokers) so dual use should be avoided. Importantly, this thesis elucidates …
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Effects of Psychological Stress on Glucocorticoid Sensitivity of Inflammatory Response to Influenza Vaccine Challenge in Healthy Military College Students
… suggests that chronic stress impairs immune cell glucocorticoid sensitivity (GCS), leading to excessive production of proinflammatory cytokines. This pathway may contribute to impaired immune responses to vaccination and increased risk of infectious illness in military personnel in high stress …