Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Glucagon-like peptide 1 receptor"”.
-
The binding and activation of the glucagon-like peptide-1 receptor by exendin-4
… (EX4) has the same physiological properties as glucagon-like peptide-1 (7-36)amide (GLP-1). EX4 has 50% identity with GLP-1, with an extra nine amino acids at its C-terminus. The two peptides mediate their functions through coupling to the glucagon like peptide-1 receptor (GLP-1R) with similar …
-
VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
… insulin secretion, increases in post-prandial glucagon-like peptide-1 (GLP-1) secretion, changes in the bile acid pool/profile, and remission of hypertension. Utilizing this model we have investigated the role of β-cell glucagon-like peptide-1 receptor (GLP-1R) signaling in the glucoregulatory …
-
Association of GLP-1 Receptor Agonist Use with Kidney and Cardiovascular Outcomes in Stable Kidney Transplant Recipients
Recent surges in the use of glucagon-like peptide-1 receptor agonists (GLP-1RA) have shown promise in reducing cardiovascular events and improving kidney function in patients with type 2 diabetes. Due to these hopeful improvements, kidney transplant recipients (KTRs) have started using GLP-1RA. …
-
GLP1R IS A T CELL NEGATIVE COSTIMULATORY MOLECULE
Glucagon Like Peptide-1 Receptor (GLP1R) is a key regulator of glucose metabolism, known to be expressed by pancreatic β-cells, gastric mucosa and hypothalamic appetite center. Recently, GLP1R mRNA has been detected on T lymphocytes; however, its function in these cells remains poorly understood. …
-
Understanding Patient Perceptions and Behavioral Intentions Toward GLP-1 Receptor Agonists for Weight Management in the United States: A Health Belief Model Approach
<p>Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for weight management in the United States; however, limited evidence exists regarding the perceptual and behavioral factors influencing medication adherence among adult users. Prior research has largely …
-
Effect of Semaglutide on Vascular Regenerative Cells in People at Elevated Risk for Atherosclerosis
… Cardiovascular outcome trials demonstrated that glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment can reduce major adverse cardiovascular events (MACE) in people with type 2 diabetes (T2D) and/or obesity. However, the mechanisms of vascular benefit remain unknown. In particular, the …
-
Deciphering the mechanism of foxa2 inactivation by respiratory pathogens in chronically diseased lungs
… are strong agonists of FOXA2, by activating the glucagon-like peptide-1 receptor (GLP-1R)-mediated signaling that normalizes mucin expression and improved the clearance of P. aeruginosa. In summary restoration of FOXA2 function inactivated by bacterial and fungal pathogens with incretin mimetics …
-
Physiological, Morphological and molecular biological studies of the effect of Glucagon-like peptide-1 and exenatide in the diabetic rat pancreas
… effects of incretins, substances such as glucagon-like peptide-1 (GLP-1) and its synthetic agonist, exenatide on the diabetic rat pancreas compared to healthy, agematched controls. These incretins exert their beneficial effects by repairing the pancreatic islets. Thus, increasing …
-
Activation mechanisms of non-class A G protein-coupled receptors
G protein-coupled receptors are central to mediating homeostasis across a plethora of biochemical signaling pathways across the entire body and are one of the most important classes of drug targets. While the majority of the recent literature on GPCRs focuses on Class A GPCRs, the structural and …
-
Arc expression in the parabrachial nucleus following taste stimulation
… neurons is the parabrachial nucleus (PbN) and, like Arc, the PbN plays an important role in conditioned taste aversion learning. The aim of this thesis is to investigate Arc expression in the PbN following taste stimulation to elucidate the molecular identity and function of Arc expressing, …
-
A peptidomic investigation into enteroendocrine cells and islets of humans and mice
… content of the blood and responding by secreting peptide hormones to control various physiological functions. This thesis focuses on characterising the peptidome of EECs and islets by utilising liquid-chromatography coupled to mass spectrometry (LC-MS). Due to their ability to control food intake …
-
Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
… by the hormonal imbalance of insulin and glucagon, leading to dysfunctional glucose homeostasis. Glucagon-like peptide 1 (GLP-1), which is an incretin hormone, activates the predominantly Gαs-coupled glucagon-like peptide 1 receptor (GLP-1R), which is a class B G protein-coupled receptor …
-
Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
Class B1 G Protein-Coupled Receptors (GPCRs) are a small family within the GPCR superfamily. However, they are implicated in the pathologies of some of the most prevalent diseases, such as type 2 diabetes and heart disease. Despite being such a small family, their signalling is very diverse; each …