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Showing 1 to 20 of 54 for “"Glomerulonephritis"”.
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A glomerulonephritis associated with acute Babesia rodhaini infections of rats
Thesis (M.S.)--Michigan State University. Dept. of Biological Services, 1968
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Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
… of anti-glomerular basement membrane (anti-GBM) glomerulonephritis and Systemic Lupus Erythematosus (SLE). SV40-transformed mouse mesangial cells (MES13) were cultured with pure CLA isomers (c9,t11 or t10,c12-CLA or a 50:50 mixture prior to immune stimulation with lipopolysaccharide and …
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Clinico-pathological correlation and outcome in patients with mesangioproliferative glomerulonephritis in Cape Town: A single centre study
Background Glomerulonephritis is a major cause of end-stage kidney disease (ESRD) in Africa. There is scanty data on the clinico-pathological characteristics and outcome of the mesangioproliferative glomerulonephritides in Africa, despite the non-IgA subtype being reported as a common cause of …
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A ten year retrospective study of the aetiology and outcome of crescentic glomerulonephritis in children presenting to the Red Cross Children's Hospital, Cape Town, South Africa
Background: Crescentic glomerulonephritis represents the extreme end on the spectrum of glomerular injury. It can result from a wide range of disease conditions and clinically is marked by a rapid deterioration in renal function over days, weeks or months. Although rare, crescentic …
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Differentielle Genexpression bei der Membranösen Glomerulonephritis und die Rolle des 'bone morphogenetic protein 2' für die Funktion des Podozyten
Die membranöse Glomerulonephritis (mGN) ist eine Immunkomplexnephritis, bei der es zu einer Schädigung des Podozyten mit nachfolgender Proteinurie kommt. Unklar ist, welche zellulären Mechanismen zu der anhaltenden Funktionsstörung des Podozyten führen. Die Ergebnisse der vorliegenden Arbeit lassen …
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Epidemiology and clinical outcomes of patients with idiopathic membranous glomerulonephritis at Groote Schuur Hospital over a ten year period
BACKGROUND: Glomerulonephritis is a common cause of end-stage renal disease (ESRD) in developing countries. Idiopathic membranous nephropathy (IMGN) is an identified cause of nephrotic syndrome in South Africa. Early attainment of complete remission (CR) or partial remission (PR) in patients with …
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Acute post streptococcal glomerulonephritis at Red Cross War Memorial Children's Hospital, Cape Town, South Africa - a five-and half-year descriptive review
Background: Acute post streptococcal glomerulonephritis (APSGN), although not a common cause of progressive kidney failure, is an important cause of paediatric hospital admission, parental worry, and acute kidney injury (AKI). In well-resourced settings, there has been a decline over the last three …
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Characterizing the roles of gut microbiota, probiotic Lactobacilli and CX3CR1 in the development of autoimmunity in MRL/lpr mice
… drift, most significantly the attenuation of glomerulonephritis, was present in both colonies. In addition, while JAX mice and mice in our colony are genetically identical, there were minor differences in disease that might be due to differences in splenic microRNAs and the gut microbiota. …
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Factors affecting severity of injury in allergic renal disease
… pathogenetic mechanisms involved in human glomerulonephritis. The first part of this thesis reviews the literature with regard to the factors and mechanisms responsible for the causation of glomerulonephritis and those factors which determine severity and allow for its persistence. In order …
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Urinary Biomarkers and Patient Outcome in Chronic Kidney Disease and Atherosclerotic Heart Disease: The value of IgM-uria and IgG-uria
… kidney and CV outcome in patients with diabetes, glomerulonephritis and atherosclerotic heart disease. In study I, 139 patients with type-1 diabetes, and in study II, 106 patients with type-2 diabetes, were followed at the diabetes outpatient clinic, for an average of 18 and 5 years, respectively. …
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A comparison of clinical, biochemical, and histological characteristics as well as evaluation of outcomes of patient with mesangiovapillary glomerulonephritis (MCGN) in HIV positive and negative patients at a tertiary hospital in Cape Town, South Africa
Background & Aim Mesangiocapillary glomerulonephritis (MCGN) is a common histological pattern of glomerular injury in developing countries. South Africa has the highest proportion of people living with HIV (PWH) and the co-existence of MCGN and HIV may affect kidney prognosis. The aim of this study …
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Studies on anti-dsDNA Antibodies and other potential biomarkers in Systemic Lupus Erythematosus
… the assay used, is significantly associated with glomerulonephritis and pleuritis, regardless of the diagnosis. The positivity confirmed by two different methods tends also to cluster with hematological manifestations. We suggest that anti-dsDNA antibodies should be used as biomarkers of certain …
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The Role of Von Hippel-Lindau Protein in the Glomerulus
Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome characterized by loss of renal function within days to weeks and by glomerular crescents on biopsy. The pathogenesis of this disease is unclear, but circulating factors such as antineutrophil cytoplasmic antibodies (ANCA) are …
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Genetic and Acquired Abnormalities in C3 Glomerulopathy and Primary Immune Complex-Mediated MPGN
Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of glomerular injury that mainly occurs in children and young adults. <br></br><br></br> MPGN is currently classified in immune complex-mediated MPGN (IC-MPGN), characterized by activation of the complement classic pathway, and C3 …
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Investigations into the role of exogenous estrogenic endocrine disrupting chemicals on immune dysregulation in autoimmune disease
… phytoestrogens developed significantly reduced glomerulonephritis and glomerular immune complex deposition compared to mice fed a diet containing soy isoflavones. Diet also influenced cytokine production and epigenetics of LPS-stimulated splenic leukocytes. We identified similar effects of E2 …
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