Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"Glucagon-like peptide"”.
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Circadian Secretion of Glucagon-like Peptide-1
… metabolic homeostasis. The incretin hormone glucagon-like peptide-1 (GLP-1) enhances glucose-stimulated insulin secretion following nutrient ingestion and has recently been shown to follow a circadian rhythm of secretion that parallels the expression of the core clock gene, Bmal1. However, …
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Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms
$\textbf{Background}$ Glucagon-like Peptide 1 (GLP-1) is a human incretin hormone that has been demonstrated to protect against non-lethal ischaemia reperfusion injury in the left ventricle in humans. It has been suggested from some animal research that this protection may be mediated through the …
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Self-assembly and aggregation of glucagon-like peptide 1 and its analogues
Aggregation and physical instability of peptide-based drugs poses a great challenge to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a hormone that is used in the treatment of type-2 diabetes. However, GLP-1 has a short half-life *in vivo* and it is prone to aggregate which …
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The binding and activation of the glucagon-like peptide-1 receptor by exendin-4
… (EX4) has the same physiological properties as glucagon-like peptide-1 (7-36)amide (GLP-1). EX4 has 50% identity with GLP-1, with an extra nine amino acids at its C-terminus. The two peptides mediate their functions through coupling to the glucagon like peptide-1 receptor (GLP-1R) with similar …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… at minimizing the need for TPN are necessary. Glucagon-like peptide-2 (GLP-2) may be a therapeutic agent as it reduces TPN associated atrophy and increases enzyme and transporter activity. To examine this, we coinfused GLP-2 with TPN and found increased ileal mRNA and protein abundance of the …
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Exploring glucagon-like peptide 1-secreting L-cells as signal transducers in the microbiota-gut-brain signalling pathways
Background: Communication across the microbiota-gut-brain axis is integral to homeostatic functions throughout the body. However, the mechanisms behind this communication network have yet to be fully elucidated. There is mounting evidence that bacterially secreted metabolites, such as short-chain …
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VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
… insulin secretion, increases in post-prandial glucagon-like peptide-1 (GLP-1) secretion, changes in the bile acid pool/profile, and remission of hypertension. Utilizing this model we have investigated the role of β-cell glucagon-like peptide-1 receptor (GLP-1R) signaling in the glucoregulatory …
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Physiological, Morphological and molecular biological studies of the effect of Glucagon-like peptide-1 and exenatide in the diabetic rat pancreas
… effects of incretins, substances such as glucagon-like peptide-1 (GLP-1) and its synthetic agonist, exenatide on the diabetic rat pancreas compared to healthy, agematched controls. These incretins exert their beneficial effects by repairing the pancreatic islets. Thus, increasing …
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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells
… of Alzheimer's disease (AD), amyloid beta (Aβ)- peptides, are generated by sequential proteolysis of the amyloid precursor protein (APP) by β- and γ-secretase activities. Alternatively, APP can be processed nonamyloidogenically by an α-secretase activity that cleaves within the Aβ-domain, …
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Influences of milk intake and dietary inclusion of a bioactive extract from the olive (Olea europaea) on glucagon-like peptide-2 and its effects on growth and intestinal health of dairy calves
… integrity is associated with an intestinal peptide, glucagon-like peptide-2 (GLP-2), which stimulates proliferation, decreases apoptosis, enhances intestinal barrier function, and decreases intestinal inflammation. During diarrheic episodes and at weaning, feed intake is reduced, potentially …
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Peptide Corrination for the Mitigation of Nausea and Emesis in the Treatment of Type 2 Diabetes
… B12 (B12) or other corrin constructs, of GLP glucagon-like peptide-one (GLP-1) receptor (GLP-1R) agonists or via the use of GRASP a growth differentiation factor 15 (GDF15) glial derived neurotropic family receptor α-like (GFRAL) complex antagonist.</p>
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The Path to an Orally Administered Protein Therapeutic for the Treatment of Diabetes Mellitus
<p>Protein therapeutics like insulin and glucagon-like peptide-1 analogues are currently used as injectable medications for the treatment of diabetes mellitus. An orally administered protein therapeutic is predicted to increase patient adherence to medication and bring a patient closer to metabolic …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… distal ileum and colon which expresses the proglucagon gene. Proglucagon encodes a number of important hormones, namely glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin and thus may impact intestinal development and dysfunction, type 2 diabetes, and …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… distal ileum and colon which expresses the proglucagon gene. Proglucagon encodes a number of important hormones, namely glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin and thus may impact intestinal development and dysfunction, type 2 diabetes, and …
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Generation and use of new tools for the characterisation of gut hormone receptors
… has been on the receptors of the gut hormones glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2). In recent years there has been a surge of interest in the enteroendocrine hormones particularly due to the success of GLP-1 …
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Hormone Responses to Two Different Energy Restriction Programs
There is a general decrease in satiety hormones (glucagon-like peptide 1 (GLP-1) and leptin) and an increase in hunger hormones (ghrelin) with weight loss, however results are conflicting. Currently, no studies have examined hormone levels comparing different approaches in calorie reductions for …
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Exendin 4 Conjugation and Sequence Modification to Treat Type 2 Diabetes and Obesity
… B12 conjugation to Ex-4 have on agonism of the glucagon-like peptide-1</p> <p>receptor (GLP-1R) in vitro and on PD/PK (including brain uptake and function) in vivo?</p> <p>Goal: To remove side-effects (nausea, weight loss) of Ex-4 without loss of glucoregulation.</p> <p>Q2. (Chapter 3) Can B12 …
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Association of GLP-1 Receptor Agonist Use with Kidney and Cardiovascular Outcomes in Stable Kidney Transplant Recipients
Recent surges in the use of glucagon-like peptide-1 receptor agonists (GLP-1RA) have shown promise in reducing cardiovascular events and improving kidney function in patients with type 2 diabetes. Due to these hopeful improvements, kidney transplant recipients (KTRs) have started using GLP-1RA. …
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