Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"GluN2B"”.
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Probing spatial and subunit-dependent signalling by the NMDA receptor
… GluN2 subunits in the forebrain, GluN2A and GluN2B, has been advanced significantly by selective GluN2B antagonism yet a reciprocal GluN2A selective antagonist has been lacking. Utilizing novel GluN2A-specific antagonists, I demonstrate a developmental upregulation of GluN2A-mediated NMDA …
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Leptin induces a novel form of long-term potentiation at the direct cortical input to hippocampal CA1 synapses
… of synaptic transmission that depends on GluN2B subunit-containing NMDA receptors in juvenile hippocampus, whereas leptin evokes long-term potentiation that depends on GluN2A subunit-containing NMDA receptors in the adult hippocampus. Moreover, NMDA receptor subunits are heterogeneously …
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
… triheteromeric subunit arrangement of GluN1 plus GluN2B and/or GluN2D. Wild type (WT) mice, and those lacking the gene for GluN2D (Grin2D-null), were used to explore its role in various aspects of DA neuronal function and dysfunction using patch-clamp electrophysiology, viability assaying, and …
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The medial prefrontal cortex and the dorsomedial striatum are necessary for working memory in rats: role of NMDA receptors
… both tasks. Given the contribution of cortical GluN2B-containing NMDA receptors to working memory in primates, we tested the role of these receptors in the TUNL task and OST. Systemic injections of the GluN2B-containing NMDA receptor antagonist Ro 25-6981 impaired OST but not TUNL accuracy. …
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Pharmacology of a novel biased allosteric modulator for NMDA receptors
… modulates NMDA diheteromeric receptors (GluN2A, GluN2B, GuN2C, and GluN2C) based on (three) different glutamate concentrations. Electrophysiological recordings carried out on recombinant NMDA receptors expressed in xenopus oocytes revealed that 30μM and 100μM of CNS4 potentiated ionic currents …
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CHARACTERIZATION OF FRONTAL CORTICAL CIRCGRIN2B_011731 IN OPIOID-INDUCED NEUROADAPATIONS
… the regulatory subunit of the NMDA receptor, GluN2b, a protein essential for opioid learning and memory paradigms. First, using a custom small-interfering RNA (siRNA) targeting the backsplice junction of circGrin2b, we show that knock-down of orbitofrontal cortex (OFC) circGrin2b significantly …
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Functional consequences of mutations in GRIN2A and GRIN2B associated with mental disorders
GRIN2A and GRIN2B encode the GluN2A and GluN2B subunits of the NMDA receptor, a subtype of ionotropic glutamate receptor that displays voltage-dependent block by Mg2+ and a high permeability to Ca2+. These receptors play important roles in synaptogenesis, synaptic transmission and synaptic …
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Novel roles of striatal enriched protein phosphatase (STEP) in neuronal intrinsic properties and homeostatic synaptic plasticity
… (AMPARs) via dephosphorylating Tyr1472 of GluN2B subunit in NMDAR and 3 Tyr (Tyr869, Tyr873, and Tyr876) of GluA2 subunit in AMPAR. Despite extensive studies on the role of STEP61 in activity-dependent synaptic plasticity, including long-term synaptic potentiation and depression, it was …
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Cannabinoid regulation of excitatory synaptic transmission at hippocampal synapses
… presynaptically, and involves activation of GluN2B-containing NMDARs and stimulation of a PKA-dependent signalling pathway. We also reveal that the non-euphoric phytocannabinoid, cannabidiol (CBD), induces LTP at juvenile TA-CA1 synapses. In a manner similar to CB1R-mediated LTP, CBD-induced …
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Super-resolution imaging of glutamate receptors in cultured hippocampal neurons under basal and LTP conditions
… population of the two NMDAR subunits (GluN2A and GluN2B) are found to be very different. This ratio is known to be significant in neuronal function/dysfunction. We also quantified this ratio during the maturation process and find redistribution of the synaptic/extrasynaptic NMDARs. Next, cLTP is …