Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"GluA1"”.
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Morfiinin vaikutukset ehdollistetussa paikkahakuisuuskokeessa AMPA-tyypin glutamaattireseptorin GluA1-alayksikön poistogeenisillä hiirillä
… Glutamatergic AMPA receptor and especially its GluA1 subunit are thought to be included in the neurobiological mechanisms related to drug addiction. Compulsive drug craving and relapses to drug use after a period of abstinence are central problems among people suffering drug addiction. …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… of Nedd4-2, including the major subunit (GluA1) of an ionotropic glutamate receptor, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, which our lab has identified. AMPA receptors (AMPARs) are the most commonly found receptors in the mammalian nervous system, …
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Super-resolution imaging of glutamate receptors in cultured hippocampal neurons under basal and LTP conditions
… membrane. In particular, the AMPAR subunits GluA1 and GluA2 are known to contribute to cLTP, but a quantitative understanding is missing in terms of the AMPAR insertion sites on the postsynaptic membrane; how AMPARs move after insertion; and if there are structural changes of AMPARs upon …
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AMPA receptor diversity and dynamics during excitatory synaptic transmission
… AMPAR tetramer by the choice of core subunit (GluA1-4), as well as their association with various auxiliary subunits. Using results from a combination of electrophysiology and light microscopy, this thesis probes the synaptic trafficking and short-term and long-term plasticity behaviour of …
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Structural and Functional Effect of Phosphorylation On Ampa Receptors
… S831, and T840 in the C-terminal segment of GluA1 homomeric AMPA receptor are phosphorylated by PKC, and phosphorylation at these sites leads to an increase in receptor conductance. We show that the domain inclusive of those sites alters its secondary structure due to phosphorylation (using …
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Investigating the Molecular Function of APP Interacting Proteins in Synaptic Neuromodulation
… data indicated that CNTN4 interacts with the GluA1 and GluA2 subunits of AMPARs primarily via its extracellular fibronectin type III (FNIII) domain. Notably, this interaction occurs independently of APP. Acute knockdown of Cntn4 resulted in a reduction of both surface and total GluA1/2 levels, …
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Insulin Modulates Synaptic Transmission and AMPA Receptor Trafficking Via Insulin Receptor Signaling Molecule In Region CA1 of the Juvenile and Mature Hippocampuss
… in the surface expression of the GluA2 and GluA1 subunits; and that insulin caused a decrease in phosphorylation of the GluA1 subunit on the S845 residue. In both juvenile and mature animals, inhibition of N-methyl-D-aspartate receptors (NMDARs) or phosphatidylinositol 3-kinase (PI3K) did …
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Withdrawal from Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities to Behavioral Deficits and Neurochemical Perpetuators of Neurotoxicity and Drug Seeking Behavior
… abstinence to assess <em>1. sex differences in GluA1, GluA2, and GSK3</em><em>β signaling in mice that consume variable amounts of MA to investigate differential susceptibility to persistent synaptic plasticity deficits and drug seeking behavior following withdrawal from MA 2. sex differences in …
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Characterisation of leptin mimetic agents as therapeutic targets in Alzheimer's disease
… also mirrored leptin (116-130) effects on GluA1 surface expression. In contrast, the last four hexamer fragments (121-126; 123-128; 124-129; 125-130) showed no effects on hippocampal LTP or GluA1 surface expression.<br/><br/>Finally, the active site of the leptin molecule lies between amino …
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Targeting AMPA Receptor Modulation during Early Life Adversity: A Mediator for Threat Associated Memories
… hippocampus and amygdala were evaluated for GluA1-3, PKMz and PSD95.</p> <p>We found that:</p> <p>(1) As expected, both juvenile and adults have intact threat memory retrieval 24 hours post-training. However, at 7 days post-training only adults exhibit a sustained threat memory</p> <p>(2) …
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WWC2 Is a Novel Regulator of GABAAR Expression, Synaptic Function, and Dendritic Morphology in Excitatory Hippocampal Neurons
… have unchanged expression of AMPAR subunits GluA1 and GluA2. I further make use of conditional knockout models to show that WWC2 loss leads to dysregulated baseline synaptic function and decreased dendritic branching in hippocampal neurons. Preliminary studies indicate that CA1 pyramidal …
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Ampa Receptor Dysregulation And Therapeutic Interventions In A Mouse Model Of Cdkl5 Deficiency Disorder
… (AMPAR) subunit GluA2 as well as decreased GluA2:GluA1 in the hippocampus of R59X mice, suggesting an increase in hippocampal GluA2-lacking AMPARs, which are calcium permeable and have significant roles in regulating neuronal plasticity and excitability. Indeed, decreased hippocampal GluA2 was …
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GPR30: a role for a novel estrogen-sensing receptor in hippocampal function?
… in a reduction in the relative density of GluA1-containing AMPA receptors expressed at synapses. In addition, further investigation into the pharmacology of the G1-induced LTD revealed that this effect was not prevented by selective antagonists for GPR30, ERa or ERß, however could be …
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Cannabinoid regulation of excitatory synaptic transmission at hippocampal synapses
… and involves PI3K-dependent trafficking of GluA1 to synapses. CBD also exhibits neuroprotective properties as it prevents the detrimental effects of Aβ1-42; a pathological hallmark of Alzheimer’s disease (AD; Shankar et al., 2008), on synaptic plasticity at TA-CA1 synapses.<br/><br/>Taken …
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Synaptic Mechanisms Underlying Treatment of Depression and Bipolar Disorder
… decrease in surface expression of the GluA1 subunit of the AMPAR. Collectively, this data demonstrates that BDNF is required for the antimanic effects of lithium, and that lithium's effects on the regulation of AMPARs are BDNF and TrkB dependent, which may underlie its behavioral effect.