Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"Glucagon-Like Peptide-1"”.
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Circadian Secretion of Glucagon-like Peptide-1
… metabolic homeostasis. The incretin hormone glucagon-like peptide-1 (GLP-1) enhances glucose-stimulated insulin secretion following nutrient ingestion and has recently been shown to follow a circadian rhythm of secretion that parallels the expression of the core clock gene, Bmal1. However, …
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Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms
$\textbf{Background}$ Glucagon-like Peptide 1 (GLP-1) is a human incretin hormone that has been demonstrated to protect against non-lethal ischaemia reperfusion injury in the left ventricle in humans. It has been suggested from some animal research that this protection may be mediated through the …
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Self-assembly and aggregation of glucagon-like peptide 1 and its analogues
Aggregation and physical instability of peptide-based drugs poses a great challenge to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a hormone that is used in the treatment of type-2 diabetes. However, GLP-1 has a short half-life *in vivo* and it is prone to aggregate which …
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The binding and activation of the glucagon-like peptide-1 receptor by exendin-4
… (EX4) has the same physiological properties as glucagon-like peptide-1 (7-36)amide (GLP-1). EX4 has 50% identity with GLP-1, with an extra nine amino acids at its C-terminus. The two peptides mediate their functions through coupling to the glucagon like peptide-1 receptor (GLP-1R) with similar …
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Exploring glucagon-like peptide 1-secreting L-cells as signal transducers in the microbiota-gut-brain signalling pathways
Background: Communication across the microbiota-gut-brain axis is integral to homeostatic functions throughout the body. However, the mechanisms behind this communication network have yet to be fully elucidated. There is mounting evidence that bacterially secreted metabolites, such as short-chain …
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VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
… insulin secretion, increases in post-prandial glucagon-like peptide-1 (GLP-1) secretion, changes in the bile acid pool/profile, and remission of hypertension. Utilizing this model we have investigated the role of β-cell glucagon-like peptide-1 receptor (GLP-1R) signaling in the glucoregulatory …
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Physiological, Morphological and molecular biological studies of the effect of Glucagon-like peptide-1 and exenatide in the diabetic rat pancreas
… effects of incretins, substances such as glucagon-like peptide-1 (GLP-1) and its synthetic agonist, exenatide on the diabetic rat pancreas compared to healthy, agematched controls. These incretins exert their beneficial effects by repairing the pancreatic islets. Thus, increasing …
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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells
… of Alzheimer's disease (AD), amyloid beta (Aβ)- peptides, are generated by sequential proteolysis of the amyloid precursor protein (APP) by β- and γ-secretase activities. Alternatively, APP can be processed nonamyloidogenically by an α-secretase activity that cleaves within the Aβ-domain, …
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The Path to an Orally Administered Protein Therapeutic for the Treatment of Diabetes Mellitus
<p>Protein therapeutics like insulin and glucagon-like peptide-1 analogues are currently used as injectable medications for the treatment of diabetes mellitus. An orally administered protein therapeutic is predicted to increase patient adherence to medication and bring a patient closer to metabolic …
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Hormone Responses to Two Different Energy Restriction Programs
There is a general decrease in satiety hormones (glucagon-like peptide 1 (GLP-1) and leptin) and an increase in hunger hormones (ghrelin) with weight loss, however results are conflicting. Currently, no studies have examined hormone levels comparing different approaches in calorie reductions for …
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Exendin 4 Conjugation and Sequence Modification to Treat Type 2 Diabetes and Obesity
… B12 conjugation to Ex-4 have on agonism of the glucagon-like peptide-1</p> <p>receptor (GLP-1R) in vitro and on PD/PK (including brain uptake and function) in vivo?</p> <p>Goal: To remove side-effects (nausea, weight loss) of Ex-4 without loss of glucoregulation.</p> <p>Q2. (Chapter 3) Can B12 …
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Association of GLP-1 Receptor Agonist Use with Kidney and Cardiovascular Outcomes in Stable Kidney Transplant Recipients
Recent surges in the use of glucagon-like peptide-1 receptor agonists (GLP-1RA) have shown promise in reducing cardiovascular events and improving kidney function in patients with type 2 diabetes. Due to these hopeful improvements, kidney transplant recipients (KTRs) have started using GLP-1RA. …
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
… by the hormonal imbalance of insulin and glucagon, leading to dysfunctional glucose homeostasis. Glucagon-like peptide 1 (GLP-1), which is an incretin hormone, activates the predominantly Gαs-coupled glucagon-like peptide 1 receptor (GLP-1R), which is a class B G protein-coupled receptor …
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Cardiovascular Effects of GLP-1 and Glucagon Dual Receptor Agonism in Humans
… including dipeptidyl peptidase IV inhibitors, glucagon like peptide-1 (GLP-1) receptor agonists and selective sodium-glucose transporter-2 inhibitors (SGLT2i). These medications have transformed treatment pathways and prognosis for individuals with T2DM as well as obesity (GLP-1 receptor …
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GLP1R IS A T CELL NEGATIVE COSTIMULATORY MOLECULE
Glucagon Like Peptide-1 Receptor (GLP1R) is a key regulator of glucose metabolism, known to be expressed by pancreatic β-cells, gastric mucosa and hypothalamic appetite center. Recently, GLP1R mRNA has been detected on T lymphocytes; however, its function in these cells remains poorly understood. …
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The individual and combined effects of whey protein and acute aerobic exercise on glycemic control
… on plasma glucose, insulin, gastric inhibitory peptide (GIP), glucagon like peptide 1 (GLP-1), and glucagon in normal, healthy men. Eleven males (mean ± SD age: 24.3 ± 5.4 years; BMI: 26.0 ± 5.3 kg/m2; HbA1c: 5.2 ± 0.2 %; VO2 max: 38.3 ± 6.1 ml/kg/min) completed four randomized trials consisting …
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The Cardiovascular Effect of GLP-1 in Humans
The incretin glucagon-like peptide-1 (GLP-1) abolishes post-ischemic left ventricular contractility (stunning) in humans but the mechanism remains elusive. I hypothesized that this effect is mediated by peripheral or coronary vasodilatation. A comprehensive assessment of the haemodynamic effects of …
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Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9-39) in a normoglycemic mouse model
… Studies have shown that some flavanols increase glucagon-like peptide 1 (GLP- 1) levels. GLP-1 is a feeding hormone that increases insulin secretion after carbohydrate consumption and increased GLP-1 levels may be responsible for some of the beneficial effects on glycemic control after flavanol …
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Controlled release of GLP-1 from affinity-based protein microspheres and quantitative analysis of the role of fiber length on phagocytosis and inflammatory response by macrophages
Peptide drugs are highly specific and efficacious; interest in them remains high despite the challenges of rapid clearance and degradation. To overcome these limitations peptide delivery systems must prolong release while protecting biological activity. Glucagon-like peptide 1 (GLP-1) stimulates …
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