Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"GluN2A"”.
-
Probing spatial and subunit-dependent signalling by the NMDA receptor
… the two major GluN2 subunits in the forebrain, GluN2A and GluN2B, has been advanced significantly by selective GluN2B antagonism yet a reciprocal GluN2A selective antagonist has been lacking. Utilizing novel GluN2A-specific antagonists, I demonstrate a developmental upregulation of …
-
RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
… forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation (LTP) induction and NMDAR-dependent hippocampal behaviors, such as spatial learning. Under physiological conditions, Rph3A is present in approximately 50% of …
-
Functional consequences of mutations in GRIN2A and GRIN2B associated with mental disorders
GRIN2A and GRIN2B encode the GluN2A and GluN2B subunits of the NMDA receptor, a subtype of ionotropic glutamate receptor that displays voltage-dependent block by Mg2+ and a high permeability to Ca2+. These receptors play important roles in synaptogenesis, synaptic transmission and synaptic …
-
miR-125b toggles dynamics and structure of dendritic filopodia in developing hippocampal neurons
… dendritic expression and localization of the GluN2A subunit of the NMDA receptor, and we show that dendritic GluN2A is correlated with maintaining filopodial morphology. Using Spatial Light Interference Microscopy (SLIM), we show that miR-125b function contributes to maintaining the dynamicity …
-
Impact of environmental and genetic factors on pain sensitivity and chronic pain development
… mutation of the GRIN2A gene, encoding the GluN2A NMDA receptor subunit, has been identified. Here a novel Grin2A rat model was used to investigate genetic impact on sensitivity and inflammatory pain development. Sensitivity was not altered in the heterozygous Grin2A-/+ model of epilepsy …
-
Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
… the gating mechanism of PS modulation of GluN1/GluN2A receptors transiently expressed in HEK 293 cells using whole-cell and single-channel electrophysiology. Only a modest effect on the whole-cell responses was observed by PS in dialyzed (non-perforated) whole-cell recordings. Interestingly, in …
-
Conformational Changes In The Extracellular Domain of Glutamate Receptors
… and function. NMDA receptor subtypes GluN1 and GluN2A were modified such that fluorophores could be introduced at specific sites to determine their pattern of assembly. The results indicated that the GluN1 subunits assembled across each other in a diagonal manner to form a functional receptor. …
-
Pharmacology of a novel biased allosteric modulator for NMDA receptors
… modulates NMDA diheteromeric receptors (GluN2A, GluN2B, GuN2C, and GluN2C) based on (three) different glutamate concentrations. Electrophysiological recordings carried out on recombinant NMDA receptors expressed in xenopus oocytes revealed that 30μM and 100μM of CNS4 potentiated ionic …
-
Leptin induces a novel form of long-term potentiation at the direct cortical input to hippocampal CA1 synapses
… evokes long-term potentiation that depends on GluN2A subunit-containing NMDA receptors in the adult hippocampus. Moreover, NMDA receptor subunits are heterogeneously distributed along the apical dendrites of CA1 pyramidal neurons, such that GluN2B-lacking NMDA receptors selectively concentrate …
-
Super-resolution imaging of glutamate receptors in cultured hippocampal neurons under basal and LTP conditions
… population of the two NMDAR subunits (GluN2A and GluN2B) are found to be very different. This ratio is known to be significant in neuronal function/dysfunction. We also quantified this ratio during the maturation process and find redistribution of the synaptic/extrasynaptic NMDARs. …
-
Synapse Dysfunction Induced by Autism Spectrum Disorder Associated Shank3 Mutations
… down-regulation, indicating a possible change to GluN2A-containing NMDARs. This may in part contribute to the deficit in NMDARdependent LTP observed in neurons with loss of Shank3 by altering the threshold for LTP induction. In contrast, we found that both the NMDAR and the mGluR-dependent forms …
-
Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression
… of α5- and β3-GABAAR </p> <p>subunits, and the GluN2A subunit in the hippocampus. Seven days of zolpidem resulted in a decrease in total α2 subunit protein level and 7 days of diazepam decreased total γ2 subunit protein levels. Thirty days of diazepam but not zolpidem resulted in cross-tolerance …