Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"GluR1"”.
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The Effect of L-Proline on Two Recombinant AMPA Glutamate Receptors
… at two recombinant AMPA receptors: homomeric GluR1 and heteromeric GluR1/2. Dose response to l-proline (concentrations of 3 µM – 10 mM) at homomeric GluR1 and heteromeric GluR1/2 receptors were determined and compared to saturating concentration of glutamate (10 mM). The effect of tonically …
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Die Bedeutung der Proteine 4.1G und 4.1N für den Aufbau und die Funktion glutamaterger Synapsen
… der AMPA-Rezeptor-Untereinheiten GluR1 und GluR4 identifiziert wurden. Aufgrund ihrer charakteristischen Proteinstruktur wird vermutet, dass die Proteine 4.1G und 4.1N eine entscheidende Bedeutung für den Transport von GluR1 und GluR4 an die postsynaptische Membran und somit für …
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Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder
… components NMDAR subunit 2A, AMPA subunit GluR1, beta-actin, and morphological characteristics such as primary dendrite length and cell soma size of pyramidal neurons in the hippocampus. I found that PGE2 exposure decreased LTP in males and I/O responses in females at higher stimulation …
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Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations
… acid (AMPA) glutamate receptor subunit 1 (GluR1), and a signaling system associated with these receptors (i.e., the mitogen-activated protein kinase extracellular-signal regulated kinase; ERK) in the cortical-limbic regions--may modulate the acquisition and expression of cocaine-environment …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… (AMPAR)-mediated current and synaptosomal AMPAR GluR1 subunit trafficking in the BLA; while during the late stage (24h after fear acquisition), we detected a combination of enhanced AMPAR- and NMDAR-mediated currents, increased synaptosomal NMDAR NR2B subunit expression, and phosphorylation of …
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Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton
… of synaptic NMDAR1 clusters and the number of GluR1-labeled spines. On GABAergic neurons, GluR1 clusters redistributed to non-synaptic sites, whereas on pyramidal neurons the clusters appeared to disperse. Furthermore, in control neurons AMPA receptors were extractable from pyramidal cell …
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Functional Characterization of Hippocampal Synapses in a Mouse Mutant of the Dystrobrevin Binding Protein 1 (DTNBP 1) Gene
… of surface/intracellular expression for the GluR1 and GluR4 subunits, nor changes in GluR1S845, which is associated with GluR1 surface expression, were observed in hippocampal preparations. Enhanced single channel conductance in the AMPA receptor did not appear to contribute to the increase …
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MOLECULAR FACTORS THAT INFLUENCE THE BINDING OF AGONISTS TO AMPA RECEPTORS
… the homologous lysine (K445) in AMPA-R subunit GluR1 plus 12 additional residues around the glutamate binding pocket with the expectation that this would reduce nucleotide binding even further. Nucleotide affinity was determined by measuring the displacement of [3H]fluorowillardiine. As …
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Einfluss funktionsloser Photorezeptoren auf die Anatomie der Retina - Eine licht- und elektronenmikroskopische Studie anhand der CNGA3-/-Rho-/- Maus
… und postsynaptische Glutamatrezeptoren (GluR1, mGluR6) an den Photorezeptorterminalien nachgewiesen werden. Dies lässt die Vermutung zu, dass eine Transmitterfreisetzung theoretisch möglich wäre. Darüber hinaus konnte im Zeitraum von 12 Monaten keine nennenswerte Auswirkung auf die IPL …
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Untersuchungen über die funktionelle Rolle des Neurotrophinrezeptors p75NTR
… dass zudem GluR2 wie auch GluR3, jedoch nicht GluR1 und GluR4, in vivo im p75NTR-Knockout im Vergleich zum Wildtyp in ihrer Expression signifikant verändert sind. Diese Befunde legen eine veränderte Stöchiometrie des AMPA-Rezeptors im p75NTR-Knockout nahe und liefern einen Erklärungsansatz für …
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The effects of licorice root components on cognition
… protein expression of these genes: PSD-95, GluR1, and GluR2. ISL, LRE, LRP and estradiol failed to modulate levels of those proteins. These findings suggest that ISL and LRE may, like other estrogens, enhance performance on some hippocampus-sensitive tasks in young-adult OVX rats, while …
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Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression
… of surface α1 in the cortex, and increases in GluR1 in the hippocampus after zolpidem and diazepam treatment. Study 3 measured the same measures as in Study 1 due to 30 days of i.p. injections of diazepam and zolpidem compared to vehicle. It was expected that both groups would become tolerant …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… including phosphorylation of the AMPA GluR1 receptor subunit at serine 845 in striatal and amygdala subregions, and the NMDA NR1 receptor subunit at serine 897 in the CA1 subregion of hippocampus. Tolerance also developed to cAMP-independent GluR1S831 phosphorylation in the prefrontal …
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Structural and Functional Effect of Phosphorylation On Ampa Receptors
<h1>Structural and Functional Effect of Phosphorylation on AMPA Receptors</h1> <p>Cailtin Edmunds show you, BA</p> <p>Advisory Professor: Vasanthi Jayaraman, Ph. D.</p> <p>The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is the primary contributor to neuronal fast excitatory …