Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Glomerulosclerosis"”.
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Modelling Human Glomerulosclerosis in vitro
Glomerulosclerosis is a feature of many chronic kidney diseases. Glomeruli are composed of glomerular endothelial cells (GECs), podocytes (PODs) and mesangial cells (MCs), and dysregulation in the interaction between these cell types results in glomerulosclerosis. This is characterised by excessive …
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alpha-Actinin-4 and the podocyte: Implications for focal segmental glomerulosclerosis
Focal and segmental glomerulosclerosis (FSGS) is a common glomerular lesion and a significant cause of end-stage renal disease (ESRD). FSGS lesions result from damage to glomerular epithelial cells called podocytes, a key cell type involved in glomerular filtration. Mutations in the ACTN4 gene, …
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Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
The Col1a2-deficient (oim) mouse model exclusively synthesizes homotrimeric type I collagen due to the lack of functional pro [alpha] 2(I) collagen chains. The mouse develops a type I collagen glomerulopathy that has previously been shown to initiate postnatally and progress in a gene …
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Electron microscopic morphometry of podocyte foot process effacement as a tool to distinguish primary from secondary focal segmental glomerulosclerosis (FSGS)
Background: Focal segmental glomerulosclerosis (FSGS) is a histological pattern of glomerular injury and one of the most common causes of end-stage renal disease in adult patients. Two major subtypes of FSGS (primary oand secondary) have been identified, with differences in clinical presentation, …
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The Roles of Age, Glomerular Location, and Collagen Expression in the Canine Kidney: Analysis of a Lifespan Study
… study was to assess the temporal evolution of glomerulosclerosis, an important renal lesion, in laboratory housed dogs, an important model system in chronic toxicological studies. We histopathologically examined representative sections of dog kidneys, quantified glomerular lesions (using the …
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Transforming growth factor beta 1 : Role in the progression of chronic renal failure.
… in the pathogenesis of experimental and clinical glomerulosclerosis and tubufointerstitial fibrosis. Associations have been described between polymorphisms of cytokine and growth factor genes and susceptibility to, or progression of, an increasing number of diseases. In this study, single …
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Modulation of TGFβ-Induced PAI -1 Expression by Changes in Actin Polymerization in Human Mesangial Cells
… of extracellular matrix (ECM) in the glomerulus (glomerulosclerosis). Glomerulosclerosis is associated with activation of normally quiescent glomerular mesangial cells into myofibroblast-like cells. The overall objective of this study is to delineate cellular mechanism/s of …
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Studying glomerular disease epidemiology: tackling challenges and paving a path forward
… century of the rapid increase in focal segmental glomerulosclerosis observed at the end of the 20th century, and a dramatic increase in diabetic glomerulosclerosis over time, to become the second most frequent biopsy-proven glomerular disease diagnosis in the modern era; c) significant differences …
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Ruolo delle cellule staminali mesenchimali in modelli cellulari e animali di nefropatia
… lipids) but protected the kidney from severe glomerulosclerosis when given concomitantly to ADR. Rats given MSC 60 days after ADR developed the same severe renal damage. Only few MSC were found in renal tubule-interstitial areas after 1-24 hours from injection and no MSC was detected in …
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Engineering Complex Kidney Structures for Disease Modelling, Drug Testing, and Studying Kidney Development
… <i>PAX2</i> mutation affected by focal segmental glomerulosclerosis, we speculated that such developmental disorder might have contributed to the patient’s condition. <br></br><br></br> Overall, these findings document that our innovative and robust technology for controlled tubule engineering …
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Exploring the impact of maternal obesity on offspring renal morphology and later life health
… exposed to maternal obesity had increased glomerulosclerosis and tubulointerstitial fibrosis. The obesity epidemic is attributed to a shift in behaviours towards consumption of energy dense foods and inactivity. In addition, evidence from human and animal studies has highlighted that …
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Clinical Presentation and Histopathological Description of the Spectrum of Renal Diseases in HIV Infected Adults Presenting With Renal Insufficiency at the University Teaching Hospital,Lusaka Zambia
… disease (HIVICK) (32%) and focal segmental glomerulosclerosis (FSGS) (29%) of various histologic variants other than the collapsing type. We did not see the classic HIVAN on histopathology in our study population. All the patients presented with severe renal dysfunction with mean eGFR of 17 …
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Clinical Presentation and Histopathological Description of the Spectrum of Renal Diseases in HIV Infected Adults Presenting With Renal Insufficiency at the University Teaching Hospital,Lusaka Zambia
… disease (HIVICK) (32%) and focal segmental glomerulosclerosis (FSGS) (29%) of various histologic variants other than the collapsing type. We did not see the classic HIVAN on histopathology in our study population. All the patients presented with severe renal dysfunction with mean eGFR of 17 …
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Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn)
… included renal and glomerular hypertrophy, glomerulosclerosis and tubulo-interstitial changes. In conclusion, transgenic mice expressing a dominant negative GIP receptor under the control of the rat insulin gene promoter develop a severe diabetic phenotype and striking 138 histological …
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Proliferationsverhalten kultivierter Mesangialzellen und glatter Gefäßmuskelzellen nach Stimulation mit Angiotensin II und atherogenen Lipoproteinen : Rezeptorbeteiligung
Hintergrund: Atherogene Lipoproteine und Angiotensin II sind an der Entstehung von Athe-rosklerose und Glomerulosklerose maßgeblich beteiligt. Sowohl klinische Studien als auch experimentelle Beobachtungen weisen auf eine Interaktion beider Substanzen im Sinne ei-ner Potenzierung ihrer …
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Ca²⁺ and phosphoinositides regulations in α-actinin -4 F-actin binding.
… cell lung cancer (SCLC) and focal segmental glomerulosclerosis (FSGS). The mutation site within these mutants is located on the actin binding region. Therefore, the actin binding region is presumed to be associated with the progression of human disease. The aims of this thesis focused on the …